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Associations between quantitative sleep EEG and subsequent cognitive decline in older women

Djonlagic, I. and Aeschbach, Daniel and Harrison, S.L. and Dean, D. and Yaffe, K. and Ancoli-Israel, S. and Stone, K. and Redline, S. (2018) Associations between quantitative sleep EEG and subsequent cognitive decline in older women. Journal of Sleep Research, e12666. Wiley. DOI: 10.1111/jsr.12666 ISSN 0962-1105

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Official URL: https://onlinelibrary.wiley.com/doi/abs/10.1111/jsr.12666

Abstract

The pathophysiological processes of Alzheimer’s dementia predate its clinical manifestation. Sleep disturbances can accelerate the aging process and are common features of dementia. This study examined whether quantitative sleep electroencephalogram changes predate the clinical development of mild cognitive impairment and/or incident dementia. We collected data from a nested case-control sample of women (mean age 83 years) from the Sleep and Cognition Study, an ancillary study to the longitudinal Study of Osteoporotic Fractures, who were characterized as cognitively normal at the time of a baseline polysomnography study (Study of Osteoporotic Fractures visit 8) based on a Mini-Mental Status Exam (MMSE) score >24. Cases (n = 85) were women who developed new mild cognitive impairment or dementia by objective cognitive testing 5 years after polysomnography. Controls were women with no mild cognitive impairment/dementia (n = 85) at baseline or at follow-up. Differences in electroencephalogram absolute and relative power density were observed between the two groups. Specifically, higher electroencephalogram power values were found in the dementia/mild cognitive impairment group, for the alpha (p = .01) and theta bands (p = .04) in non-rapid eye movement sleep, as well as alpha (p = .04) and sigma (p = .04) bands in rapid eye movement sleep. In contrast, there were no group differences in traditional polysomnography measures of sleep architecture and sleep stage distribution, as well as sleep apnea and periodic limb movement indices. Our results provide evidence for quantitative electroencephalogram changes, which precede the clinical onset of cognitive decline and the diagnosis of dementia in elderly women, and support the application of quantitative sleep electroencephalogram analysis as a promising biomarker for imminent cognitive decline.

Item URL in elib:https://elib.dlr.de/121751/
Document Type:Article
Title:Associations between quantitative sleep EEG and subsequent cognitive decline in older women
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Djonlagic, I.UNSPECIFIEDUNSPECIFIED
Aeschbach, DanielDaniel.Aeschbach (at) dlr.deUNSPECIFIED
Harrison, S.L.UNSPECIFIEDUNSPECIFIED
Dean, D.UNSPECIFIEDUNSPECIFIED
Yaffe, K.UNSPECIFIEDUNSPECIFIED
Ancoli-Israel, S.UNSPECIFIEDUNSPECIFIED
Stone, K.UNSPECIFIEDUNSPECIFIED
Redline, S.UNSPECIFIEDUNSPECIFIED
Date:2018
Journal or Publication Title:Journal of Sleep Research
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In SCOPUS:Yes
In ISI Web of Science:Yes
DOI :10.1111/jsr.12666
Page Range:e12666
Publisher:Wiley
Series Name:Regular Research Paper
ISSN:0962-1105
Status:Published
Keywords:aging, longitudinal analysis, memory
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Aeronautics
HGF - Program Themes:air traffic management and operations
DLR - Research area:Aeronautics
DLR - Program:L AO - Air Traffic Management and Operation
DLR - Research theme (Project):L - Human factors and safety in Aeronautics
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Sleep and Human Factors Research
Deposited By: Meckes, Elke
Deposited On:02 Oct 2018 11:52
Last Modified:06 Sep 2019 15:19

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