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Tune It Down to Live It Up? Rapid, Nongenomic Effects of Cortisol on the Human Brain

Strelzyk, Florian and Hermes, Michael and Naumann, Ewald and Oitzl, Melly and Walter, Christoph and Busch, Hans-Peter and Richter, Steffen and Schächinger, Hartmut (2012) Tune It Down to Live It Up? Rapid, Nongenomic Effects of Cortisol on the Human Brain. Journal of Neuroscience, 32 (2), pp. 616-624. Society for Neuroscience. DOI: 10.1523/JNEUROSCI.2384-11.2012 ISBN 0270-6474 ISSN 0270-6474

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Abstract

The stress hormone cortisol acts on the brain, supporting adaptation and time-adjusted coping processes. Whereas previous research has focused on slow emerging, genomic effects of cortisol, we addressed the rapid, nongenomic cortisol effects on in vivo neuronal activity in humans. Three independent placebo-controlled studies in healthy men were conducted. We observed changes in CNS activity within 15 min after intravenous administration of a physiological dose of 4 mg of cortisol (hydrocortisone). Two of the studies demonstrated a rapid bilateral thalamic perfusion decrement using continuous arterial spin labeling. The third study revealed rapid, cortisol-induced changes in global signal strength and map dissimilarity of the electroencephalogram. Our data demonstrate that a physiological concentration of cortisol profoundly affects the functioning and perfusion of the human brain in vivo via a rapid, nongenomic mechanism. The changes in neuronal functioning suggest that cortisol acts on the thalamic relay of background as well as on task-specific sensory information, allowing focus and facilitation of adaptation to challenges.

Item URL in elib:https://elib.dlr.de/111661/
Document Type:Article
Title:Tune It Down to Live It Up? Rapid, Nongenomic Effects of Cortisol on the Human Brain
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Strelzyk, FlorianUNSPECIFIEDUNSPECIFIED
Hermes, Michaelmichael.hermes (at) dlr.deUNSPECIFIED
Naumann, EwaldUNSPECIFIEDUNSPECIFIED
Oitzl, MellyUNSPECIFIEDUNSPECIFIED
Walter, ChristophUNSPECIFIEDUNSPECIFIED
Busch, Hans-PeterUNSPECIFIEDUNSPECIFIED
Richter, SteffenUNSPECIFIEDUNSPECIFIED
Schächinger, HartmutUNSPECIFIEDUNSPECIFIED
Date:2012
Journal or Publication Title:Journal of Neuroscience
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:32
DOI :10.1523/JNEUROSCI.2384-11.2012
Page Range:pp. 616-624
Publisher:Society for Neuroscience
ISSN:0270-6474
ISBN:0270-6474
Status:Published
Keywords:Brain physiology, cortisol, stress hormones, neuronal activity, thalamus, arterial spin labeling, functional brain imaging
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:other
DLR - Research area:Raumfahrt
DLR - Program:R - no assignment
DLR - Research theme (Project):R - no assignment
Location: Hamburg
Institutes and Institutions:Institute of Aerospace Medicine > Aviation and Space Psychology
Deposited By: Hermes, Michael
Deposited On:17 Jul 2017 08:37
Last Modified:08 Mar 2018 18:40

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