Loss of maximal explosive power of lower limbs after two weeks of disuse and incomplete recovery after retraining in older adults

Abstract

Disuse-induced loss ofmuscle power can be detrimental in older individuals, seriously impairing functional capacity. In this study, we examined the changes in maximal explosive power (MEP) of lower limbs induced by a 14-day disuse (bed-rest, BR) and a subsequent 14-day retraining, to assess whether the impact of disuse was greater in older than in young men, and to analyse the causes of such adaptations. Sixteen older adults (Old: 55–65 years) and seven Young (18–30 years) individuals participated in this study. In a subgroup of eight Old subjects, countermeasures based on cognitive training and protein supplementation were applied. MEP was measured with an explosive ergometer, muscle mass was determined by magnetic resonance, motor control was studied byEMG,and singlemuscle fibreswere analysed in vastus lateralis biopsy samples. MEP was ~33% lower in Old than in Young individuals, and remained significantly lower (−19%) when normalized by muscle volume. BR significantly affected MEP in Old (−15%) but not in Young. Retraining tended to increase MEP; however, this intervention was not sufficient to restore pre-BR values in Old. Ankle co-contraction increased after BR in Old only, and remained elevated after retraining (+30%). Significant atrophy occurred in slow fibres in Old, and in fast fibres in Young. After retraining, the recovery ofmuscle fibre thickness was partial. The proposed countermeasureswere not sufficient to affectmuscle mass and power. The greater impact of disuse and smaller retraining-induced recovery observed in Old highlight the importance of designing suitable rehabilitation protocols for older individuals.