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The Metabolic Response of Skeletal Muscle to Endurance Exercise Is Modified by the ACE-I/D Gene Polymorphism and Training State

Valdivieso, Paola and Vaughan, David and Laczko, Endre and Brogioli, Michael and Waldron, Sarah and Rittweger, Jörn and Flück, Martin (2017) The Metabolic Response of Skeletal Muscle to Endurance Exercise Is Modified by the ACE-I/D Gene Polymorphism and Training State. Frontiers in Physiology, 8 (993), pp. 1-19. Frontiers Media S.A. DOI: 10.3389/fphys.2017.00993 ISSN 1664-042X

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Official URL: http://frontiersin.org

Abstract

The insertion/deletion polymorphism in the gene for the regulator of vascular tone, angiotensin-converting enzyme (ACE), is the prototype of a genetic influence on physical fitness and this involves an influence on capillary supply lines and dependent Aerobic metabolism in skeletal muscle. The respective interaction of ACE-I/D genotype and training status on local metabolic and angiogenic reactions in exercised muscle is not known. Toward this end we characterized the metabolomic and angiogenic response in knee extensor muscle, m. vastus lateralis, in 18 untrained and 34 endurance-trained (physically active, ˙VO2max > 50mL min−1 kg−1) white British men to an exhaustive bout of one-legged cycling exercise. We hypothesized that training status and ACE-I/D genotype affect supply-related muscle characteristics of exercise performance in correspondence to ACE expression and angiotensin 2 levels. ACE-I/D genotype and training status developed an interaction effect on the cross-sectional area (CSA) of m. vastus lateralis and mean CSA of slow type fibers, which correlated with Peak power output (r ≥ 0.44). Genotype × training interactions in muscle also resolved for exercise-induced alterations of 22 metabolites, 8 lipids, glycogen concentration (p = 0.016), ACE transcript levels (p = 0.037), and by trend for the pro-angiogenic factor tenascin-C post exercise (p = 0.064). Capillary density (p = 0.001), capillary-to-fiber ratio (p = 0.010), systolic blood pressure (p = 0.014), and exercise-induced alterations in the pro-angiogenic protein VEGF (p = 0.043) depended on the ACE-I/D genotype alone. Our observations indicate that variability in aerobic performance in the studied subjects was in part reflected by an ACE-I/D-genotype-modulated metabolic phenotype of a major locomotor muscle. Repeated endurance exercise appeared to override this genetic influence in skeletal muscle by altering the ACE-related metabolic response and molecular aspects of the angiogenic response to endurance exercise.

Item URL in elib:https://elib.dlr.de/118247/
Document Type:Article
Title:The Metabolic Response of Skeletal Muscle to Endurance Exercise Is Modified by the ACE-I/D Gene Polymorphism and Training State
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Valdivieso, PaolaLaboratory for Muscle Plasticity, Department of Orthopedics, Balgrist University Hospital, University of Zurich, SwitzerlandUNSPECIFIED
Vaughan, DavidManchester Metropolitan University, United KingdomUNSPECIFIED
Laczko, EndreFunctional Genomics Center Zurich, ETH, University of Zurich, Zurich, SwitzerlandUNSPECIFIED
Brogioli, MichaelInstitute for Biomedical Research into Human Movement and Health, Manchester Metropolitan UniversityUNSPECIFIED
Waldron, SarahManchester Metropolitan University, United KingdomUNSPECIFIED
Rittweger, JörnJoern.Rittweger (at) dlr.dehttps://orcid.org/0000-0002-2223-8963
Flück, MartinBalgrist University Hospital, University of ZurichUNSPECIFIED
Date:14 December 2017
Journal or Publication Title:Frontiers in Physiology
Refereed publication:Yes
Open Access:Yes
Gold Open Access:Yes
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:8
DOI :10.3389/fphys.2017.00993
Page Range:pp. 1-19
Editors:
EditorsEmail
Milet, Gregoire P.University of Lausanne, Switzerland
Publisher:Frontiers Media S.A
ISSN:1664-042X
Status:Published
Keywords:muscle, exercise, endurance performance, muscle fibers, gene polymorphism, metabolism, metabolome analysis
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):Vorhaben Knocheneigenschaften
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Muscle and Bone Metabolism
Deposited By: Becker, Christine
Deposited On:18 Jan 2018 08:57
Last Modified:10 Jan 2019 15:55

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