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High-intensity flywheel exercise and recovery of atrophy after 90 days bed-rest

Belavy, Daniel and Ohshima, Hiroshi and Rittweger, Jörn and Felsenberg, Dieter (2017) High-intensity flywheel exercise and recovery of atrophy after 90 days bed-rest. BMJ Open Sport & Exercise Medicine, 3 (1), e000196. BMJ Publishing Group. doi: 10.1136/bmjsem-2016-000196. ISSN 2055-7647.

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AIMS: To investigate differential muscle atrophy during bed-rest, the impact of a high-intensity concentric-eccentric (flywheel) resistance exercise countermeasure and muscle recovery after bed-rest. METHODS: Twenty-five healthy male subjects underwent 90 dayshead-down tilt bed-rest. Volume of individual lower-limb muscles was measured via MRI before, twice during and four times up to 1 year after bed-rest. Subjects were either inactive (n=16) or performed flywheel exercise every third day of bed-rest (n=9). Functional performance was assessed via countermovement jump. RESULTS: On 'intent-to-treat' analysis, flywheel prevented atrophy in the vasti (p<0.001) and reduced atrophy in the hip adductor/extensor adductor magnus (p=0.001) and ankle dorsiflexors/toe flexors (soleus (p<0.001), gastrocnemius medialis (p<0.001), gastrocnemius lateralis (p=0.02), and tibialis posterior with flexor digitorum longus (p=0.04)). Flywheel exercise was not effective for the hamstrings, gracilis, sartorius, peroneals and anterior tibial muscles. Muscle atrophy in vasti, soleus, gastrocnemius medialis, gastrocnemius lateralis and adductor magnus correlated with losses in countermovement jump performance. Muscle volume recovered within 90 days after bed-rest, however long-term after bed-rest, the inactive subjects only showed significantly increased muscle volume versus prebed-rest in a number of muscles including soleus (+4.3%), gastrocnemius medialis (+3.9%) and semimembranosus (+4.3%). This was not associated with greater countermovement jump performance. CONCLUSION: The exercise countermeasure was effective in preventing or reducing atrophy in the vasti, adductor magnus and ankle dorsiflexors/toe flexors but not the hamstrings, medial thigh muscles or peroneals and dorsiflexor muscles.

Item URL in elib:https://elib.dlr.de/113850/
Document Type:Article
Title:High-intensity flywheel exercise and recovery of atrophy after 90 days bed-rest
AuthorsInstitution or Email of AuthorsAuthor's ORCID iDORCID Put Code
Belavy, Danielcharité university medicine berlinUNSPECIFIEDUNSPECIFIED
Rittweger, JörnUNSPECIFIEDhttps://orcid.org/0000-0002-2223-8963UNSPECIFIED
Felsenberg, Dietercharité campus benjamin franklinUNSPECIFIEDUNSPECIFIED
Journal or Publication Title:BMJ Open Sport & Exercise Medicine
Refereed publication:Yes
Open Access:Yes
Gold Open Access:Yes
In ISI Web of Science:Yes
Page Range:e000196
Publisher:BMJ Publishing Group
Keywords:Exercise; Exercise rehabilitation; Muscle
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - Vorhaben Systemphysiologie (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Muscle and Bone Metabolism
Deposited By: Becker, Christine
Deposited On:05 Sep 2017 15:44
Last Modified:11 Jun 2021 04:12

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