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Antimicrobial properties of ternary eutectic aluminum alloys

Hahn, Claudia and Hans, Michael and Hein, Christina and Dennstedt, Anne and Mücklich, Frank and Rettberg, Petra and Hellweg, Christine Elisabeth and Leichert, Lars Ingo and Rensing, Christopher and Moeller, Ralf (2018) Antimicrobial properties of ternary eutectic aluminum alloys. BioMetals. Springer. DOI: 10.1007/s10534-018-0119-1 ISSN 0966-0844

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Official URL: http://dx.doi.org/10.1007/s10534-018-0119-1

Abstract

Several Escherichia coli deletion mutants of the Keio collection were selected for analysis to better understand which genes may play a key role in copper or silver homeostasis. Each of the selected E. coli mutants had a deletion of a single gene predicted to encode proteins for homologous recombination or contained functions directly linked to copper or silver transport or transformation. The survival of these strains on pure copper surfaces, stainless steel, and alloys of aluminum, copper and/or silver was investigated. When exposed to pure copper surfaces, E. coli ΔcueO was the most sensitive, whereas E. coli ΔcopA was the most resistant amongst the different strains tested. However, we observed a different trend in sensitivities in E. coli strains upon exposure to alloys of the system Al–Ag–Cu. While minor antimicrobial effects were detected after exposure of E. coli ΔcopA and E. coli ΔrecA to Al–Ag alloys, no effect was detected after exposure to Al–Cu alloys. The release of copper ions and cell-associated copper ion concentrations were determined for E. coli ΔcopA and the wild-type E. coli after exposure to pure copper surfaces. Altogether, compared to binary alloys, ternary eutectic alloys (Al–Ag–Cu) had the highest antimicrobial effect and thus, warrant further investigation.

Item URL in elib:https://elib.dlr.de/120732/
Document Type:Article
Title:Antimicrobial properties of ternary eutectic aluminum alloys
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Hahn, ClaudiaRadiation Biology Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany.UNSPECIFIED
Hans, MichaelGoodyear Dunlop Tires Operations SA, Colmar Berg, Luxembourg and Functional Materials, Saarland University, Saarbrücken, GermanyUNSPECIFIED
Hein, ChristinaInorganic Solid State Chemistry, Saarland University, Saarbrücken, GermanyUNSPECIFIED
Dennstedt, AnneGerman Aerospace Center (DLR e.V.), Institute of Material Physics in Space, Cologne, GermanyUNSPECIFIED
Mücklich, FrankFunctional Materials, Saarland University, Saarbrücken, GermanyUNSPECIFIED
Rettberg, PetraRadiation Biology Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany; petra.rettberg (at) dlr.dehttps://orcid.org/0000-0003-4439-2395
Hellweg, Christine ElisabethRadiation Biology Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany; Christine.Hellweg (at) dlr.dehttps://orcid.org/0000-0002-2223-3580
Leichert, Lars IngoDepartment of Microbial Biochemistry, Ruhr-University Bochum, Bochum, GermanyUNSPECIFIED
Rensing, ChristopherCollege of Resources and Environment, Fujian Agriculture & Forestry University, Fuzhou, ChinaUNSPECIFIED
Moeller, RalfRadiation Biology Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany; ralf.moeller (at) dlr.dehttps://orcid.org/0000-0002-2371-0676
Date:27 June 2018
Journal or Publication Title:BioMetals
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In SCOPUS:Yes
In ISI Web of Science:Yes
DOI :10.1007/s10534-018-0119-1
Publisher:Springer
ISSN:0966-0844
Status:Published
Keywords:Antimicrobial surfaces, Copper/silver, alloys Aluminum, Contact killing, Escherichia coli, Copper release, CopA
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Strahlenbiologie
Location: Köln-Porz
Institutes and Institutions:Institute of Materials Physics in Space
Institute of Aerospace Medicine > Radiation Biology
Deposited By: Kopp, Kerstin
Deposited On:09 Jul 2018 07:19
Last Modified:09 Jul 2018 07:19

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