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Recovery sleep after extended wakefulness restores elevated A1 adenosine receptor availability in the human brain.

Elmenhorst, D. and Elmenhorst, Eva-Maria and Hennecke, E. and Kroll, T. and Matusch, A. and Aeschbach, D. and Bauer, A. (2017) Recovery sleep after extended wakefulness restores elevated A1 adenosine receptor availability in the human brain. Proceedings of the National Academy of Science (PNAS), 114 (16), pp. 4243-4248. National Academy of Sciences. DOI: 10.1073/pnas.1614677114 ISSN 0027-8424

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Abstract

Adenosine and functional A1 adenosine receptor (A1AR) availability are supposed to mediate sleep-wake regulation and cognitive performance. We hypothesized that cerebral A1AR availability after an extended wake period decreases to a well-rested state after recovery sleep. [18F]CPFPX positron emission tomography was used to quantify A1AR availability in 15 healthy male adults after 52 h of sleep deprivation and following 14 h of recovery sleep. Data were additionally compared with A1AR values after 8 h of baseline sleep from an earlier dataset. Polysomnography, cognitive performance, and sleepiness were monitored. Recovery from sleep deprivation was associated with a decrease in A1AR availability in several brain regions, ranging from 11% (insula) to 14% (striatum). A1AR availabilities after recovery did not differ from baseline sleep in the control group. The degree of performance impairment, sleepiness, and homeostatic sleep-pressure response to sleep deprivation correlated negatively with the decrease in A1AR availability. Sleep deprivation resulted in a higher A1AR availability in the human brain. The increase that was observed after 52 h of wakefulness was restored to control levels during a 14-h recovery sleep episode. Individuals with a large increase in A1AR availability were more resilient to sleep-loss effects than those with a subtle increase. This pattern implies that differences in endogenous adenosine and A1AR availability might be causal for individual responses to sleep loss.

Item URL in elib:https://elib.dlr.de/112775/
Document Type:Article
Title:Recovery sleep after extended wakefulness restores elevated A1 adenosine receptor availability in the human brain.
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Elmenhorst, D.UNSPECIFIEDUNSPECIFIED
Elmenhorst, Eva-Mariaeva-maria.elmenhorst (at) dlr.dehttps://orcid.org/0000-0003-0336-6705
Hennecke, E.eva.hennecke (at) dlr.deUNSPECIFIED
Kroll, T.UNSPECIFIEDUNSPECIFIED
Matusch, A.UNSPECIFIEDUNSPECIFIED
Aeschbach, D.daniel.aeschbach (at) dlr.deUNSPECIFIED
Bauer, A.UNSPECIFIEDUNSPECIFIED
Date:2017
Journal or Publication Title:Proceedings of the National Academy of Science (PNAS)
Refereed publication:Yes
Open Access:Yes
Gold Open Access:No
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:114
DOI :10.1073/pnas.1614677114
Page Range:pp. 4243-4248
Publisher:National Academy of Sciences
ISSN:0027-8424
Status:Published
Keywords:cognitive Performance, Depression, interindividual differences, sleep deprivation, sleep homeostasis
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Aeronautics
HGF - Program Themes:air traffic management and operations
DLR - Research area:Aeronautics
DLR - Program:L AO - Air Traffic Management and Operation
DLR - Research theme (Project):L - Human factors and safety in Aeronautics
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Flight Physiology
Deposited By: Sender, Alina
Deposited On:18 Aug 2017 10:08
Last Modified:31 Jul 2019 20:10

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