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The functional muscle-bone unit in children with cerebral palsy

Duran, I. and Schütz, F. and Hamacher, S. and Semler, O. and Stark, C. and Schulze, J. and Rittweger, Jörn and Schoenau, E. (2017) The functional muscle-bone unit in children with cerebral palsy. Osteoporosis International, 28 (7), pp. 2081-2093. Springer. DOI: 10.1007/s00198-017-4023-2 ISSN 0937-941X

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Abstract

Our results suggest that the prevalence of bone health deficits in children with CP was overestimated, when using only age- and height-adjusted bone mineral content (BMC) and areal bone mineral density (aBMD). When applying the functional muscle-bone unit diagnostic algorithm (FMBU-A), the prevalence of positive results decreased significantly. We recommend applying the FMBU-A when assessing bone health in children with CP. INTRODUCTION: The prevalence of bone health deficits in children with cerebral palsy (CP) might be overestimated because age- and height-adjusted reference percentiles for bone mineral content (BMC) and areal bone mineral density (aBMD) assessed by dual-energy X-ray absorptiometry (DXA) do not consider reduced muscle activity. The aim of this study was to compare the prevalence of positive DXA-based indicators for bone health deficits in children with CP to the prevalence of positive findings after applying a functional muscle-bone unit diagnostic algorithm (FMBU-A) considering reduced muscle activity. METHODS: The present study was a monocentric retrospective analysis of 297 whole body DXA scans of children with CP. The prevalence of positive results of age- and height-adjusted BMC and aBMD defined as BMC and aBMD below the P3 percentile and of the FMBU-A was calculated. RESULTS: In children with CP, the prevalence of positive results of age-adjusted BMC were 33.3% and of aBMD 50.8%. Height-adjusted results for BMC and aBMD were positive in 16.8 and 36.0% of cases. The prevalence of positive results applying the FMBU-A regarding BMC and aBMD were significantly (p < 0.001) lower than using age- and height-adjusted BMC and aBMD (8.8 and 14.8%). CONCLUSIONS: Our results suggest that the prevalence of bone health deficits in children with CP was overestimated, when using age- and height-adjusted BMC and aBMD. When applying the FMBU-A, the prevalence decreased significantly. We recommend applying the FMBU-A when assessing bone health in children with CP.

Item URL in elib:https://elib.dlr.de/113057/
Document Type:Article
Title:The functional muscle-bone unit in children with cerebral palsy
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Duran, I.Center of Prevention and Rehabilitation, University of CologneUNSPECIFIED
Schütz, F.Center of Prevention and Rehabilitation, University of CologneUNSPECIFIED
Hamacher, S.Institute of Medical Statistics, Informatics and Epidemiology, University of CologneUNSPECIFIED
Semler, O.University of CologneUNSPECIFIED
Stark, C.University of CologneUNSPECIFIED
Schulze, J.Center of Prevention and Rehabilitation, University of CologneUNSPECIFIED
Rittweger, JörnJoern.Rittweger (at) dlr.dehttps://orcid.org/0000-0002-2223-8963
Schoenau, E.university childrens hospital, cologne, germanyUNSPECIFIED
Date:1 July 2017
Journal or Publication Title:Osteoporosis International
Refereed publication:Yes
Open Access:Yes
Gold Open Access:No
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:28
DOI :10.1007/s00198-017-4023-2
Page Range:pp. 2081-2093
Publisher:Springer
ISSN:0937-941X
Status:Published
Keywords:Cerebral palsy; Dual-energy X-ray absorptiometry; Fracture; Muscle-bone interactions; Osteoporosis
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Systemphysiologie
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Space Physiology
Deposited By: Becker, Christine
Deposited On:04 Jul 2017 12:51
Last Modified:06 Sep 2019 15:20

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