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Flow-induced adhesion of shear-activated polymers to a substrate

Hoore, Masoud and Rack, Kathrin and Fedosov, Dmitry A. and Gompper, Gerhard (2018) Flow-induced adhesion of shear-activated polymers to a substrate. Journal of Physics - Condensed Matter, 30 (6), 064001. Institute of Physics (IOP) Publishing. DOI: 10.1088/1361-648X/aaa4d5 ISSN 0953-8984

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Official URL: http://iopscience.iop.org/article/10.1088/1361-648X/aaa4d5

Abstract

Adhesion of polymers and proteins to substrates plays a crucial role in many technological applications and biological processes. A prominent example is the von Willebrand factor (VWF) protein, which is essential in blood clotting as it mediates adhesion of blood platelets to the site of injury at high shear rates. VWF is activated by flow and is able to bind efficiently to damaged vessel walls even under extreme flow-stress conditions; however, its adhesion is reversible when the flow strength is significantly reduced or the flow is ceased. Motivated by the properties and behavior of VWF in flow, we investigate adhesion of shear-activated polymers to a planar wall in flow and whether the adhesion is reversible under flow stasis. The main ingredients of the polymer model are cohesive inter-monomer interactions, a catch bond with the adhesive surface, and the shear activation/deactivation of polymer adhesion correlated with its stretching in flow. The cohesive interactions within the polymer maintain a globular conformation under low shear stresses and allow polymer stretching if a critical shear rate is exceeded, which is directly associated with its activation for adhesion. Our results show that polymer adhesion at high shear rates is significantly stabilized by catch bonds, while at the same time they also permit polymer dissociation from a surface at low or no flow stresses. In addition, the activation/deactivation mechanism for adhesion plays a crucial role in the reversibility of its adhesion. These observations help us better understand the adhesive behavior of VWF in flow and interpret its adhesion malfunctioning in VWF-related diseases.

Item URL in elib:https://elib.dlr.de/121213/
Document Type:Article
Title:Flow-induced adhesion of shear-activated polymers to a substrate
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Hoore, MasoudForschungszentrum Jülichhttps://orcid.org/0000-0003-1442-4739
Rack, KathrinKathrin.Rack (at) dlr.dehttps://orcid.org/0000-0002-5794-5705
Fedosov, Dmitry A.Forschungszentrum Jülichhttps://orcid.org/0000-0001-7469-9844
Gompper, GerhardForschungszentrum Jülichhttps://orcid.org/0000-0002-8904-0986
Date:17 January 2018
Journal or Publication Title:Journal of Physics - Condensed Matter
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:30
DOI :10.1088/1361-648X/aaa4d5
Page Range:064001
Publisher:Institute of Physics (IOP) Publishing
ISSN:0953-8984
Status:Published
Keywords:catch bond, catch-slip bond, shear-enhanced adhesion, reversible adhesion, von Willebrand factor, mesoscopic modeling, smoothed dissipative particle dynamics
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Space Technology
DLR - Research area:Raumfahrt
DLR - Program:R SY - Technik für Raumfahrtsysteme
DLR - Research theme (Project):R - Vorhaben SISTEC
Location: Köln-Porz
Institutes and Institutions:Institut of Simulation and Software Technology
Institut of Simulation and Software Technology > High Performance Computing
Deposited By: Rack, Dr. Kathrin
Deposited On:03 Dec 2018 18:00
Last Modified:06 Sep 2019 15:28

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