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The effect of empagliflozin on muscle sympathetic nerve activity in patients with type 2 Diabetes mellitus

Jordan, J. and Tank, J. and Heusser, K. and Heise, T. and Wanner, C. and Heer, M. and Macha, S. and Mattheus, M. and Lund, S.S. and Woerle, H.J. and Broedl, U.C. (2017) The effect of empagliflozin on muscle sympathetic nerve activity in patients with type 2 Diabetes mellitus. Journal of the American Society of Hypertension, 11 (9), pp. 604-612. DOI: 10.1016/j.jash.2017.07.005 ISSN 1933-1711

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Abstract

Inhibition of sodium glucose cotransporter 2 with empagliflozin results in caloric loss by increasing urinary glucose excretion and has a mild diuretic effect. Diuretic effects are usually associated with reflex-mediated increases in sympathetic tone, whereas caloric loss is associated with decreased sympathetic tone. In an open-label trial, muscle sympathetic nerve activity (MSNA) (burst frequency, burst incidence, and total MSNA) was assessed using microneurography performed off-treatment and on day 4 of treatment with empagliflozin 25 mg once daily in 22 metformin-treated patients with type II diabetes (mean [range] age 54 [40–65] years). Systolic and diastolic blood pressure (BP), heart rate, urine volume, and body weight were assessed before and on day 4 (BP, heart rate), day 5 (urine volume), or day 6 (body weight) of treatment with empagliflozin. After 4 days of treatment with empagliflozin, no significant changes in MSNA were apparent despite a numerical increase in urine volume, numerical reductions in BP, and significant weight loss. There were no clinically relevant changes in heart rate.

Item URL in elib:https://elib.dlr.de/118817/
Document Type:Article
Title:The effect of empagliflozin on muscle sympathetic nerve activity in patients with type 2 Diabetes mellitus
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Jordan, J.Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany.UNSPECIFIED
Tank, J.Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany.UNSPECIFIED
Heusser, K.Hannover Medical School, Hannover, GermanyUNSPECIFIED
Heise, T.Profil, Neuss, GermanyUNSPECIFIED
Wanner, C.University of Würzburg, Würzburg, GermanyUNSPECIFIED
Heer, M.Profil, Neuss, GermanyUNSPECIFIED
Macha, S.Boehringer Ingelheim Pharmaceuticals, Ridgefield, CT, USAUNSPECIFIED
Mattheus, M.Boehringer Ingelheim Pharma Gmbh & Co. KG, Ingelheim, GermanyUNSPECIFIED
Lund, S.S.Boehringer Ingelheim Pharma GmbH & Co. KG, Ingelheim, GermanyUNSPECIFIED
Woerle, H.J.Boehringer Ingelheim GmbH & Co. KG, Ingelheim, GermanyUNSPECIFIED
Broedl, U.C.Boehringer Ingelheim GmbH & Co. KG, Ingelheim, GermanyUNSPECIFIED
Date:2017
Journal or Publication Title:Journal of the American Society of Hypertension
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:11
DOI :10.1016/j.jash.2017.07.005
Page Range:pp. 604-612
ISSN:1933-1711
Status:Published
Keywords:Blood pressure, Body weight, heart rate, sodium Glucose cotransporter 2 Inhibition, urine volume
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Projekt :envihab
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Leitungsbereich ME
Institute of Aerospace Medicine > Cardiovascular Medicine in Aerospace
Deposited By: Jackman, Sabine
Deposited On:07 Feb 2018 09:58
Last Modified:21 Feb 2018 12:07

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