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Rapid Adaptation to microgravity in mammalian macrophage cells

Thiel, Cora S. and Zélicourt, Diana de and Tauber, Svantje and Adrian, Astrid and Franz, Markus and Simmet, Dana M. and Schoppmann, Kathrin and Hauschild, Svantje and Krammer, Sonja and Christen, Miriam and Bradacs, Gesine and Paulsen, Katrin and Wolf, Susanne A. and Braun, Markus and Hatton, Jason and Kurtcuoglu, Vartan and Franke, Stefanie and Tanner, Samuel and Cristoforetti, Samantha and Sick, Beate and Hock, Bertold and Ullrich, Oliver (2017) Rapid Adaptation to microgravity in mammalian macrophage cells. Scientific Reports, 7 (43), pp. 1-13. Nature Publishing Group. DOI: 10.1038/s41598-017-00119-6 ISSN 2045-2322

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Official URL: http://www.nature.com/scientificreports


Despite the observed severe effects of microgravity on mammalian cells, many astronauts have completed long term stays in space without suffering from severe health problems. This raises questions about the cellular capacity for adaptation to a new gravitational environment. The International Space Station (ISS) experiment TRIPLE LUX A, performed in the BIOLAB laboratory of the ISS COLUMBUS module, allowed for the first time the direct measurement of a cellular function in real time and on orbit. We measured the oxidative burst reaction in mammalian macrophages (NR8383 rat alveolar macrophages) exposed to a centrifuge regime of internal 0 g and 1 g controls and step-wise increase or decrease of the gravitational force in four independent experiments. Surprisingly, we found that these macrophages adapted to microgravity in an ultra-fast manner within seconds, after an immediate inhibitory effect on the oxidative burst reaction. For the first time, we provided direct evidence of cellular sensitivity to gravity, through real-time on orbit measurements and by using an experimental system, in which all factors except gravity were constant. The surprisingly ultra-fast adaptation to microgravity indicates that mammalian macrophages are equipped with a highly efficient adaptation potential to a low gravity environment. This opens new avenues for the exploration of adaptation of mammalian cells to gravitational changes.

Item URL in elib:https://elib.dlr.de/111303/
Document Type:Article
Title:Rapid Adaptation to microgravity in mammalian macrophage cells
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Thiel, Cora S.University of Zürich, Universität Magdeburg, NASA-KFCUNSPECIFIED
Zélicourt, Diana deUniversity of ZürichUNSPECIFIED
Tauber, SvantjeUniversity of Zürich, Universität Magdeburg, NASA-KFCUNSPECIFIED
Adrian, AstridAirbus FriedrichshafenUNSPECIFIED
Franz, MarkusAirbus FriedrichshafenUNSPECIFIED
Simmet, Dana M.University of Zürich, Universität MagdeburgUNSPECIFIED
Schoppmann, KathrinUniversity of ZürichUNSPECIFIED
Hauschild, SvantjeUniversity of Zürich, Universität Magdeburg, NASA-KFCUNSPECIFIED
Krammer, SonjaUniversity of ZürichUNSPECIFIED
Christen, MiriamUniversity of ZürichUNSPECIFIED
Bradacs, GesineUniversity of ZürichUNSPECIFIED
Paulsen, KatrinUniversity of ZürichUNSPECIFIED
Wolf, Susanne A.University of ZürichUNSPECIFIED
Kurtcuoglu, VartanUniversity of ZürichUNSPECIFIED
Franke, StefanieDLR KölnUNSPECIFIED
Cristoforetti, SamanthaESA/ESTEC NoordwijkUNSPECIFIED
Sick, BeateUniversity of ZürichUNSPECIFIED
Hock, BertoldTU MünchenUNSPECIFIED
Ullrich, OliverUniversity of Zürich, Universität Magdeburg, NASA-KFC,UNSPECIFIED
Date:27 February 2017
Journal or Publication Title:Scientific Reports
Refereed publication:Yes
Open Access:Yes
Gold Open Access:Yes
In ISI Web of Science:Yes
DOI :10.1038/s41598-017-00119-6
Page Range:pp. 1-13
Publisher:Nature Publishing Group
Keywords:Adaptation, Microgravity
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Projekt USOC
Location: Bonn-Oberkassel , Köln-Porz
Institutes and Institutions:Space Administration
Space Operations and Astronaut Training > User center for space experiments (MUSC)
Deposited By: Herrmann, Astrid
Deposited On:13 Mar 2017 14:52
Last Modified:08 Mar 2018 18:36

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