Versenden
Drucken
Duran, I. und Schütz, F. und Hamacher, S. und Semler, O. und Stark, C. und Schulze, J. und Rittweger, Jörn und Schoenau, E. (2017) The functional muscle-bone unit in children with cerebral palsy. Osteoporosis International, 28 (7), Seiten 2081-2093. Springer. doi: 10.1007/s00198-017-4023-2. ISSN 0937-941X.
Dieses Archiv kann nicht den Volltext zur Verfügung stellen.
Offizielle URL: https://link.springer.com/article/10.1007%2Fs00198-017-4023-2
Kurzfassung
Our results suggest that the prevalence of bone health deficits in children with CP was overestimated, when using only age- and height-adjusted bone mineral content (BMC) and areal bone mineral density (aBMD). When applying the functional muscle-bone unit diagnostic algorithm (FMBU-A), the prevalence of positive results decreased significantly. We recommend applying the FMBU-A when assessing bone health in children with CP. INTRODUCTION: The prevalence of bone health deficits in children with cerebral palsy (CP) might be overestimated because age- and height-adjusted reference percentiles for bone mineral content (BMC) and areal bone mineral density (aBMD) assessed by dual-energy X-ray absorptiometry (DXA) do not consider reduced muscle activity. The aim of this study was to compare the prevalence of positive DXA-based indicators for bone health deficits in children with CP to the prevalence of positive findings after applying a functional muscle-bone unit diagnostic algorithm (FMBU-A) considering reduced muscle activity. METHODS: The present study was a monocentric retrospective analysis of 297 whole body DXA scans of children with CP. The prevalence of positive results of age- and height-adjusted BMC and aBMD defined as BMC and aBMD below the P3 percentile and of the FMBU-A was calculated. RESULTS: In children with CP, the prevalence of positive results of age-adjusted BMC were 33.3% and of aBMD 50.8%. Height-adjusted results for BMC and aBMD were positive in 16.8 and 36.0% of cases. The prevalence of positive results applying the FMBU-A regarding BMC and aBMD were significantly (p < 0.001) lower than using age- and height-adjusted BMC and aBMD (8.8 and 14.8%). CONCLUSIONS: Our results suggest that the prevalence of bone health deficits in children with CP was overestimated, when using age- and height-adjusted BMC and aBMD. When applying the FMBU-A, the prevalence decreased significantly. We recommend applying the FMBU-A when assessing bone health in children with CP.
| elib-URL des Eintrags: | https://elib.dlr.de/113057/ | ||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dokumentart: | Zeitschriftenbeitrag | ||||||||||||||||||||||||||||||||||||
| Titel: | The functional muscle-bone unit in children with cerebral palsy | ||||||||||||||||||||||||||||||||||||
| Autoren: |
| ||||||||||||||||||||||||||||||||||||
| Datum: | 1 Juli 2017 | ||||||||||||||||||||||||||||||||||||
| Erschienen in: | Osteoporosis International | ||||||||||||||||||||||||||||||||||||
| Referierte Publikation: | Ja | ||||||||||||||||||||||||||||||||||||
| Open Access: | Ja | ||||||||||||||||||||||||||||||||||||
| Gold Open Access: | Nein | ||||||||||||||||||||||||||||||||||||
| In SCOPUS: | Ja | ||||||||||||||||||||||||||||||||||||
| In ISI Web of Science: | Ja | ||||||||||||||||||||||||||||||||||||
| Band: | 28 | ||||||||||||||||||||||||||||||||||||
| DOI: | 10.1007/s00198-017-4023-2 | ||||||||||||||||||||||||||||||||||||
| Seitenbereich: | Seiten 2081-2093 | ||||||||||||||||||||||||||||||||||||
| Verlag: | Springer | ||||||||||||||||||||||||||||||||||||
| ISSN: | 0937-941X | ||||||||||||||||||||||||||||||||||||
| Status: | veröffentlicht | ||||||||||||||||||||||||||||||||||||
| Stichwörter: | Cerebral palsy; Dual-energy X-ray absorptiometry; Fracture; Muscle-bone interactions; Osteoporosis | ||||||||||||||||||||||||||||||||||||
| HGF - Forschungsbereich: | Luftfahrt, Raumfahrt und Verkehr | ||||||||||||||||||||||||||||||||||||
| HGF - Programm: | Raumfahrt | ||||||||||||||||||||||||||||||||||||
| HGF - Programmthema: | Forschung unter Weltraumbedingungen | ||||||||||||||||||||||||||||||||||||
| DLR - Schwerpunkt: | Raumfahrt | ||||||||||||||||||||||||||||||||||||
| DLR - Forschungsgebiet: | R FR - Forschung unter Weltraumbedingungen | ||||||||||||||||||||||||||||||||||||
| DLR - Teilgebiet (Projekt, Vorhaben): | R - Vorhaben Systemphysiologie (alt) | ||||||||||||||||||||||||||||||||||||
| Standort: | Köln-Porz | ||||||||||||||||||||||||||||||||||||
| Institute & Einrichtungen: | Institut für Luft- und Raumfahrtmedizin > Weltraumphysiologie | ||||||||||||||||||||||||||||||||||||
| Hinterlegt von: | Becker, Christine | ||||||||||||||||||||||||||||||||||||
| Hinterlegt am: | 04 Jul 2017 12:51 | ||||||||||||||||||||||||||||||||||||
| Letzte Änderung: | 01 Okt 2020 19:48 |
Nur für Mitarbeiter des Archivs: Kontrollseite des Eintrags
