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Membrane Fluidity Changes. A Basic Mechanism of Interaction of Gravity with Cells?

Kohn, Florian P. and Hauslage, Jens and Hanke, Wolfgang (2017) Membrane Fluidity Changes. A Basic Mechanism of Interaction of Gravity with Cells? Microgravity Science and Technology, 29, pp. 337-342. Springer. doi: 10.1007/s12217-017-9552-y. ISSN 0938-0108.

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Official URL: https://link.springer.com/article/10.1007/s12217-017-9552-y

Abstract

All life on earth has been established under conditions of stable gravity of 1g. Nevertheless, in numerous experiments the direct gravity dependence of biological processes has been shown on all levels of organization, from single molecules to humans. According to the underlying mechanisms a variety of questions, especially about gravity sensation of single cells without specialized organelles or structures for gravity sensing is being still open. Biological cell membranes are complex structures containing mainly lipids and proteins. Functional aspects of such membranes are usually attributed to membrane integral proteins. This is also correct for the gravity dependence of cells and organisms which is well accepted since long for a wide range of biological systems. However, it is as well established that parameters of the lipid matrix are directly modifying the function of proteins. Thus, the question must be asked, whether, and how far plain lipid membranes are affected by gravity directly. In principle it can be said that up to recently no real basic mechanism for gravity perception in single cells has been presented or verified. However, it now has been shown that as a basic membrane parameter, membrane fluidity, is significantly dependent on gravity. This finding might deliver a real basic mechanism for gravity perception of living organisms on all scales. In this review we summarize older and more recent results to demonstrate that the finding of membrane fluidity being gravity dependent is consistent with a variety of published laboratory experiments. We additionally point out to the consequences of these recent results for research in the field life science under space condition.

Item URL in elib:https://elib.dlr.de/113298/
Document Type:Article
Title:Membrane Fluidity Changes. A Basic Mechanism of Interaction of Gravity with Cells?
Authors:
AuthorsInstitution or Email of AuthorsAuthor's ORCID iDORCID Put Code
Kohn, Florian P.university of hohenheim, institute of physiology, stuttgart, germanyhttps://orcid.org/0000-0002-3127-3242UNSPECIFIED
Hauslage, Jensgerman aerospace centre (dlr), institute of aerospace medicine, gravitational biology, cologne, germanyhttps://orcid.org/0000-0003-2184-7000UNSPECIFIED
Hanke, Wolfganguniversity of hohenheim, institute of physiology, stuttgart, germanyhttps://orcid.org/0000-0003-0523-0588UNSPECIFIED
Date:22 June 2017
Journal or Publication Title:Microgravity Science and Technology
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:29
DOI:10.1007/s12217-017-9552-y
Page Range:pp. 337-342
Publisher:Springer
ISSN:0938-0108
Status:Published
Keywords:Gravity perception, Membrane fluidity, Alamethicin, Space pharmacology
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - Project eu:cropis (old), R - Vorhaben Biowissenschaftliche Exp.-vorbereitung (old), R - Vorhaben Biowissenschaftliche Nutzerunterstützung (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Gravitational Biology
Deposited By: Duwe, Helmut
Deposited On:30 Nov 2017 16:14
Last Modified:01 Oct 2020 21:15

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