elib
DLR-Header
DLR-Logo -> http://www.dlr.de
DLR Portal Home | Imprint | Privacy Policy | Contact | Deutsch
Fontsize: [-] Text [+]

Increased core body temperature in astronauts during long-duration space missions

Stahn, Alexander C. and Werner, Andreas and Opatz, Oliver and Maggioni, Martina A. and Steinach, Mathias and von Ahlefeld, Victoria Weller and Moore, Alan and Crucian, Brian E. and Smith, Scott M. and Zwart, Sara R. and Schlabs, Thomas and Mendt, Stefan and Trippel, Tobias and Koralewski, Eberhard and Koch, Jochim and Choukèr, Alexander and Reitz, Günther and Shang, Peng and Röcker, Lothar and Kirsch, Karl A. and Gunga, Hanns-Christian (2017) Increased core body temperature in astronauts during long-duration space missions. Scientific Reports, 7 (1). Nature Publishing Group. DOI: 10.1038/s41598-017-15560-w ISSN 2045-2322

[img] PDF
1MB

Official URL: http://dx.doi.org/10.1038/s41598-017-15560-w

Abstract

Humans’ core body temperature (CBT) is strictly controlled within a narrow range. Various studies dealt with the impact of physical activity, clothing, and environmental factors on CBT regulation under terrestrial conditions. However, the effects of weightlessness on human thermoregulation are not well understood. Specifically, studies, investigating the effects of long-duration spaceflight on CBT at rest and during exercise are clearly lacking. We here show that during exercise CBT rises higher and faster in space than on Earth. Moreover, we observed for the first time a sustained increased astronauts’ CBT also under resting conditions. This increase of about 1 °C developed gradually over 2.5 months and was associated with augmented concentrations of interleukin-1 receptor antagonist, a key anti-inflammatory protein. Since even minor increases in CBT can impair physical and cognitive performance, both findings have a considerable impact on astronauts’ health and well-being during future long-term spaceflights. Moreover, our findings also pinpoint crucial physiological challenges for spacefaring civilizations, and raise questions about the assumption of a thermoregulatory set point in humans, and our evolutionary ability to adapt to climate changes on Earth.

