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Gravireceptors in eukaryotes - a comparison of case studies on the cellular level

Häder, Donat-Peter and Braun, Markus and Grimm, Daniela and Hemmersbach, Ruth (2017) Gravireceptors in eukaryotes - a comparison of case studies on the cellular level. npj Microgravity, 3 (13), pp. 1-8. Nature Publishing Group. DOI: 10.1038/s41526-017-0018-8 ISSN 2373-8065

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Official URL: http://www.nature.com/articles/s41526-017-0018-8

Abstract

We have selected five evolutionary very different biological systems ranging from unicellular protists via algae and higher plants to human cells showing responses to the gravity vector of the Earth in order to compare their graviperception mechanisms. All these systems use a mass, which may either by a heavy statolith or the whole content of the cell heavier than the surrounding medium to operate on a gravireceptor either by exerting pressure or by pulling on a cytoskeletal element. In many cases the receptor seems to be a mechanosensitive ion channel activated by the gravitational force which allows a gated ion flux across the membrane when activated. This has been identified in many systems to be a calcium current, which in turn activates subsequent elements of the sensory transduction chain, such as calmodulin, which in turn results in the activation of ubiquitous enzymes, gene expression activation or silencing. Naturally, the subsequent responses to the gravity stimulus differ widely between the systems ranging from orientational movement and directed growth to physiological reactions and adaptation to the environmental conditions.

Item URL in elib:https://elib.dlr.de/112741/
Document Type:Article
Title:Gravireceptors in eukaryotes - a comparison of case studies on the cellular level
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Häder, Donat-PeterEmeritus from friedrich-alexander-universität erlangen, institut für biologiehttps://orcid.org/0000-0002-4295-5660
Braun, Markusuniversity of bonn, institute of molecular physiology and biotechnology of plants, bonn, germanyUNSPECIFIED
Grimm, Danielaaarhus university, department of biomedicine, aarhus, denmarkhttps://orcid.org/0000-0002-5083-2812
Hemmersbach, Ruthgerman aerospace centre (dlr), institute of aerospace medicine, gravitational biology, cologne, germanyhttps://orcid.org/0000-0001-5308-6715
Date:28 April 2017
Journal or Publication Title:npj Microgravity
Refereed publication:Yes
Open Access:Yes
Gold Open Access:Yes
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:3
DOI :10.1038/s41526-017-0018-8
Page Range:pp. 1-8
Publisher:Nature Publishing Group
ISSN:2373-8065
Status:Published
Keywords:Gravireceptors, eukaryotes, cellular level, evolution, Euglena, Loxodes, Chara rhizoids, Arabidopsis roots, human cells
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Biowissenschaftliche Exp.-vorbereitung, R - Vorhaben Biowissenschaftliche Nutzerunterstützung
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Gravitational Biology
Deposited By: Duwe, Helmut
Deposited On:22 Jun 2017 09:52
Last Modified:17 Nov 2018 05:02

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