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Shaken not stirred: Comparative studies using 2D-Clinostat and Random Positioning Machine

Brungs, Sonja and Hauslage, Jens and Cevik, Volkan and Hemmersbach, Ruth (2017) Shaken not stirred: Comparative studies using 2D-Clinostat and Random Positioning Machine. 68th International Astronautical Congress, 25. - 29. September 2017, Adelaide, Australien.

Full text not available from this repository.

Official URL: http://www.iafastro.org/events/iac/iac-2017/

Abstract

In the ESA ground-based facility program, clinostats and Random Positioning Machines (RPM) have been applied to simulated microgravity, while centrifuges served as a hypergravity model. First results of cell-based experiments have been recently published. The results clearly demonstrate that device-specific operational modes have to be considered and discussed with respect to the induction of shear forces and in turn their usability as microgravity simulators. In a RPM samples are rotated around two axes with random velocities and directions, while clinostats apply constant rotation around one axis. We will present examples of current investigations visualizing cellular shear forces within a RPM and a clinostat using Dinoflagellates as well as macrophages as cellular reporter systems. The latter has already been studied under real microgravity conditions. We conclude that one axis clinorotation induces substantially less shear forces in comparison to random positioning. Therefore, fast rotating clinostats provide more valid information and should be preferred for the simulation of microgravity in cellular experiments. We believe that this work provides important new insight on the use and limitations of ground-based facilities for the scientific community, which will be crucial in the upcoming post-ISS scenario.

Item URL in elib:https://elib.dlr.de/115025/
Document Type:Conference or Workshop Item (Speech)
Title:Shaken not stirred: Comparative studies using 2D-Clinostat and Random Positioning Machine
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Brungs, Sonjagerman aerospace centre (dlr), institute of aerospace medicine, gravitational biology, cologne, germanyhttps://orcid.org/0000-0002-1277-9942
Hauslage, Jensgerman aerospace centre (dlr), institute of aerospace medicine, gravitational biology, cologne, germanyhttps://orcid.org/0000-0003-2184-7000
Cevik, Volkangerman aerospace centre (dlr), institute of aerospace medicine, gravitational biology, cologne, germanyUNSPECIFIED
Hemmersbach, Ruthgerman aerospace centre (dlr), institute of aerospace medicine, gravitational biology, cologne, germanyhttps://orcid.org/0000-0001-5308-6715
Date:25 September 2017
Refereed publication:No
Open Access:No
Gold Open Access:No
In SCOPUS:No
In ISI Web of Science:No
Status:Published
Keywords:Simulated microgravity, Clinostats, Random Positioning Machines, Hypergravity, Shear forces
Event Title:68th International Astronautical Congress
Event Location:Adelaide, Australien
Event Type:international Conference
Event Dates:25. - 29. September 2017
Organizer:International Astronautical Federation (IAF)
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Biowissenschaftliche Exp.-vorbereitung, R - Vorhaben Biowissenschaftliche Nutzerunterstützung
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Gravitational Biology
Deposited By: Duwe, Helmut
Deposited On:06 Dec 2017 14:22
Last Modified:06 Dec 2017 14:22

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