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Bystander Effects in the Cellular Radiation Response

Diegeler, Sebastian and Baumstark-Khan, Christa and Jordan, Jens and Hellweg, Christine E. (2018) Bystander Effects in the Cellular Radiation Response. In: FASEB JOURNAL (1824). Experimental Biology 2018, 21.-25. April 2018, SAN DIEGO, CALIFORNIA.

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Abstract

The overall response to tumor radiation therapy results from direct radiation damage and indirect bystander effects (RIBE) mediated by secreted molecules and paracrine transfer of short-lived mediators. RIBE can have both detrimental and protective actions on cancerous as well as healthy tissues. Nuclear Factor κB (NF-κB), which governs immune responses, is a prime candidate for mediating RIBE. NF-κB also modulates DNA repair while promoting cellular survival as part of the DNA damage response. After exposure to ionizing radiation NF-κB is activated in directly targeted and non-targeted bystander cells. We tested the hypothesis that the NF-κB status is relevant for induction of RIBE, using a mouse embryonal fibroblasts (MEF) knock-out variant that is unable to activate NF-κB (NF-κB essential modulator knock-out (NEMO ko)).

Item URL in elib:https://elib.dlr.de/120264/
Document Type:Conference or Workshop Item (Poster)
Title:Bystander Effects in the Cellular Radiation Response
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Diegeler, SebastianRadiation Biology Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany.UNSPECIFIED
Baumstark-Khan, ChristaRadiation Biology Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany.UNSPECIFIED
Jordan, JensInstitute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany.UNSPECIFIED
Hellweg, Christine E.Radiation Biology Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany.https://orcid.org/0000-0002-2223-3580
Date:21 April 2018
Journal or Publication Title:FASEB JOURNAL
Refereed publication:Yes
Open Access:Yes
Gold Open Access:No
In SCOPUS:No
In ISI Web of Science:Yes
Status:Published
Keywords:cellular radiation response, bystander effects (RIBE), Nuclear Factor κB (NF-κB)
Event Title:Experimental Biology 2018
Event Location:SAN DIEGO, CALIFORNIA
Event Type:international Conference
Event Dates:21.-25. April 2018
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Strahlenbiologie
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Radiation Biology
Institute of Aerospace Medicine > Leitungsbereich ME
Deposited By: Kopp, Kerstin
Deposited On:29 Jun 2018 10:16
Last Modified:31 Jul 2019 20:17

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