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Cognitive impairments by alcohol and sleep deprivation indicate trait characteristics and a potential role for adenosine A1 receptors

Elmenhorst, E.-M. and Elmenhorst, D. and Benderoth, S. and Kroll, T. and Bauer, A. and Aeschbach, D. (2018) Cognitive impairments by alcohol and sleep deprivation indicate trait characteristics and a potential role for adenosine A1 receptors. Proceedings of the National Academy of Science (PNAS), 115 (31), pp. 8009-8014. National Academy of Sciences. DOI: 10.1073/pnas.1803770115 ISSN 0027-8424

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Official URL: http://www.pnas.org/cgi/doi/10.1073/pnas.1803770115

Abstract

Trait-like differences in cognitive performance after sleep loss put some individuals more at risk than others, the basis of such disparities remaining largely unknown. Similarly, interindividual differences in impairment in response to alcohol intake have been observed. We tested whether performance impairments due to either acute or chronic sleep loss can be predicted by an individual’s vulnerability to acute alcohol intake. Also, we used positron emission tomography (PET) to test whether acute alcohol infusion results in an up-regulation of cerebral A1 adenosine receptors (A1ARs), similar to the changes previously observed following sleep deprivation. Sustained attention in the psychomotor vigilance task (PVT) was tested in 49 healthy volunteers (26 ± 5 SD years; 15 females) (i) under baseline conditions: (ii) after ethanol intake, and after either (iii) total sleep deprivation (TSD; 35 hours awake; n = 35) or (iv) partial sleep deprivation (PSD; four nights with 5 hours scheduled sleep; n = 14). Ethanol- versus placebo-induced changes in cerebral A1AR availability were measured in 10 healthy male volunteers (31 ± 9 years) with [18F]8-cyclopentyl-3-(3-fluoropropyl)-1-propylxanthine (CPFPX) PET. Highly significant correlations between the performance impairments induced by ethanol and sleep deprivation were found for various PVT parameters, including mean speed (TSD, r = 0.62; PSD, r = 0.84). A1AR availability increased up to 26% in several brain regions with ethanol infusion. Our studies revealed individual trait characteristics for being either vulnerable or resilient to both alcohol and to sleep deprivation. Both interventions induce gradual increases in cerebral A1AR availability, pointing to a potential common molecular response mechanism

Item URL in elib:https://elib.dlr.de/122577/
Document Type:Article
Title:Cognitive impairments by alcohol and sleep deprivation indicate trait characteristics and a potential role for adenosine A1 receptors
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Elmenhorst, E.-M.eva-maria.elmenhorst (at) dlr.deUNSPECIFIED
Elmenhorst, D.UNSPECIFIEDUNSPECIFIED
Benderoth, S.sibylle.benderoth (at) dlr.deUNSPECIFIED
Kroll, T.UNSPECIFIEDUNSPECIFIED
Bauer, A.UNSPECIFIEDUNSPECIFIED
Aeschbach, D.daniel.aeschbach (at) dlr.deUNSPECIFIED
Date:2018
Journal or Publication Title:Proceedings of the National Academy of Science (PNAS)
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:115
DOI :10.1073/pnas.1803770115
Page Range:pp. 8009-8014
Publisher:National Academy of Sciences
ISSN:0027-8424
Status:Published
Keywords:Ethanol, Sleep deprivation, adenosine receptor, trait vulnerabilities, human
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Aeronautics
HGF - Program Themes:air traffic management and operations
DLR - Research area:Aeronautics
DLR - Program:L AO - Air Traffic Management and Operation
DLR - Research theme (Project):L - Human factors and safety in Aeronautics
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Sleep and Human Factors Research
Deposited By: Meckes, Elke
Deposited On:08 Nov 2018 13:24
Last Modified:13 Dec 2018 13:26

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