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T2-relaxation time increases in lumbar intervertebral disks after 21d head-down tilt bed-rest

Koy, Timmo and Ganse, Bergita and Rittweger, Jörn and Pohle-Fröhlich, Regina and Frings-Meuthen, Petra and Johannes, Bernd Wolfgang and Felsenberg, Dieter and Eysel, Peer and Bansmann, Martin and Belavy, Daniel Ludovic (2017) T2-relaxation time increases in lumbar intervertebral disks after 21d head-down tilt bed-rest. Journal of Musculoskeletal and Neuronal Interactions, 17 (3), pp. 140-145. International Society of Musculoskeletal and Neuronal Interactions. ISSN 1108-7161.

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Abstract

Objectives: Spaceflight back pain and intervertebral disc (IVD) herniations cause problems in astronauts. Purpose of this study was to assess changes in T2-relaxation-time through MRI measurements before and after head-down tilt bed-rest, a spaceflight analog. Methods: 8 men participated in the bed-rest study. Subjects remained in 6° head down tilt bed-rest in two campaigns of 21 days, and received a nutritional intervention (potassium bicarbonate 90 mmol/d) in a cross-over design. MRI measurements were performed 2 days before bed-rest, as well as one and five days after getting up. Image Segmentation and data analysis were conducted for the IVDs Th12/L1 to L5/S1. Results: 7 subjects, average age of 27.6 (SD 3.3) years, completed the study. Results showed a significant increase in T2-time in all IVDs (p < 0.001), more pronounced in the nucleus pulposus than in the annulus fibrosus (p<0.001). Oral potassium bicarbonate did not show an effect p=0.443). Pfirrmanngrade correlated with the T2-time (p<0.001). Conclusions: 6° head-down tilt bed-rest leads to a T2-time increase in lumbar IVDs. Oral potassium bicarbonate supplementation does not have an effect on IVD T2-time.

Item URL in elib:https://elib.dlr.de/114000/
Document Type:Article
Title:T2-relaxation time increases in lumbar intervertebral disks after 21d head-down tilt bed-rest
Authors:
AuthorsInstitution or Email of AuthorsAuthor's ORCID iDORCID Put Code
Koy, TimmoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ganse, BergitaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rittweger, JörnUNSPECIFIEDhttps://orcid.org/0000-0002-2223-8963UNSPECIFIED
Pohle-Fröhlich, Reginahochschule niederrhein, institute for pattern recognition, krefeldUNSPECIFIEDUNSPECIFIED
Frings-Meuthen, PetraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Johannes, Bernd WolfgangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Felsenberg, Dietercharité campus benjamin franklinUNSPECIFIEDUNSPECIFIED
Eysel, Peeruniversity of cologne, department of orthopaedic and trauma surgery, cologneUNSPECIFIEDUNSPECIFIED
Bansmann, Martinkrankenhaus porzUNSPECIFIEDUNSPECIFIED
Belavy, Daniel Ludoviccharité campus benjamin franklinUNSPECIFIEDUNSPECIFIED
Date:1 September 2017
Journal or Publication Title:Journal of Musculoskeletal and Neuronal Interactions
Refereed publication:Yes
Open Access:Yes
Gold Open Access:Yes
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:17
Page Range:pp. 140-145
Publisher:International Society of Musculoskeletal and Neuronal Interactions
ISSN:1108-7161
Status:Published
Keywords:MRI, Intervertebral Disc, Bed-rest, Back Pain, Space Flight
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - Vorhaben Systemphysiologie (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Muscle and Bone Metabolism
Deposited By: Becker, Christine
Deposited On:14 Sep 2017 12:50
Last Modified:14 Sep 2017 12:50

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