elib
DLR-Header
DLR-Logo -> http://www.dlr.de
DLR Portal Home | Imprint | Privacy Policy | Contact | Deutsch
Fontsize: [-] Text [+]

Impact of Gravity on Thyroid Cells

Albi, Elisabetta and Krüger, Marcus and Hemmersbach, Ruth and Lazzarini, Andrea and Cataldi, Samuela and Codini, Michela and Beccari, Tommaso and Ambesi-Impiombato, Francesco Saverio and Curcio, Francesco (2017) Impact of Gravity on Thyroid Cells. International Journal of Molecular Sciences, 18 (5), pp. 1-14. Multidisciplinary Digital Publishing Institute (MDPI). DOI: 10.3390/ijms18050972 ISSN 1661-6596

[img] PDF
1MB

Official URL: http://www.mdpi.com/1422-0067/18/5/972

Abstract

Physical and mental health requires a correct functioning of the thyroid gland, which controls cardiovascular, musculoskeletal, nervous, and immune systems, and affects behavior and cognitive functions. Microgravity, as occurs during space missions, induces morphological and functional changes within the thyroid gland. Here, we review relevant experiments exposing cell cultures (normal and cancer thyroid cells) to simulated and real microgravity, as well as wild-type and transgenic mice to hypergravity and spaceflight conditions. Well-known mechanisms of damage are presented and new ones, such as changes of gene expression for extracellular matrix and cytoskeleton proteins, thyrocyte phenotype, sensitivity of thyrocytes to thyrotropin due to thyrotropin receptor modification, parafollicular cells and calcitonin production, sphingomyelin metabolism, and the expression and movement of cancer molecules from thyrocytes to colloids are highlighted. The identification of new mechanisms of thyroid injury is essential for the development of countermeasures, both on the ground and in space, against thyroid cancer. We also address the question whether normal and cancer cells show a different sensitivity concerning changes of environmental conditions.

Item URL in elib:https://elib.dlr.de/112810/
Document Type:Article
Title:Impact of Gravity on Thyroid Cells
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Albi, ElisabettaUniversity of Perugia, Department of Pharmaceutical Science, Perugia, ItalyUNSPECIFIED
Krüger, MarcusOtto-von-Guericke-University, Clinic and Policlinic for Plastic, Aesthetic and Hand Surgery,UNSPECIFIED
Hemmersbach, Ruthgerman aerospace center (dlr), institute of aerospace medicine, gravitational biology, cologne, germanyhttps://orcid.org/0000-0001-5308-6715
Lazzarini, AndreaLaboratory of Nuclear Lipid BioPathology, CRABiON, Perugia, ItalyUNSPECIFIED
Cataldi, SamuelaUniversity of Perugia, Department of Pharmaceutical Science, Perugia, ItalyUNSPECIFIED
Codini, MichelaUniversity of Perugia, Department of Pharmaceutical Science, Perugia, ItalyUNSPECIFIED
Beccari, TommasoUniversity of Perugia, Department of Pharmaceutical Science, Perugia, ItalyUNSPECIFIED
Ambesi-Impiombato, Francesco SaverioUniversity of Udine, Dipartimento di Area Medica (DAME), Udine, ItalyUNSPECIFIED
Curcio, FrancescoUniversity of Udine, Dipartimento di Area Medica (DAME), Udine, ItalyUNSPECIFIED
Date:4 May 2017
Journal or Publication Title:International Journal of Molecular Sciences
Refereed publication:Yes
Open Access:Yes
Gold Open Access:Yes
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:18
DOI :10.3390/ijms18050972
Page Range:pp. 1-14
Publisher:Multidisciplinary Digital Publishing Institute (MDPI)
ISSN:1661-6596
Status:Published
Keywords:thyroid gland, thyroid cancer, microgravity, hypergravity, space environment
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Biowissenschaftliche Exp.-vorbereitung, R - Vorhaben Biowissenschaftliche Nutzerunterstützung
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Gravitational Biology
Deposited By: Duwe, Helmut
Deposited On:28 Jun 2017 12:45
Last Modified:08 Mar 2018 18:40

Repository Staff Only: item control page

Browse
Search
Help & Contact
Information
electronic library is running on EPrints 3.3.12
Copyright © 2008-2017 German Aerospace Center (DLR). All rights reserved.