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Loss of maximal explosive power of lower limbs after two weeks of disuse and incomplete recovery after retraining in older adults

Floreani, M. and Taboga, P. and Botter, A. and Toniolo, L. and Cancellara, L. and Narici, M.V. and Simunic, B. and Pisot, R. and Biolo, G. and Passaro, A. and Rittweger, Jörn and Reggiani, C. and Lazzer, S. (2018) Loss of maximal explosive power of lower limbs after two weeks of disuse and incomplete recovery after retraining in older adults. The Journal of Physiology, 596 (4), pp. 647-665. Wiley. DOI: 10.1113/JP274772 ISBN 29266264 ISSN 0022-3751

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Abstract

Disuse-induced loss ofmuscle power can be detrimental in older individuals, seriously impairing functional capacity. In this study, we examined the changes in maximal explosive power (MEP) of lower limbs induced by a 14-day disuse (bed-rest, BR) and a subsequent 14-day retraining, to assess whether the impact of disuse was greater in older than in young men, and to analyse the causes of such adaptations. Sixteen older adults (Old: 55–65 years) and seven Young (18–30 years) individuals participated in this study. In a subgroup of eight Old subjects, countermeasures based on cognitive training and protein supplementation were applied. MEP was measured with an explosive ergometer, muscle mass was determined by magnetic resonance, motor control was studied byEMG,and singlemuscle fibreswere analysed in vastus lateralis biopsy samples. MEP was ~33% lower in Old than in Young individuals, and remained significantly lower (−19%) when normalized by muscle volume. BR significantly affected MEP in Old (−15%) but not in Young. Retraining tended to increase MEP; however, this intervention was not sufficient to restore pre-BR values in Old. Ankle co-contraction increased after BR in Old only, and remained elevated after retraining (+30%). Significant atrophy occurred in slow fibres in Old, and in fast fibres in Young. After retraining, the recovery ofmuscle fibre thickness was partial. The proposed countermeasureswere not sufficient to affectmuscle mass and power. The greater impact of disuse and smaller retraining-induced recovery observed in Old highlight the importance of designing suitable rehabilitation protocols for older individuals.

Item URL in elib:https://elib.dlr.de/119055/
Document Type:Article
Title:Loss of maximal explosive power of lower limbs after two weeks of disuse and incomplete recovery after retraining in older adults
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Floreani, M.UNSPECIFIEDUNSPECIFIED
Taboga, P.UNSPECIFIEDUNSPECIFIED
Botter, A.UNSPECIFIEDUNSPECIFIED
Toniolo, L.University of Padua, ItalyUNSPECIFIED
Cancellara, L.UNSPECIFIEDUNSPECIFIED
Narici, M.V.University of Nottingham, Nottingham, UKUNSPECIFIED
Simunic, B.University of PrimorskaUNSPECIFIED
Pisot, R.University of PrimorskaUNSPECIFIED
Biolo, G.UNSPECIFIEDUNSPECIFIED
Passaro, A.AOES B.V.UNSPECIFIED
Rittweger, JörnJoern.Rittweger (at) dlr.dehttps://orcid.org/0000-0002-2223-8963
Reggiani, C.University of Padua, ItalyUNSPECIFIED
Lazzer, S.University of Udine, ItalyUNSPECIFIED
Date:2018
Journal or Publication Title:The Journal of Physiology
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:596
DOI :10.1113/JP274772
Page Range:pp. 647-665
Publisher:Wiley
ISSN:0022-3751
ISBN:29266264
Status:Published
Keywords:lower limbs; recovery; older adults; muscle power
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Systemphysiologie
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Muscle and Bone Metabolism
Deposited By: Polak, Agnieszka
Deposited On:14 Mar 2018 11:02
Last Modified:06 Sep 2019 15:30

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