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PlanHab study: assessment of psycho-neuroendocrine function in male subjects during 21 d of normobaric hypoxia and bed rest

Strewe, C. and Zeller, R. and Feuerecker, M. and Hoerl, M. and Kumprej, I. and Crispin, A. and Johannes, Bernd W. and Debevec, T. and Mekjavic, I. and Schelling, G. and Choukèr, A. (2017) PlanHab study: assessment of psycho-neuroendocrine function in male subjects during 21 d of normobaric hypoxia and bed rest. Stress: The International Journal on the Biology of Stress, 20 (2), pp. 131-139. Taylor & Francis. DOI: 10.1080/10253890.2017.1292246 ISSN 1025-3890

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Abstract

Immobilization and hypoxemia are conditions often seen in patients suffering from severe heart insufficiency or primary pulmonary diseases (e.g. fibrosis, emphysema). In future planned long-duration and exploration class space missions (including habitats on the moon and Mars), healthy individuals will encounter such a combination of reduced physical activity and oxygen tension by way of technical reasons and the reduced gravitational forces. These overall unconventional extraterrestrial conditions can result in yet unknown consequences for the regulation of stress-permissive, psycho-neuroendocrine responses, which warrant appropriate measures in order to mitigate foreseeable risks. The Planetary Habitat Simulation Study (PlanHab) investigated these two space-related conditions: bed rest as model of reduced gravity and normobaric hypoxia, with the aim of examining their influence on psycho-neuroendocrine responses. We hypothesized that both conditions independently increase measures of psychological stress and enhance neuroendocrine markers of stress, and that these effects would be exacerbated by combined treatment. The cross-over study composed of three interventions (NBR, normobaric normoxic horizontal bed rest; HBR, normobaric hypoxic horizontal bed rest; HAMB, normobaric hypoxic ambulatory confinement) with 14 male subjects during three sequential campaigns separated by 4 months. The psychological state was determined through three questionnaires and principal neuroendocrine responses were evaluated by measuring cortisol in saliva, catecholamine in urine, and endocannabinoids in blood. The results revealed no effects after 3 weeks of normobaric hypoxia on psycho-neuroendocrine responses. Conversely, bed rest induced neuroendocrine alterations that were not influenced by hypoxia.

Item URL in elib:https://elib.dlr.de/118355/
Document Type:Article
Title:PlanHab study: assessment of psycho-neuroendocrine function in male subjects during 21 d of normobaric hypoxia and bed rest
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Strewe, C.Department of Anaesthesiology , Klinikum Großhadern, University of Munich, Stress and Immunology Lab , Munich , GermanyUNSPECIFIED
Zeller, R.Department of Anaesthesiology , Klinikum Großhadern, University of Munich, Stress and Immunology Lab , Munich , GermanyUNSPECIFIED
Feuerecker, M.Department of Anaesthesiology , Klinikum Großhadern, University of Munich, Stress and Immunology Lab , Munich , GermanyUNSPECIFIED
Hoerl, M.Department of Anaesthesiology , Klinikum Großhadern, University of Munich, Stress and Immunology Lab , Munich , GermanyUNSPECIFIED
Kumprej, I.Department of Anaesthesiology , Klinikum Großhadern, University of Munich, Stress and Immunology Lab , Munich , GermanyUNSPECIFIED
Crispin, A.Department of Biometry and Epidemiology, Klinikum Großhadern , University of Munich , Munich , GermanyUNSPECIFIED
Johannes, Bernd W.Bernd.Johannes (at) dlr.deUNSPECIFIED
Debevec, T.Department of Automation, Biocybernetics and Robotics, Jozef Stefan Institute, Ljubljana, SloveniaUNSPECIFIED
Mekjavic, I.Jozef Stefan InstituteUNSPECIFIED
Schelling, G.Department of Anaesthesiology , Klinikum Großhadern, University of Munich, Stress and Immunology Lab , Munich , GermanyUNSPECIFIED
Choukèr, A.Department of Anaesthesiology, Hospital of the University of Munich, Marchioninistrasse 15, München, 81377, Germany.UNSPECIFIED
Date:1 March 2017
Journal or Publication Title:Stress: The International Journal on the Biology of Stress
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:20
DOI :10.1080/10253890.2017.1292246
Page Range:pp. 131-139
Publisher:Taylor & Francis
ISSN:1025-3890
Status:Published
Keywords:Planetary habitat, space flight, bed rest, microgravity, hypoxia, psycho-neuroendocrine response
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Weltraumpsychologie
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Muscle and Bone Metabolism
Deposited By: Becker, Christine
Deposited On:30 Jan 2018 10:05
Last Modified:01 Dec 2018 19:53

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