Item URL in elib:https://elib.dlr.de/116228/
Document Type:Article
Additional Information:Alexander C. Stahn, Andreas Werner and Hanns-Christian Gunga contributed equally to this work. Correspondence and requests for materials should be addressed to H.-C.G. (email: hanns-christian.gunga@charite.de)
Title:Increased core body temperature in astronauts during long-duration space missions
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Stahn, Alexander C.Charité – Universitätsmedizin Berlinand Berlin Institute of Health, Institute of Physiology, Center for Space Medicine and Extreme Environments, CharitéCrossOver (CCO), Berlin, Germany and Perelman School of Medicine at the University of Pennsylvania, USAUNSPECIFIED
Werner, AndreasGerman Air Force, Centre of Aerospace Medicine, Aviation Physiology Training Centre, Aviation Physiology Diagnostics and Science, Steinborner Str. 43, 01936, Königsbrück, Germany.UNSPECIFIED
Opatz, OliverCharité – Universitätsmedizin Berlinand Berlin Institute of Health, Institute of Physiology, Center for Space Medicine and Extreme Environments, CharitéCrossOver (CCO), Berlin, Germany and Perelman School of Medicine at the University of Pennsylvania, USAUNSPECIFIED
Maggioni, Martina A.Charité – Universitätsmedizin Berlinand Berlin Institute of Health, Institute of Physiology, Center for Space Medicine and Extreme Environments, CharitéCrossOver (CCO), Berlin, Germany and Perelman School of Medicine at the University of Pennsylvania, USAhttps://orcid.org/0000-0002-6319-8566
Steinach, MathiasCharité – Universitätsmedizin Berlinand Berlin Institute of Health, Institute of Physiology, Center for Space Medicine and Extreme Environments, CharitéCrossOver (CCO), Berlin, Germany and Perelman School of Medicine at the University of Pennsylvania, USAUNSPECIFIED
von Ahlefeld, Victoria WellerCharité – Universitätsmedizin Berlinand Berlin Institute of Health, Institute of Physiology, Center for Space Medicine and Extreme Environments, CharitéCrossOver (CCO), Berlin, Germany and Perelman School of Medicine at the University of Pennsylvania, USAUNSPECIFIED
Moore, AlanDepartment of Health and Kinesiology, Lamar University, Beaumont, TX, 77710, USA.UNSPECIFIED
Crucian, Brian E.Biomedical Research and Environmental Sciences Division, NASA Johnson Space Center, Houston, TX, 77058, USA.UNSPECIFIED
Smith, Scott M.Biomedical Research and Environmental Sciences Division, NASA Johnson Space Center, Houston, TX, 77058, USA.UNSPECIFIED
Zwart, Sara R.Preventive Medicine and Community Health, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX, 77555, USA.UNSPECIFIED
Schlabs, ThomasCharité – Universitätsmedizin Berlinand Berlin Institute of Health, Institute of Physiology, Center for Space Medicine and Extreme Environments, CharitéCrossOver (CCO), Berlin, Germany and Perelman School of Medicine at the University of Pennsylvania, USAUNSPECIFIED
Mendt, StefanCharité – Universitätsmedizin Berlinand Berlin Institute of Health, Institute of Physiology, Center for Space Medicine and Extreme Environments, CharitéCrossOver (CCO), Berlin, Germany and Perelman School of Medicine at the University of Pennsylvania, USAhttps://orcid.org/0000-0001-8227-9655
Trippel, TobiasCharité Medizinische Klinik, Charité Universitätsmedizin Berlin, Kardiologie, Augustenburger Platz 1, Berlin, 13353, Germany.UNSPECIFIED
Koralewski, EberhardCharité – Universitätsmedizin Berlinand Berlin Institute of Health, Institute of Physiology, Center for Space Medicine and Extreme Environments, CharitéCrossOver (CCO), Berlin, Germany and Perelman School of Medicine at the University of Pennsylvania, USAUNSPECIFIED
Koch, JochimDrägerwerk AG & Co. KGaA, Moislinger Allee 53-55, Lubeck, 23558, Germany.UNSPECIFIED
Choukèr, AlexanderDepartment of Anaesthesiology, Hospital of the University of Munich, Marchioninistrasse 15, München, 81377, Germany.UNSPECIFIED
Reitz, Güntherradiation biology department, institute of aerospace medicine, german aerospace center (dlr), cologne, germany; guenther.reitz (at) dlr.de and Nuclear Physics Institute of the Czech Academy of Sciences, Praha, Czech Republichttps://orcid.org/0000-0001-5045-0761
Shang, PengKey Laboratory for Space Bioscience & Biotechnology, Institute of Special Environnments Biophysics, School of Life Sciences, Northwestern Polytechnical University, Xi’an, 710072, China.UNSPECIFIED
Röcker, LotharCharité – Universitätsmedizin Berlinand Berlin Institute of Health, Institute of Physiology, Center for Space Medicine and Extreme Environments, CharitéCrossOver (CCO), Berlin, Germany and Perelman School of Medicine at the University of Pennsylvania, USAUNSPECIFIED
Kirsch, Karl A.Charité – Universitätsmedizin Berlinand Berlin Institute of Health, Institute of Physiology, Center for Space Medicine and Extreme Environments, CharitéCrossOver (CCO), Berlin, Germany and Perelman School of Medicine at the University of Pennsylvania, USAUNSPECIFIED
Gunga, Hanns-ChristianCharité – Universitätsmedizin Berlinand Berlin Institute of Health, Institute of Physiology, Center for Space Medicine and Extreme Environments, CharitéCrossOver (CCO), Berlin, Germany and Perelman School of Medicine at the University of Pennsylvania, USAUNSPECIFIED
Date:2017
Journal or Publication Title:Scientific Reports
Refereed publication:Yes
Open Access:Yes
Gold Open Access:Yes
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:7
DOI :10.1038/s41598-017-15560-w
Publisher:Nature Publishing Group
ISSN:2045-2322
Status:Published
Keywords:Humans’ core body temperature (CBT), long-duration space missions
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Strahlenbiologie
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Radiation Biology
Deposited By: Kopp, Kerstin
Deposited On:07 Dec 2017 13:20
Last Modified:08 Mar 2018 18:36

Repository Staff Only: item control page

Browse
Search
Help & Contact
Information
electronic library is running on EPrints 3.3.12
Copyright © 2008-2017 German Aerospace Center (DLR). All rights reserved.