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Markers of bone metabolism during 14 days of bed rest in young and older men

Bühlmeier, J. and Frings-Meuthen, P. and Mohorko, N. and Lau, P. and Mazzucco, S. and Ferretti, J.L. and Biolo, G. and Pisot, R. and Simunic, B. and Rittweger, J. (2017) Markers of bone metabolism during 14 days of bed rest in young and older men. Journal of Musculoskeletal and Neuronal Interactions, 17 (1), pp. 399-408. International Society of Musculoskeletal and Neuronal Interactions. ISSN 1108-7161.

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Objective: We aimed at comparing markers of bone metabolism during unloading in young and older men, and to assess countermeasure effectiveness. Methods: 16 older (60±2 years) and 8 younger men (23±3 years) underwent bed rest (BR) for 14 days. A subgroup of the Older performed cognitive training during BR and supplemented Protein and potassium bicarbonate afterwards. Biochemical markers of bone and calcium/phosphate metabolism were assessed. Results: At baseline urinary NTX and CTX were greater in younger than in older subjects (P<0.001), but increased during BR (P<0.001) by a similar amount (P>0.17). P1NP was greater in young than in older subjects (P<0.001) and decreased during BR in the Young (P<0.001). Sclerostin increased during BR across groups (P=0.016). No systematic effects of the countermeasure were observed. Conclusion: In men, older age did not affect control of bone metabolism, but bone turnover was reduced. During BR formation markers were reduced only in younger men whereas resorption markers increased to a comparable extent. Thus, we assume that older men are not at an elevated, and possibly even at a reduced risk to lose bone when immobilized.

Item URL in elib:https://elib.dlr.de/111805/
Document Type:Article
Title:Markers of bone metabolism during 14 days of bed rest in young and older men
AuthorsInstitution or Email of AuthorsAuthor's ORCID iD
Bühlmeier, J.Judith.Buehlmeier (at) dlr.deUNSPECIFIED
Frings-Meuthen, P.Petra.Frings-Meuthen (at) dlr.deUNSPECIFIED
Mohorko, N.university of primorskaUNSPECIFIED
Lau, P.radiation biology department, german aerospace center (dlr), institute of aerospace medicine, linder hoehe, 51147 cologne (köln), germanyUNSPECIFIED
Mazzucco, S.university of triesteUNSPECIFIED
Ferretti, J.L.center of p-ca metabolism studies (cemfoc), jlferretti (at) arnet.com.arUNSPECIFIED
Biolo, G.department of clinical, technological and morphological sciences, division of internal medicine, university triest, italienUNSPECIFIED
Pisot, R.university of primorskaUNSPECIFIED
Simunic, B.university of primorskaUNSPECIFIED
Rittweger, J.joern.rittweger (at) dlr.dehttps://orcid.org/0000-0002-2223-8963
Date:9 January 2017
Journal or Publication Title:Journal of Musculoskeletal and Neuronal Interactions
Refereed publication:Yes
Open Access:Yes
Gold Open Access:Yes
In ISI Web of Science:Yes
Page Range:pp. 399-408
EditorsEmailEditor's ORCID iD
Publisher:International Society of Musculoskeletal and Neuronal Interactions
Keywords:Mechano-adaptation, Age effects, Immobilization, Wnt-signalling, Countermeasure
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - Vorhaben Integrative Studien (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Space Physiology
Deposited By: Becker, Christine
Deposited On:04 Apr 2017 13:33
Last Modified:16 Jan 2019 12:01

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