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Protective signaling pathways in the cellular radiation response: Nuclear Factor κB (NF-κB) and Nrf2

Henschenmacher, B. and Crellin, A. J. and Enyong, E. and Chishti, A. A. and Diegeler, S. and Spitta, L. F. and Koch, K. and Konda, B. and Feles, S. and Schmitz, C. and Baumstark, C. and Hellweg, Christine E. (2017) Protective signaling pathways in the cellular radiation response: Nuclear Factor κB (NF-κB) and Nrf2. ConRad 2017: 22nd Nuclear Medical Defense Conference, 8.-11. Mai 2017, München, Germany.

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Abstract

As a prerequisite for developing appropriate countermeasures to mitigate acute effects and late risks of ionizing radiation exposure, the role of protective pathways in the cellular radiation response needs to be better understood. The Nuclear Factor κB (NF-κB) pathway is generally regarded as protective by upregulating anti-apoptotic genes and is known to be activated by DNA double strand breaks. The transcription factor Nuclear Factor Erythroid 2 Like 2 (Nrf2) is activated in response to oxidative stress and increases the expression of anti-oxidative enzymes. In this work, the production of reactive oxygen species (ROS), the activation of NF-κB and Nrf2 and the expression of selected target genes after ionizing radiation exposure (X-rays, heavy ions) were analyzed in human cell lines.

Item URL in elib:https://elib.dlr.de/112412/
Document Type:Conference or Workshop Item (Poster)
Title:Protective signaling pathways in the cellular radiation response: Nuclear Factor κB (NF-κB) and Nrf2
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Henschenmacher, B.german aerospace centre (dlr), institute of aerospace medicine, radiation biology department, linder höhe, d-51147 köln, germanyUNSPECIFIED
Crellin, A. J.radiation biology department, institute of aerospace medicine, german aerospace center (dlr), cologne, germany.UNSPECIFIED
Enyong, E.radiation biology department, institute of aerospace medicine, german aerospace center (dlr), cologne, germany.UNSPECIFIED
Chishti, A. A.radiation biology department, institute of aerospace medicine, german aerospace center (dlr), cologne, germany. Present address: The Karachi Institute of Biotechnology and Genetic Engineering (KIBGE), University of Karachi, 75270 Karachi, PakistanUNSPECIFIED
Diegeler, S.radiation biology department, institute of aerospace medicine, german aerospace center (dlr), cologne, germany.UNSPECIFIED
Spitta, L. F.radiation biology department, institute of aerospace medicine, german aerospace center (dlr), cologne, germany.UNSPECIFIED
Koch, K.radiation biology department, institute of aerospace medicine, german aerospace center (dlr), cologne, germany.UNSPECIFIED
Konda, B.radiation biology department, institute of aerospace medicine, german aerospace center (dlr), cologne, germany.UNSPECIFIED
Feles, S.radiation biology department, institute of aerospace medicine, german aerospace center (dlr), cologne, germany.UNSPECIFIED
Schmitz, C.radiation biology department, institute of aerospace medicine, german aerospace center (dlr), cologne, germany.UNSPECIFIED
Baumstark, C.radiation biology department, institute of aerospace medicine, german aerospace center (dlr), cologne, germany.UNSPECIFIED
Hellweg, Christine E.radiation biology department, institute of aerospace medicine, german aerospace center (dlr), cologne, germany.https://orcid.org/0000-0002-2223-3580
Date:2017
Refereed publication:Yes
Open Access:Yes
Gold Open Access:No
In SCOPUS:No
In ISI Web of Science:No
Status:Published
Keywords:Nuclear Factor κB (NF-κB), cellular radiation Response, human cell lines
Event Title:ConRad 2017: 22nd Nuclear Medical Defense Conference
Event Location:München, Germany
Event Type:international Conference
Event Dates:8.-11. Mai 2017
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Strahlenbiologie
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Radiation Biology
Deposited By: Kopp, Kerstin
Deposited On:14 Jun 2017 13:24
Last Modified:31 Jul 2019 20:09

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