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Glucose Tolerance after different Sleep Regimes: Effects of Sleep Deprivation, Sleep Restriction, and Recovery

Elmenhorst, Eva-Maria and Hennecke, E. and Lange, D. and Fronczek, J. and Bauer, A. and Elmenhorst, D. and Aeschbach, D. (2017) Glucose Tolerance after different Sleep Regimes: Effects of Sleep Deprivation, Sleep Restriction, and Recovery. In: Sleep, Volume 40 Supplement 1, 2017, A27-A28. Sleep 2017, 03.-07.06.2017, Boston.

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Abstract

Introduction: Shift-work is related to metabolic and cardiovascular disease. Sleep restriction and circadian misalignment have been shown to decrease glucose tolerance. Since shift-work is often associated with a combination of sleep restriction, total sleep deprivation and intermittent recovery sleep we tested (i) whether acute sleep deprivation and repeated sleep restriction exhibit similar effects on glucose tolerance, (ii) whether one night of recovery sleep after repeated sleep restriction is sufficient to restore glucose tolerance, and (iii) whether the effects of acute sleep deprivation and prior sleep restriction are cumulative. Methods: Morning oral glucose tolerance (OGTT: 75g dextrose/300ml water; >10h fasting) was tested during a 12-day inpatient study in an intervention group (IG) (N=18; 9 females, mean age 26±3 years, BMI 23.2±2.0) and a control group (CG) (N=9; 3 females, mean age 25±5 years, BMI 23.5±3.4). In the IG OGTTs were run after (i) two nights of baseline sleep (8h TIB), (ii) five nights of sleep restriction (5h TIB), (iii) one night of recovery (8h TIB), and (iv) 24h of sustained wakefulness following recovery. In the CG OGTTs were taken at the same time points except that TIB was 8h for all sleep episodes. Blood samples were taken immediately prior to the OGTT and every 30min thereafter for 120min. Mixed ANOVAs with Tukey adjustment compared glucose levels in each group between interventions. Results: Glucose tolerance decreased after five nights of sleep restriction: compared to baseline, blood glucose stayed elevated 60min (Δ19.1±6.2 mg/dl (SE), p<0.02), 90min (Δ25.6±6.0 mg/dl, p=0.0005), and 120min (Δ24.8±5.1 mg/dl, p<0.0001) after intake. Glucose levels were still increased after recovery (90min: Δ22.6±6.0 mg/dl, p=0.002; 120min: Δ16.2±5.1 mg/dl, p<0.02), but were not different from baseline after 24h of wakefulness. Sleep deprivation in the CG did not alter glucose tolerance. Conclusion: Restricting the sleep time to 5h for five nights decreased glucose tolerance. One 8h recovery sleep episode did not restore glucose tolerance. One night of sleep deprivation did not affect glucose tolerance and did not add to the effects of prior sleep restriction. A different metabolic regulation during the wake state might have prevented glucose tolerance from decreasing.

Item URL in elib:https://elib.dlr.de/112778/
Document Type:Conference or Workshop Item (Speech)
Title:Glucose Tolerance after different Sleep Regimes: Effects of Sleep Deprivation, Sleep Restriction, and Recovery
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Elmenhorst, Eva-MariaEva-Maria.Elmenhorst (at) dlr.dehttps://orcid.org/0000-0003-0336-6705
Hennecke, E.eva.hennecke (at) dlr.deUNSPECIFIED
Lange, D.denise.lange (at) dlr.deUNSPECIFIED
Fronczek, J.UNSPECIFIEDUNSPECIFIED
Bauer, A.UNSPECIFIEDUNSPECIFIED
Elmenhorst, D.UNSPECIFIEDUNSPECIFIED
Aeschbach, D.daniel.aeschbach (at) dlr.deUNSPECIFIED
Date:2017
Journal or Publication Title:Sleep, Volume 40 Supplement 1, 2017, A27-A28
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In SCOPUS:No
In ISI Web of Science:No
Status:Published
Keywords:Glucose tolerance, sleep restriction, sleep deprivation, recovery, insulin sensitivity
Event Title:Sleep 2017
Event Location:Boston
Event Type:international Conference
Event Dates:03.-07.06.2017
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:other
DLR - Research area:Raumfahrt
DLR - Program:R - no assignment
DLR - Research theme (Project):R - no assignment
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Flight Physiology
Deposited By: Sender, Alina
Deposited On:22 Jun 2017 09:49
Last Modified:01 Dec 2018 19:52

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