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Margination and stretching of von Willebrand factor in the blood stream enable adhesion

Rack, Kathrin and Huck, Volker and Hoore, Masoud and Fedosov, Dmitry A. and Schneider, Stefan W. and Gompper, Gerhard (2017) Margination and stretching of von Willebrand factor in the blood stream enable adhesion. Scientific Reports, 7, p. 14278. Nature Publishing Group. doi: 10.1038/s41598-017-14346-4. ISSN 2045-2322.

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Official URL: https://www.nature.com/articles/s41598-017-14346-4


The protein von Willebrand factor (VWF) is essential in primary hemostasis, as it mediates platelet adhesion to vessel walls. VWF retains its compact (globule-like) shape in equilibrium due to internal molecular associations, but is able to stretch when a high enough shear stress is applied. Even though the shear-flow sensitivity of VWF conformation is well accepted, the behavior of VWF under realistic blood flow conditions remains poorly understood. We perform mesoscopic numerical simulations together with microfluidic experiments in order to characterize VWF behavior in blood flow for a wide range of flow-rate and hematocrit conditions. In particular, our results demonstrate that the compact shape of VWF is important for its migration (or margination) toward vessel walls and that VWF stretches primarily in a near-wall region in blood flow making its adhesion possible. Our results show that VWF is a highly optimized protein in terms of its size and internal associations which are necessary to achieve its vital function. A better understanding of the relevant mechanisms for VWF behavior in microcirculation provides a further step toward the elucidation of the role of mutations in various VWF-related diseases.

Item URL in elib:https://elib.dlr.de/116629/
Document Type:Article
Title:Margination and stretching of von Willebrand factor in the blood stream enable adhesion
AuthorsInstitution or Email of AuthorsAuthor's ORCID iDORCID Put Code
Rack, KathrinUNSPECIFIEDhttps://orcid.org/0000-0002-5794-5705UNSPECIFIED
Huck, VolkerUniversity Medical Center Hamburg-Eppendorfhttps://orcid.org/0000-0001-8988-1091UNSPECIFIED
Hoore, MasoudForschungszentrum JülichUNSPECIFIEDUNSPECIFIED
Fedosov, Dmitry A.Forschungszentrum Jülichhttps://orcid.org/0000-0001-7469-9844UNSPECIFIED
Schneider, Stefan W.University Medical Center Hamburg-EppendorfUNSPECIFIEDUNSPECIFIED
Gompper, GerhardForschungszentrum Jülichhttps://orcid.org/0000-0002-8904-0986UNSPECIFIED
Date:27 October 2017
Journal or Publication Title:Scientific Reports
Refereed publication:Yes
Open Access:Yes
Gold Open Access:Yes
In ISI Web of Science:Yes
Page Range:p. 14278
Publisher:Nature Publishing Group
Keywords:Biological physics, Computational biophysics, Computational science, Fluid dynamics
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Space System Technology
DLR - Research area:Raumfahrt
DLR - Program:R SY - Space System Technology
DLR - Research theme (Project):R - Vorhaben SISTEC (old)
Location: Köln-Porz
Institutes and Institutions:Institut of Simulation and Software Technology > High Performance Computing
Institut of Simulation and Software Technology
Deposited By: Rack, Dr. Kathrin
Deposited On:12 Jan 2018 11:30
Last Modified:28 Mar 2023 23:50

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