DLR-Logo -> http://www.dlr.de
DLR Portal Home | Imprint | Privacy Policy | Contact | Deutsch
Fontsize: [-] Text [+]

T2-relaxation time increases in lumbar intervertebral disks after 21d head-down tilt bed-rest

Koy, Timmo and Ganse, Bergita and Rittweger, Jörn and Pohle-Fröhlich, Regina and Frings-Meuthen, Petra and Johannes, Bernd Wolfgang and Felsenberg, Dieter and Eysel, Peer and Bansmann, Martin and Belavy, Daniel Ludovic (2017) T2-relaxation time increases in lumbar intervertebral disks after 21d head-down tilt bed-rest. Journal of Musculoskeletal and Neuronal Interactions, 17 (3), pp. 140-145. International Society of Musculoskeletal and Neuronal Interactions. ISSN 1108-7161.

[img] PDF


Objectives: Spaceflight back pain and intervertebral disc (IVD) herniations cause problems in astronauts. Purpose of this study was to assess changes in T2-relaxation-time through MRI measurements before and after head-down tilt bed-rest, a spaceflight analog. Methods: 8 men participated in the bed-rest study. Subjects remained in 6° head down tilt bed-rest in two campaigns of 21 days, and received a nutritional intervention (potassium bicarbonate 90 mmol/d) in a cross-over design. MRI measurements were performed 2 days before bed-rest, as well as one and five days after getting up. Image Segmentation and data analysis were conducted for the IVDs Th12/L1 to L5/S1. Results: 7 subjects, average age of 27.6 (SD 3.3) years, completed the study. Results showed a significant increase in T2-time in all IVDs (p < 0.001), more pronounced in the nucleus pulposus than in the annulus fibrosus (p<0.001). Oral potassium bicarbonate did not show an effect p=0.443). Pfirrmanngrade correlated with the T2-time (p<0.001). Conclusions: 6° head-down tilt bed-rest leads to a T2-time increase in lumbar IVDs. Oral potassium bicarbonate supplementation does not have an effect on IVD T2-time.

Item URL in elib:https://elib.dlr.de/114000/
Document Type:Article
Title:T2-relaxation time increases in lumbar intervertebral disks after 21d head-down tilt bed-rest
AuthorsInstitution or Email of AuthorsAuthor's ORCID iDORCID Put Code
Rittweger, JörnUNSPECIFIEDhttps://orcid.org/0000-0002-2223-8963UNSPECIFIED
Pohle-Fröhlich, Reginahochschule niederrhein, institute for pattern recognition, krefeldUNSPECIFIEDUNSPECIFIED
Felsenberg, Dietercharité campus benjamin franklinUNSPECIFIEDUNSPECIFIED
Eysel, Peeruniversity of cologne, department of orthopaedic and trauma surgery, cologneUNSPECIFIEDUNSPECIFIED
Bansmann, Martinkrankenhaus porzUNSPECIFIEDUNSPECIFIED
Belavy, Daniel Ludoviccharité campus benjamin franklinUNSPECIFIEDUNSPECIFIED
Date:1 September 2017
Journal or Publication Title:Journal of Musculoskeletal and Neuronal Interactions
Refereed publication:Yes
Open Access:Yes
Gold Open Access:Yes
In ISI Web of Science:Yes
Page Range:pp. 140-145
Publisher:International Society of Musculoskeletal and Neuronal Interactions
Keywords:MRI, Intervertebral Disc, Bed-rest, Back Pain, Space Flight
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - Vorhaben Systemphysiologie (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Muscle and Bone Metabolism
Deposited By: Becker, Christine
Deposited On:14 Sep 2017 12:50
Last Modified:14 Sep 2017 12:50

Repository Staff Only: item control page

Help & Contact
electronic library is running on EPrints 3.3.12
Website and database design: Copyright © German Aerospace Center (DLR). All rights reserved.