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Branched-chain amino acid catabolism rather than amino acids Plasma concentrations predict diet-induced changes in Insulin resistance

Haufe, S. and Engeli, S. and Kaminski, J. and Witt, H. and Utz, W. and Fuhrmann, J.C. and Rein, D. and Kamlage, B. and Haas, V. and Mähler, A. and Luft, C. and Schulz-Menger, J. and Boschmann, M. and Jordan, J. (2017) Branched-chain amino acid catabolism rather than amino acids Plasma concentrations predict diet-induced changes in Insulin resistance. Nutrition, Metabolism and Cardiovascular Diseases (27), pp. 858-864. Els. ISBN 10.1016/j.numecd.2017.07.001 ISSN 0939-4753

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Official URL: http://www.elsevier.com/locate/nmcd

Abstract

Abstract Background & aims: 3-Hydroxyisobutyrate (3-HIB), a catabolic intermediate of the BCAA valine, which stimulates muscle fatty acid uptake, has been implicated in the pathogen- esis of insulin resistance. We tested the hypothesis that circulating 3-HIB herald insulin resis- tance and that metabolic improvement with weight loss are related to changes in BCAAs and 3- HIB. Methods and results: We analyzed plasma and urine in 109 overweight to obese individuals before and after six months on hypocaloric diets reduced in either carbohydrates or fat. We calculated the homeostasis model assessment index (HOMA-IR) and whole body insulin sensi- tivity from oral glucose tolerance tests and measured intramyocellular fat by magnetic reso- nance spectroscopy. BCAAs and 3-HIB plasma concentrations were inversely related to insulin sensitivity but not to intramyocellular fat content at baseline. With 7.4 ± 4.5% weight loss mean BCAA and 3-HIB plasma concentrations did not change, irrespective of dietary macronutrient content. Individual changes in 3-HIB with 6-month diet but not BCAAs were correlated to the change in whole body insulin sensitivity and HOMA-IR independently of BMI changes. Conclusions: 3-HIB relates to insulin sensitivity but is not associated with intramyocellular fat content in overweight to obese individuals. Moreover, changes in 3-HIB rather than changes in BCAAs are associated with metabolic improvements with weight loss. Registration number for clinical trials: ClinicalTrials.gov Identifier: NCT00956566. ª 2017 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.

Item URL in elib:https://elib.dlr.de/118820/
Document Type:Article
Title:Branched-chain amino acid catabolism rather than amino acids Plasma concentrations predict diet-induced changes in Insulin resistance
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Haufe, S.Hannover Medical School, Hannover, GermanyUNSPECIFIED
Engeli, S.Hannover Medical School, Hannover, GermanyUNSPECIFIED
Kaminski, J.Charité University Medical School and Max Delbrück Cneter for Molecular Medicine, Berlin, GermanyUNSPECIFIED
Witt, H.Metanomics GmbH, Berlin, GermanyUNSPECIFIED
Utz, W.HELIOS Klinikum, Berlin-Buch, GermanyUNSPECIFIED
Fuhrmann, J.C.Metanomics GmbH, Berlin, GermanyUNSPECIFIED
Rein, D.Netanomics Health GmbH, Berlin, GermanyUNSPECIFIED
Kamlage, B.Metanomics Health GmbH, Berlin, GermanyUNSPECIFIED
Haas, V.Chartié University Medical School and Max Delbrück Center for Molecular Medicine, Berlin, GermanyUNSPECIFIED
Mähler, A.Charité University Medical School and Max Delbrück Center for Molecular Medicine, Berlin, GermanyUNSPECIFIED
Luft, C.Charité University Medical SAchool and Max Delbrück Center for Moleclular Medicine, Berlin, GermanyUNSPECIFIED
Schulz-Menger, J.HELIOS Klinikum, Berlin-Buch, GermanyUNSPECIFIED
Boschmann, M.Charité University Medical School and Max Delbrück Center for Molecular Medicine, Berlin, GermanyUNSPECIFIED
Jordan, J.Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany.UNSPECIFIED
Date:11 August 2017
Journal or Publication Title:Nutrition, Metabolism and Cardiovascular Diseases
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In SCOPUS:Yes
In ISI Web of Science:Yes
Page Range:pp. 858-864
Publisher:Els
ISSN:0939-4753
ISBN:10.1016/j.numecd.2017.07.001
Status:Published
Keywords:Insulin sensitivity, Intramyocellular fat, Weight loss
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Systemphysiologie
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Leitungsbereich ME
Deposited By: Jackman, Sabine
Deposited On:07 Feb 2018 14:04
Last Modified:07 Feb 2018 14:04

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