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Deformation regimes of collagen fibrils in cortical bone revealed by in situ morphology and elastic modulus observations under mechanical loading

Yang, P. and Nie, X.-T. and Zhao, D.-D. and Wang, Z. and Li, R. and Xu, H.-Y. and Rittweger, Jörn and Shang, P. (2018) Deformation regimes of collagen fibrils in cortical bone revealed by in situ morphology and elastic modulus observations under mechanical loading. Journal of the Mechanical Behavior of Biomedical Materials, 79, pp. 115-121. Elsevier. DOI: 10.1016/j.jmbbm.2017.12.015 ISBN 29291465 ISSN 1751-6161

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Abstract

The mechanical properties of the bone play a decisive role in the resistance of the bone to fracture. Clinically, the quantity of the bone in the mineral phase has been considered as the gold-standard indicator for the risk of bone fracture. However, the bone is a complex tissue with a hierarchical-structure consisting of organic matrix, mineral hydroxyapatite, and water. Collagen comprises up to 90% of the organic matrix in the bone, and is vital for its mechanical behavior. To date, the morphological and mechanical responses of collagen fibrils in the bone matrix have been largely overlooked. In the present study, an atomic force microscopy-based imaging and indentation approach is introduced and integrated with a tibia axial loading model. The morphology of mineralized Type I collagen fibrils of the murine cortical tibia is imaged after demineralization, and the in situ elastic modulus of the fibrils is quantified at different loading conditions. Results suggested that the mineralized collagen fibrils are stretched in the early phase of bone deformation, characterized by the elongation of the D-periodic spacing. Reorientation of the collagen fibrils is demonstrated in the subsequent phase of bone deformation. The in situ radial elastic modulus of the collagen fibrils remained constant under the tested loading conditions. These experimental findings provide evidence in support of the unique deformation regimes of bone tissue from the perspective of alterations of mineralized collagen fibrils. This study allows the understanding of the unique mechanical behavior of the bone at the nanoscale, and reveals the mechanisms of relevant diseases that impair the mechanical properties of the bone.

Item URL in elib:https://elib.dlr.de/119056/
Document Type:Article
Title:Deformation regimes of collagen fibrils in cortical bone revealed by in situ morphology and elastic modulus observations under mechanical loading
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Yang, P.Pengfei.Yang (at) dlr.deUNSPECIFIED
Nie, X.-T.UNSPECIFIEDUNSPECIFIED
Zhao, D.-D.UNSPECIFIEDUNSPECIFIED
Wang, Z.UNSPECIFIEDUNSPECIFIED
Li, R.UNSPECIFIEDUNSPECIFIED
Xu, H.-Y.UNSPECIFIEDUNSPECIFIED
Rittweger, JörnJoern.Rittweger (at) dlr.dehttps://orcid.org/0000-0002-2223-8963
Shang, P.Northwestern Polytechnical University,Xi'an, ChinaUNSPECIFIED
Date:2018
Journal or Publication Title:Journal of the Mechanical Behavior of Biomedical Materials
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:79
DOI :10.1016/j.jmbbm.2017.12.015
Page Range:pp. 115-121
Publisher:Elsevier
ISSN:1751-6161
ISBN:29291465
Status:Published
Keywords:Atomic force microscopy; Bone; Collagen fibril; Deformation mechanism; in situ elastic modulus
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Systemphysiologie
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Muscle and Bone Metabolism
Deposited By: Polak, Agnieszka
Deposited On:27 Feb 2018 14:57
Last Modified:20 Jan 2020 13:37

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