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Growth and biofilm formation of Penicillium chrysogenum in simulated microgravity

Cortesao, Marta und Luo, Jiaqi und Müller, Daniel und Nisar, Zeena und Mücklich, Frank und Hemmersbach, Ruth und Hellweg, Christine E. und Zea, Luis und Moeller, Ralf (2017) Growth and biofilm formation of Penicillium chrysogenum in simulated microgravity. 12th conference of the VAAM special group Molecular Biology of Fungi, 28.-30. September 2017, Jena, Germany.

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Kurzfassung

Penicillium sp. are one of the main fungal genera detected on board the Russian Space Station (MIR) and the International Space Station (ISS), demonstrating its ability to grow on the space stations´ walls and to maintain growth under microgravity (1-3). As a spore-forming microorganism, Penicillium sp. poses a concern for planetary protection and to human/astronaut health, as its spores, associated with respiratory diseases, can be dispersed through the air (4). Fungal growth on the ISS has shown to promote biodegradation of the spacecraft materials, compromising their integrity. Biofilms are groups of organisms adhered to each other by self-synthesized extracellular polymeric substances, and are ubiquitous in industrial and natural environments (5). It has been reported that Penicillium sp. forms biofilms, which are associated with higher tolerance/resistance to adverse conditions (6). Therefore, biofilm formed on the ISS may have deleterious effects on astronaut’s health and/or on ISS materials. To gain valuable knowledge to control biofilm during long duration spaceflight missions, the NASA-funded project “Characterization of Biofilm Formation, Growth, and Gene Expression on Different Materials and Environmental Conditions in Microgravity” is currently being prepared. Pre-flight testing include: defining and optimizing the growth medium and culturing conditions of P. chrysogenum DSM 1075; characterizing the morphological response of P. chrysogenum growth under simulated microgravity; assessing biofilm formation by P. chrysogenum under different conditions. The study of this fungal strain represents the beginning of a new line of research on board ISS. The knowledge gained can be applicable to a) the safety and maintenance of crewed spacecraft, b) planetary protection, c) mitigation of biofilm-associated illnesses on the crew, as well as on the Earth. Besides, P. chrysogenum is of major medical and historical importance, as it presents the original and present-day industrial source of the antibiotic penicillin, and as an important producer of antifungal proteins and other relevant enzymes.

elib-URL des Eintrags:https://elib.dlr.de/117269/
Dokumentart:Konferenzbeitrag (Poster)
Titel:Growth and biofilm formation of Penicillium chrysogenum in simulated microgravity
Autoren:
AutorenInstitution oder E-Mail-AdresseAutoren-ORCID-iDORCID Put Code
Cortesao, MartaRadiation Biology Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, GermanyNICHT SPEZIFIZIERTNICHT SPEZIFIZIERT
Luo, JiaqiDepartment of Materials Science and Engineering, Saarland University, Saarbrücken, GermanyNICHT SPEZIFIZIERTNICHT SPEZIFIZIERT
Müller, DanielDepartment of Materials Science and Engineering, Saarland University, Saarbrücken, GermanyNICHT SPEZIFIZIERTNICHT SPEZIFIZIERT
Nisar, ZeenaSpace Technologies, University of Colorado, Boulder, USANICHT SPEZIFIZIERTNICHT SPEZIFIZIERT
Mücklich, FrankDepartment of Materials Science and Engineering, Saarland University, Saarbrücken, GermanyNICHT SPEZIFIZIERTNICHT SPEZIFIZIERT
Hemmersbach, RuthGerman Aerospace Centre (DLR), Institute of Aerospace Medicine, Gravitational Biology, Cologne, Germanyhttps://orcid.org/0000-0001-5308-6715NICHT SPEZIFIZIERT
Hellweg, Christine E.Radiation Biology Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germanyhttps://orcid.org/0000-0002-2223-3580NICHT SPEZIFIZIERT
Zea, LuisSpace Technologies, University of Colorado, Boulder, USANICHT SPEZIFIZIERTNICHT SPEZIFIZIERT
Moeller, RalfRadiation Biology Department, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany; ralf.moeller (at) dlr.dehttps://orcid.org/0000-0002-2371-0676NICHT SPEZIFIZIERT
Datum:2017
Referierte Publikation:Ja
Open Access:Ja
Gold Open Access:Nein
In SCOPUS:Nein
In ISI Web of Science:Nein
Status:veröffentlicht
Stichwörter:microgravity, biofilm, Penicillium sp., growth, ISS, planetary protection, human/astronaut health
Veranstaltungstitel:12th conference of the VAAM special group Molecular Biology of Fungi
Veranstaltungsort:Jena, Germany
Veranstaltungsart:internationale Konferenz
Veranstaltungsdatum:28.-30. September 2017
HGF - Forschungsbereich:Luftfahrt, Raumfahrt und Verkehr
HGF - Programm:Raumfahrt
HGF - Programmthema:Forschung unter Weltraumbedingungen
DLR - Schwerpunkt:Raumfahrt
DLR - Forschungsgebiet:R FR - Forschung unter Weltraumbedingungen
DLR - Teilgebiet (Projekt, Vorhaben):R - Vorhaben Strahlenbiologie (alt), R - Vorhaben Artificial Gravity (alt)
Standort: Köln-Porz
Institute & Einrichtungen:Institut für Luft- und Raumfahrtmedizin > Strahlenbiologie
Institut für Luft- und Raumfahrtmedizin > Gravitationsbiologie
Hinterlegt von: Kopp, Kerstin
Hinterlegt am:11 Jan 2018 13:38
Letzte Änderung:31 Jul 2019 20:14

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