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Antimicrobial properties of ternary eutectic aluminum alloys

Hahn, Claudia and Hans, Michael and Hein, Christina and Dennstedt, Anne and Mücklich, Frank and Rettberg, Petra and Hellweg, Christine Elisabeth and Leichert, Lars Ingo and Rensing, Christopher and Moeller, Ralf (2018) Antimicrobial properties of ternary eutectic aluminum alloys. BioMetals, 31 (5), pp. 759-770. Springer. doi: 10.1007/s10534-018-0119-1. ISSN 0966-0844.

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Official URL: http://dx.doi.org/10.1007/s10534-018-0119-1


Several Escherichia coli deletion mutants of the Keio collection were selected for analysis to better understand which genes may play a key role in copper or silver homeostasis. Each of the selected E. coli mutants had a deletion of a single gene predicted to encode proteins for homologous recombination or contained functions directly linked to copper or silver transport or transformation. The survival of these strains on pure copper surfaces, stainless steel, and alloys of aluminum, copper and/or silver was investigated. When exposed to pure copper surfaces, E. coli ΔcueO was the most sensitive, whereas E. coli ΔcopA was the most resistant amongst the different strains tested. However, we observed a different trend in sensitivities in E. coli strains upon exposure to alloys of the system Al–Ag–Cu. While minor antimicrobial effects were detected after exposure of E. coli ΔcopA and E. coli ΔrecA to Al–Ag alloys, no effect was detected after exposure to Al–Cu alloys. The release of copper ions and cell-associated copper ion concentrations were determined for E. coli ΔcopA and the wild-type E. coli after exposure to pure copper surfaces. Altogether, compared to binary alloys, ternary eutectic alloys (Al–Ag–Cu) had the highest antimicrobial effect and thus, warrant further investigation.

Item URL in elib:https://elib.dlr.de/120732/
Document Type:Article
Title:Antimicrobial properties of ternary eutectic aluminum alloys
AuthorsInstitution or Email of AuthorsAuthor's ORCID iDORCID Put Code
Hahn, ClaudiaRadiation Biology Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany.UNSPECIFIEDUNSPECIFIED
Hans, MichaelGoodyear Dunlop Tires Operations SA, Colmar Berg, Luxembourg and Functional Materials, Saarland University, Saarbrücken, GermanyUNSPECIFIEDUNSPECIFIED
Hein, ChristinaInorganic Solid State Chemistry, Saarland University, Saarbrücken, GermanyUNSPECIFIEDUNSPECIFIED
Dennstedt, AnneGerman Aerospace Center (DLR e.V.), Institute of Material Physics in Space, Cologne, GermanyUNSPECIFIEDUNSPECIFIED
Mücklich, FrankFunctional Materials, Saarland University, Saarbrücken, GermanyUNSPECIFIEDUNSPECIFIED
Rettberg, PetraUNSPECIFIEDhttps://orcid.org/0000-0003-4439-2395UNSPECIFIED
Hellweg, Christine ElisabethUNSPECIFIEDhttps://orcid.org/0000-0002-2223-3580UNSPECIFIED
Leichert, Lars IngoDepartment of Microbial Biochemistry, Ruhr-University Bochum, Bochum, GermanyUNSPECIFIEDUNSPECIFIED
Rensing, ChristopherCollege of Resources and Environment, Fujian Agriculture & Forestry University, Fuzhou, ChinaUNSPECIFIEDUNSPECIFIED
Moeller, RalfUNSPECIFIEDhttps://orcid.org/0000-0002-2371-0676UNSPECIFIED
Date:27 June 2018
Journal or Publication Title:BioMetals
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In ISI Web of Science:Yes
Page Range:pp. 759-770
Keywords:Antimicrobial surfaces, Copper/silver, alloys Aluminum, Contact killing, Escherichia coli, Copper release, CopA
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - Vorhaben Strahlenbiologie (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Materials Physics in Space
Institute of Aerospace Medicine > Radiation Biology
Deposited By: Kopp, Kerstin
Deposited On:09 Jul 2018 07:19
Last Modified:02 Nov 2023 10:18

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