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Informational polymers as unambiguous biomarkers for aqueous-based life

Carr, Christopher E. und Saboda, Kendall und Ruvkun, Gary und Zuber, Maria T. und Wassmann, Marko und Rettberg, Petra und Moeller, Ralf (2018) Informational polymers as unambiguous biomarkers for aqueous-based life. In: EANA 2018 - Abstractbook. EANA 2018, 24-28 September 2018, Berlin, Germany.

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Offizielle URL: http://www.eana-net.eu/index.php?page=Conferences/EANA2018

Kurzfassung

The National Aeronautics and Space Administration (NASA)defines life as a “self-sustaining chemical System capable of Darwinian evolution,”yet a NASA-developed ladder of life detection suggests that measuring such evolution is not feasible within the resource constraints of currently-envisioned life detection missions. If true, such missions cannot strictly verify whether life beyond Earth exists. We propose to resolve this issue in two ways. First, we argue that it is possible to make this measurement. By way of example, we report measurement of evolution in Bacillus subtilis 168 subjected to UV exposure, made solely with a small portable nanopore-based single molecule sequencing device, which is broadly compatible with the constraints of life detection missions, especially for Mars. Detected genetic differences suggest an inherent lifestyle tradeoff between adaptation to oxidative stress and growth rates, consistent with an observed slow-growth phenotype. Second, we argue that we can be confident in detecting life without measuring Darwinian evolution per se. For example, amino acid abundance distributions and lipid carbon chain length distributions have previously been proposed as unambiguous biomarkers. Here we focus on informational polymers, e.g. nucleic acids, which form the basis for heredity that enables evolution in all known life. Indeed, long charged polymers may be universal features of aqueous-based life due to their ability to separate information storage from physicochemical properties. The goal to detect not only DNA and RNA, but related or unrelated polymers, will require further development of nascent technologies to enable a broad-based search for life on Mars, Enceladus, and Europa. Informational polymers, in combination with other“unambiguous” biomarkers,can provide a high confidence in detection of life as we know it or as we don’t know it.

elib-URL des Eintrags:https://elib.dlr.de/124455/
Dokumentart:Konferenzbeitrag (Vortrag)
Titel:Informational polymers as unambiguous biomarkers for aqueous-based life
Autoren:
AutorenInstitution oder E-Mail-AdresseAutoren-ORCID-iDORCID Put Code
Carr, Christopher E.Department of Earth, Atmospheric and Planetary Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA and Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, USANICHT SPEZIFIZIERTNICHT SPEZIFIZIERT
Saboda, KendallDepartment of Earth, Atmospheric and Planetary Sciences, Massachusetts Institute of Technology, Cambridge, MA, USANICHT SPEZIFIZIERTNICHT SPEZIFIZIERT
Ruvkun, GaryDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA, USANICHT SPEZIFIZIERTNICHT SPEZIFIZIERT
Zuber, Maria T.Department of Earth, Atmospheric and Planetary Sciences, Massachusetts Institute of Technology, Cambridge, MA, USANICHT SPEZIFIZIERTNICHT SPEZIFIZIERT
Wassmann, MarkoRadiation Biology Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, GermanyNICHT SPEZIFIZIERTNICHT SPEZIFIZIERT
Rettberg, PetraRadiation Biology Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany; petra.rettberg (at) dlr.dehttps://orcid.org/0000-0003-4439-2395NICHT SPEZIFIZIERT
Moeller, RalfRadiation Biology Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany; ralf.moeller (at) dlr.dehttps://orcid.org/0000-0002-2371-0676NICHT SPEZIFIZIERT
Datum:27 September 2018
Erschienen in:EANA 2018 - Abstractbook
Referierte Publikation:Ja
Open Access:Ja
Gold Open Access:Nein
In SCOPUS:Nein
In ISI Web of Science:Nein
Status:veröffentlicht
Stichwörter:"unambiguous" biomarkers
Veranstaltungstitel:EANA 2018
Veranstaltungsort:Berlin, Germany
Veranstaltungsart:internationale Konferenz
Veranstaltungsdatum:24-28 September 2018
HGF - Forschungsbereich:Luftfahrt, Raumfahrt und Verkehr
HGF - Programm:Raumfahrt
HGF - Programmthema:Forschung unter Weltraumbedingungen
DLR - Schwerpunkt:Raumfahrt
DLR - Forschungsgebiet:R FR - Forschung unter Weltraumbedingungen
DLR - Teilgebiet (Projekt, Vorhaben):R - Vorhaben Strahlenbiologie (alt)
Standort: Köln-Porz
Institute & Einrichtungen:Institut für Luft- und Raumfahrtmedizin > Strahlenbiologie
Hinterlegt von: Kopp, Kerstin
Hinterlegt am:10 Dez 2018 15:52
Letzte Änderung:31 Jul 2019 20:22

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