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ROLE OF NUCLEAR FACTOR κB (NF-κB) IN THE CELLULAR RESPONSE TO HEAVY IONS EXPOSURE

Hellweg, Christine E. and Koch, K. and Spitta, L.F. and Chishti, A.A. and Henschenmacher, B. and Diegeler, S. and Konda, B. and Feles, S. and Schmitz, C. and Baumstark-Khan, C. (2017) ROLE OF NUCLEAR FACTOR κB (NF-κB) IN THE CELLULAR RESPONSE TO HEAVY IONS EXPOSURE. OPERRA Workshop - Radiation effects on the immune system: an updated state of the art and future research needs, 7–9 March, 2017, Budapest, Hungary.

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Abstract

Introduction: As a prerequisite for developing appropriate countermeasures to mitigate acute effects and late radiation risks for the astronaut and thereby enabling long-term human space flight, the cellular radiation response to densely ionizing radiation needs to be better understood. The biological effectiveness of accelerated heavy ions (which constitute the biologically most important radiation type in space) with high linear energy transfer (LET) for effecting DNA damage response pathways as a gateway to cell death or survival is of major concern not only for space missions but also for new regimes of tumor radiotherapy.

Item URL in elib:https://elib.dlr.de/111671/
Document Type:Conference or Workshop Item (Speech)
Title:ROLE OF NUCLEAR FACTOR κB (NF-κB) IN THE CELLULAR RESPONSE TO HEAVY IONS EXPOSURE
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Hellweg, Christine E.german aerospace centre (dlr), institute of aerospace medicine, radiation biology department, linder höhe, d-51147 köln, germanyhttps://orcid.org/0000-0002-2223-3580
Koch, K.german aerospace centre (dlr), institute of aerospace medicine, radiation biology department, linder höhe, d-51147 köln, germanyUNSPECIFIED
Spitta, L.F.german aerospace centre (dlr), institute of aerospace medicine, radiation biology department, linder höhe, d-51147 köln, germanyUNSPECIFIED
Chishti, A.A.german aerospace centre (dlr), institute of aerospace medicine, radiation biology department, linder höhe, d-51147 köln, germany; The Karachi Institute of Biotechnology and Genetic Engineering (KIBGE), University of Karachi, 75270 Karachi, PakistanUNSPECIFIED
Henschenmacher, B.german aerospace centre (dlr), institute of aerospace medicine, radiation biology department, linder höhe, d-51147 köln, germanyUNSPECIFIED
Diegeler, S.german aerospace centre (dlr), institute of aerospace medicine, radiation biology department, linder höhe, d-51147 köln, germanyUNSPECIFIED
Konda, B.german aerospace centre (dlr), institute of aerospace medicine, radiation biology department, linder höhe, d-51147 köln, germanyUNSPECIFIED
Feles, S.german aerospace centre (dlr), institute of aerospace medicine, radiation biology department, linder höhe, d-51147 köln, germanyUNSPECIFIED
Schmitz, C.german aerospace centre (dlr), institute of aerospace medicine, radiation biology department, linder höhe, d-51147 köln, germanyUNSPECIFIED
Baumstark-Khan, C.german aerospace centre (dlr), institute of aerospace medicine, radiation biology department, linder höhe, d-51147 köln, germanyUNSPECIFIED
Date:2017
Refereed publication:Yes
Open Access:Yes
Gold Open Access:No
In SCOPUS:No
In ISI Web of Science:No
Status:Published
Keywords:NF-κB, cellular response, X-rays, heavy ions
Event Title:OPERRA Workshop - Radiation effects on the immune system: an updated state of the art and future research needs
Event Location:Budapest, Hungary
Event Type:Workshop
Event Dates:7–9 March, 2017
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Strahlenbiologie
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Radiation Biology
Deposited By: Kopp, Kerstin
Deposited On:05 Apr 2017 16:50
Last Modified:31 Jul 2019 20:08

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