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Temporal dynamics of the gut microbiota in people sharing a confined environment, a 520-day ground-based space simulation, MARS500

Turroni, Silvia and Rampelli, Simone and Biagi, Elena and Consolandi, Clarissa and Severgnini, Marco and Peano, Clelia and Quercia, Sara and Soverini, Matteo and Carbonero, Franck G. and Bianconi, Giovanna and Rettberg, Petra and Canganella, Francesco and Brigidi, Patrizia and Candela, Marco (2017) Temporal dynamics of the gut microbiota in people sharing a confined environment, a 520-day ground-based space simulation, MARS500. Microbiome, 5 (1). BioMed Central. DOI: 10.1186/s40168-017-0256-8 ISSN 2049-2618

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Official URL: http://dx.doi.org/10.1186/s40168-017-0256-8

Abstract

Background: The intestinal microbial communities and their temporal dynamics are gaining increasing interest due to the significant implications for human health. Recent studies have shown the dynamic behavior of the gut microbiota in free-living, healthy persons. To date, it is not known whether these dynamics are applicable during prolonged life sharing in a confined and controlled environment. Results: The MARS500 project, the longest ground-based space simulation ever, provided us with a unique opportunity to trace the crew microbiota over 520 days of isolated confinement, such as that faced by astronauts in real long-term interplanetary space flights, and after returning to regular life, for a total of 2 years. According to our data, even under the strictly controlled conditions of an enclosed environment, the human gut microbiota is inherently dynamic, capable of shifting between different steady states, typically with rearrangements of autochthonous members. Notwithstanding a strong individuality in the overall gut microbiota trajectory, some key microbial components showed conserved temporal dynamics, with potential implications for the maintenance of a health-promoting, mutualistic microbiota configuration. Conclusions: Sharing life in a confined habitat does not affect the resilience of the individual gut microbial ecosystem, even in the long term. However, the temporal dynamics of certain microbiota components should be monitored when programming future mission simulations and real space flights, to prevent breakdowns in the metabolic and immunological homeostasis of the crewmembers.

Item URL in elib:https://elib.dlr.de/111692/
Document Type:Article
Additional Information:http://rdcu.be/JII3 (Direkt-Link)
Title:Temporal dynamics of the gut microbiota in people sharing a confined environment, a 520-day ground-based space simulation, MARS500
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Turroni, SilviaUnit of Microbial Ecology of Health, Department of Pharmacy and Biotechnology, University of Bologna, Bologna 40126, Italy; silvia.turroni (at) unibo.itUNSPECIFIED
Rampelli, SimoneUnit of Microbial Ecology of Health, Department of Pharmacy and Biotechnology, University of Bologna, Bologna 40126, ItalyUNSPECIFIED
Biagi, ElenaUnit of Microbial Ecology of Health, Department of Pharmacy and Biotechnology, University of Bologna, Bologna 40126, ItalyUNSPECIFIED
Consolandi, ClarissaInstitute of Biomedical Technologies – National Research Council (ITB-CNR), Segrate, Milan 20090, ItalyUNSPECIFIED
Severgnini, MarcoInstitute of Biomedical Technologies – National Research Council (ITB-CNR), Segrate, Milan 20090, ItalyUNSPECIFIED
Peano, CleliaInstitute of Biomedical Technologies – National Research Council (ITB-CNR), Segrate, Milan 20090, ItalyUNSPECIFIED
Quercia, SaraUnit of Microbial Ecology of Health, Department of Pharmacy and Biotechnology, University of Bologna, Bologna 40126, ItalyUNSPECIFIED
Soverini, MatteoUnit of Microbial Ecology of Health, Department of Pharmacy and Biotechnology, University of Bologna, Bologna 40126, ItalyUNSPECIFIED
Carbonero, Franck G.Department of Food Science, University of Arkansas, Fayetteville, AR 72704, USA.UNSPECIFIED
Bianconi, GiovannaDepartment for Innovation in Biological, Agrofood, and Forest Systems, University of Tuscia, Viterbo 01100, ItalyUNSPECIFIED
Rettberg, Petraradiation biology department, institute of aerospace medicine, german aerospace center (dlr), cologne, germany; petra.rettberg (at) dlr.dehttps://orcid.org/0000-0003-4439-2395
Canganella, FrancescoDepartment for Innovation in Biological, Agrofood, and Forest Systems, University of Tuscia, Viterbo 01100, ItalyUNSPECIFIED
Brigidi, PatriziaUnit of Microbial Ecology of Health, Department of Pharmacy and Biotechnology, University of Bologna, Bologna 40126, ItalyUNSPECIFIED
Candela, MarcoUnit of Microbial Ecology of Health, Department of Pharmacy and Biotechnology, University of Bologna, Bologna 40126, Italy; marco.candela (at) unibo.itUNSPECIFIED
Date:2017
Journal or Publication Title:Microbiome
Refereed publication:Yes
Open Access:Yes
Gold Open Access:Yes
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:5
DOI :10.1186/s40168-017-0256-8
Publisher:BioMed Central
ISSN:2049-2618
Status:Published
Keywords:MARS500, Gut microbiota, Temporal dynamics, Life sharing, Confined environment, Space flight, Resilience
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Strahlenbiologie
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Radiation Biology
Deposited By: Kopp, Kerstin
Deposited On:05 Apr 2017 16:47
Last Modified:26 Mar 2018 10:58

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