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Keijsers, J.M.T. and Leguy, C.A.D. and Narracott, A.J. and Rittweger, J. and van de Vosse, F.N. and Huberts, W. (2018) Modeling regulation of vascular tone following muscle contraction: Model development, validation and global sensitivity analysis. Journal of Computational Science, 24, pp. 143-159. Elsevier. doi: 10.1016/j.jocs.2017.04.007. ISSN 1877-7503.
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Official URL: https://www.sciencedirect.com/science/article/pii/S1877750317304106
Abstract
In this study the regulation of vascular tone inducing the blood flow increase at the onset of exercise is examined. Therefore, our calf circulation model was extended with a regulation model to simulate changes in vascular tone depending on myogenic, metabolic and baroreflex regulation. The simulated blood flow corresponded to the in vivo response and it was concluded that metabolic activation caused the flow increase shortly after muscle contraction. Secondly, the change in baseline flow upon tilt was a result of myogenic and baroreflex activation. Based on a sensitivity analysis the myogenic gain was identified as most important parameter.
| Item URL in elib: | https://elib.dlr.de/124589/ | |||||||||||||||||||||
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| Document Type: | Article | |||||||||||||||||||||
| Title: | Modeling regulation of vascular tone following muscle contraction: Model development, validation and global sensitivity analysis | |||||||||||||||||||||
| Authors: |
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| Date: | 2018 | |||||||||||||||||||||
| Journal or Publication Title: | Journal of Computational Science | |||||||||||||||||||||
| Refereed publication: | Yes | |||||||||||||||||||||
| Open Access: | No | |||||||||||||||||||||
| Gold Open Access: | No | |||||||||||||||||||||
| In SCOPUS: | Yes | |||||||||||||||||||||
| In ISI Web of Science: | Yes | |||||||||||||||||||||
| Volume: | 24 | |||||||||||||||||||||
| DOI: | 10.1016/j.jocs.2017.04.007 | |||||||||||||||||||||
| Page Range: | pp. 143-159 | |||||||||||||||||||||
| Publisher: | Elsevier | |||||||||||||||||||||
| ISSN: | 1877-7503 | |||||||||||||||||||||
| Status: | Published | |||||||||||||||||||||
| Keywords: | Regulation of vascular tone; Metabolic regulation; Myogenic regulation; Baroreflex; 1D pulse wave propagation | |||||||||||||||||||||
| HGF - Research field: | Aeronautics, Space and Transport | |||||||||||||||||||||
| HGF - Program: | Space | |||||||||||||||||||||
| HGF - Program Themes: | Research under Space Conditions | |||||||||||||||||||||
| DLR - Research area: | Raumfahrt | |||||||||||||||||||||
| DLR - Program: | R FR - Research under Space Conditions | |||||||||||||||||||||
| DLR - Research theme (Project): | R - Vorhaben Systemphysiologie (old) | |||||||||||||||||||||
| Location: | Köln-Porz | |||||||||||||||||||||
| Institutes and Institutions: | Institute of Aerospace Medicine > Muscle and Bone Metabolism | |||||||||||||||||||||
| Deposited By: | Becker, Christine | |||||||||||||||||||||
| Deposited On: | 11 Dec 2018 11:46 | |||||||||||||||||||||
| Last Modified: | 11 Dec 2018 11:46 |
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