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Master athletes have higher miR-7, SIRT3 and SOD2 expression in skeletal muscle than age-matched sedentary controls

Koltai, Erika and Bori, Zoltan and Osvath, Peter and Ihasz, Ferenc and Peter, Szablics and Toth, Geza and Degens, Hans and Rittweger, Jörn and Boldogh, Istvan and Radak, Zsolt (2018) Master athletes have higher miR-7, SIRT3 and SOD2 expression in skeletal muscle than age-matched sedentary controls. Redox Biology (19), pp. 46-51. Elsevier. DOI: 10.1016/j.redox.2018.07.022 ISSN 2213-2317

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Official URL: https://www.sciencedirect.com/science/article/pii/S2213231718302751#!

Abstract

Regular physical exercise has health benefits and can prevent some of the ageing-associated muscle deteriorations. However, the biochemical mechanisms underlying this exercise benefit, especially in human tissues, are not well known. To investigate, we assessed this using miRNA profiling, mRNA and protein levels of anti-oxidant and metabolic proteins in the vastus lateralis muscle of master athletes aged over 65 years and age-matched controls. Master athletes had lower levels of miR-7, while mRNA or protein levels of SIRT3, SIRT1, SOD2, and FOXO1 levels were significantly higher in the vastus lateralis muscle of master athletes compared to muscles of age-matched controls. These results suggest that regular exercise results in better cellular metabolism and antioxidant capacity via maintaining physiological state of mitochondria and efficient ATP production and decreasing ageing-related inflammation as indicated by the lower level of miR-7 in master athletes.

Item URL in elib:https://elib.dlr.de/124598/
Document Type:Article
Title:Master athletes have higher miR-7, SIRT3 and SOD2 expression in skeletal muscle than age-matched sedentary controls
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Koltai, ErikaResearch Institute of Sport Science, University of Physical Education, Budapest, HungaryUNSPECIFIED
Bori, ZoltanResearch Institute of Sport Science, University of Physical Education, Budapest, HungaryUNSPECIFIED
Osvath, PeterDepartment of Health Sciences and Sports Medicine, University of Physical Education, Budapest, HungaryUNSPECIFIED
Ihasz, FerencHungary Institute of Sport Science, Faculty of Education and Psychology, Eotvos University, Szombathely, HungaryUNSPECIFIED
Peter, SzablicsInstitute of Physical Education and Sport Science, JGYPK, University of Szeged, Szeged, HungaryUNSPECIFIED
Toth, GezaAffidea Diagnostic Center, Budapest, HungaryUNSPECIFIED
Degens, HansManchester Metropolitan UniversityUNSPECIFIED
Rittweger, JörnJoern.Rittweger (at) dlr.dehttps://orcid.org/0000-0002-2223-8963
Boldogh, IstvanUniversity of Texas Medical Branch at Galveston, TXhttps://orcid.org/0000-0002-0088-1130
Radak, ZsoltResearch Institute of Sport Science, University of Physical Education, Budapest, HungaryUNSPECIFIED
Date:October 2018
Journal or Publication Title:Redox Biology
Refereed publication:Yes
Open Access:Yes
Gold Open Access:Yes
In SCOPUS:Yes
In ISI Web of Science:Yes
DOI :10.1016/j.redox.2018.07.022
Page Range:pp. 46-51
Publisher:Elsevier
ISSN:2213-2317
Status:Published
Keywords:Master athlete; miRNA; Skeletal muscle; Anti-oxidant;
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Systemphysiologie
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Muscle and Bone Metabolism
Deposited By: Becker, Christine
Deposited On:11 Dec 2018 11:51
Last Modified:11 Dec 2018 11:51

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