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Modeling regulation of vascular tone following muscle contraction: Model development, validation and global sensitivity analysis

Keijsers, J.M.T. and Leguy, C.A.D. and Narracott, A.J. and Rittweger, J. and van de Vosse, F.N. and Huberts, W. (2018) Modeling regulation of vascular tone following muscle contraction: Model development, validation and global sensitivity analysis. Journal of Computational Science, 24, pp. 143-159. Elsevier. DOI: 10.1016/j.jocs.2017.04.007 ISSN 1877-7503

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Official URL: https://www.sciencedirect.com/science/article/pii/S1877750317304106

Abstract

In this study the regulation of vascular tone inducing the blood flow increase at the onset of exercise is examined. Therefore, our calf circulation model was extended with a regulation model to simulate changes in vascular tone depending on myogenic, metabolic and baroreflex regulation. The simulated blood flow corresponded to the in vivo response and it was concluded that metabolic activation caused the flow increase shortly after muscle contraction. Secondly, the change in baseline flow upon tilt was a result of myogenic and baroreflex activation. Based on a sensitivity analysis the myogenic gain was identified as most important parameter.

Item URL in elib:https://elib.dlr.de/124589/
Document Type:Article
Title:Modeling regulation of vascular tone following muscle contraction: Model development, validation and global sensitivity analysis
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Keijsers, J.M.T.Institute of Aerospace Medicine, German Aerospace CenterUNSPECIFIED
Leguy, C.A.D.Institute of Aerospace Medicine, German Aerospace CenterUNSPECIFIED
Narracott, A.J.Medical Physics Group, Department of Cardiovascular Science, University of SheffieldUNSPECIFIED
Rittweger, J.Joern.Rittweger (at) dlr.dehttps://orcid.org/0000-0002-2223-8963
van de Vosse, F.N.Department of Biomedical Engineering, Eindhoven University of Technology,UNSPECIFIED
Huberts, W.Department of Biomedical Engineering, Eindhoven University of TechnologyUNSPECIFIED
Date:2018
Journal or Publication Title:Journal of Computational Science
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:24
DOI :10.1016/j.jocs.2017.04.007
Page Range:pp. 143-159
Publisher:Elsevier
ISSN:1877-7503
Status:Published
Keywords:Regulation of vascular tone; Metabolic regulation; Myogenic regulation; Baroreflex; 1D pulse wave propagation
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Systemphysiologie
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Muscle and Bone Metabolism
Deposited By: Becker, Christine
Deposited On:11 Dec 2018 11:46
Last Modified:11 Dec 2018 11:46

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