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Sarcolab pilot study into skeletal muscle’s adaptation to long-term spaceflight

Rittweger, Jörn and Albracht, Kirsten and Flück, Martin and Ruoss, Severin and Brocca, Lorenza and Longa, Emanuela and Moriggi, Manuela and Seynnes, Olivier and Di Giulio, Irene and Tenori, Leonardo and Vignoli, Alessia and Capri, Miriam and Gelfi, Cecilia and Luchinat, Claudio and Franceschi, Claudio and Bottinelli, Roberto and Cerretelli, Paolo and Narici, Marco (2018) Sarcolab pilot study into skeletal muscle’s adaptation to long-term spaceflight. npj Microgravity, 4 (18), pp. 1-9. Nature Publishing Group. DOI: 10.1038/s41526-018-0052-1 ISSN 2373-8065

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Official URL: https://www.nature.com/articles/s41526-018-0052-1#article-info

Abstract

Spaceflight causes muscle wasting. The Sarcolab pilot study investigated two astronauts with regards to plantar flexor muscle size, architecture, and function, and to the underlying molecular adaptations in order to further the understanding of muscular responses to spaceflight and exercise countermeasures. Two crew members (A and B) spent 6 months in space. Crew member A trained less vigorously than B. Postflight, A showed substantial decrements in plantar flexor volume, muscle architecture, in strength and in fiber contractility, which was strongly mitigated in B. The difference between these crew members closely reflected FAK-Y397 abundance, a molecular marker of muscle’s loading history. Moreover, crew member A showed downregulation of contractile proteins and enzymes of anaerobic metabolism, as well as of systemic markers of energy and protein metabolism. However, both crew members exhibited decrements in muscular aerobic metabolism and phosphate high energy transfer. We conclude that countermeasures can be effective, particularly when resistive forces are of sufficient magnitude. However, to fully prevent space-related muscular deterioration, intersubject variability must be understood, and intensive exercise countermeasures programs seem mandatory. Finally, proteomic and metabolomic analyses suggest that exercise benefits in space may go beyond mere maintenance of muscle mass, but rather extend to the level of organismic metabolism.

Item URL in elib:https://elib.dlr.de/124592/
Document Type:Article
Title:Sarcolab pilot study into skeletal muscle’s adaptation to long-term spaceflight
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Rittweger, Jörnjoern.rittweger (at) dlr.dehttps://orcid.org/0000-0002-2223-8963
Albracht, KirstenGerman Sport University Colognehttps://orcid.org/0000-0002-4271-2511
Flück, MartinDepartment of Orthopaedics, University of Zürich, Zürich, Switzerlandhttps://orcid.org/0000-0002-0479-7243
Ruoss, SeverinDepartment of Orthopaedics, University of Zürich, Zürich, Switzerlandhttps://orcid.org/0000-0001-8896-635X
Brocca, LorenzaDepartment of Molecular Medicine, University of Pavia, Pavia, Italyhttps://orcid.org/0000-0003-1048-0573
Longa, EmanuelaDepartment of Molecular Medicine, University of Pavia, Pavia, ItalyUNSPECIFIED
Moriggi, ManuelaCNR-IBFM, Segrate, MI, ItalyUNSPECIFIED
Seynnes, OlivierDepartment of Physical Performance, Norwegian School of Sport Sciences, Oslo, NorwayUNSPECIFIED
Di Giulio, IreneCentre for Human and Applied Physiological Sciences, King’s College London, London, UKUNSPECIFIED
Tenori, LeonardoDepartment of Experimental and Clinical Medicine, University of Florence, Florence, ItalyUNSPECIFIED
Vignoli, AlessiaCERM Centro di Ricerca di Risonanze Magnetiche, Florence, ItalyUNSPECIFIED
Capri, MiriamDepartment of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italyhttps://orcid.org/0000-0001-9077-0401
Gelfi, CeciliaUniversity of MilanUNSPECIFIED
Luchinat, ClaudioCERM Centro di Ricerca di Risonanze Magnetiche, Florence, ItalyUNSPECIFIED
Franceschi, ClaudioUniversity of BolognaUNSPECIFIED
Bottinelli, RobertoUniversity of PaviaUNSPECIFIED
Cerretelli, PaoloCNR MilanUNSPECIFIED
Narici, MarcoDepartment of Biomedical Sciences, University of Padova, Padova, ItalyUNSPECIFIED
Date:17 September 2018
Journal or Publication Title:npj Microgravity
Refereed publication:Yes
Open Access:Yes
Gold Open Access:Yes
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:4
DOI :10.1038/s41526-018-0052-1
Page Range:pp. 1-9
Publisher:Nature Publishing Group
ISSN:2373-8065
Status:Published
Keywords:Sarcolab; skeletal muscle; long-term spaceflight; muscle wasting; plantar Flexor;countermeasure;muscle metabolism;
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Systemphysiologie
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Muscle and Bone Metabolism
Deposited By: Becker, Christine
Deposited On:11 Dec 2018 11:50
Last Modified:11 Dec 2018 11:50

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