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Using the Hephaistos orthotic device to study countermeasure effectiveness of neuromuscular electrical stimulation and dietary lupin protein supplementation, a randomised controlled trial

Zange, Jochen and Schopen, Katrin and Albracht, Kirsten and Gerlach, Darius A. and Frings-Meuthen, Petra and Maffiuletti, Nicola A. and Bloch, Wilhelm and Rittweger, Jörn (2017) Using the Hephaistos orthotic device to study countermeasure effectiveness of neuromuscular electrical stimulation and dietary lupin protein supplementation, a randomised controlled trial. PLoS One, 12 (2), e0171562. Public Library of Science (PLoS). DOI: 10.1371/journal.pone.0171562 ISSN 1932-6203

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Abstract

Purpose The present study investigated whether neuromuscular electrical stimulation for 20 min twice a day with an electrode placed over the soleus muscle and nutritional supplementation with 19 g of protein rich lupin seeds can reduce the loss in volume and strength of the human calf musculature during long term unloading by wearing an orthotic unloading device. Methods Thirteen healthy male subjects (age of 26.4 ± 3.7 years) wore a Hephaistos orthosis one leg for 60 days during all habitual activities. The leg side was randomly chosen for every subject. Six subjects only wore the orthosis as control group, and 7 subjects additionally received the countermeasure consisting of neuromuscular electrical stimulation of the soleus and lateral gastrocnemius muscles and lupin protein supplementation. Twenty-eight days before and on the penultimate day of the intervention cross-sectional images of the calf muscles were taken by magnetic resonance imaging (controls n = 5), and maximum voluntary torque (controls n = 6) of foot plantar flexion was estimated under isometric (extended knee, 90Ê knee flexion) and isokinetic conditions (extended knee), respectively. Results After 58 days of wearing the orthosis the percentage loss of volume in the entire triceps surae muscle of the control subjects (-11.9 ± 4.4%, mean ± standard deviation) was reduced by the countermeasure (-3.5 ± 7.2%, p = 0.032). Wearing the orthosis generally reduced plantar flexion torques values, however, only when testing isometric contraction at 90Ê knee ankle the countermeasure effected a significantly lower percentage decrease of torque (-9.7 ± 7.2%, mean ± SD) in comparison with controls (-22.3 ± 11.2%, p = 0.032). Conclusion Unloading of calf musculature by an orthotic device resulted in the expected loss of muscle volume and maximum of plantar flexion torque. Neuromuscular electrical muscle stimulation and lupin protein supplementation could significantly reduce the process of atrophy.

Item URL in elib:https://elib.dlr.de/111204/
Document Type:Article
Title:Using the Hephaistos orthotic device to study countermeasure effectiveness of neuromuscular electrical stimulation and dietary lupin protein supplementation, a randomised controlled trial
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Zange, JochenDLRhttps://orcid.org/0000-0003-1822-0952
Schopen, KatrinDLRUNSPECIFIED
Albracht, KirstenGerman Sport University Colognehttps://orcid.org/0000-0002-4271-2511
Gerlach, Darius A.DLRhttps://orcid.org/0000-0001-7044-6065
Frings-Meuthen, PetraDLRUNSPECIFIED
Maffiuletti, Nicola A.Schulthess Clinic, Zürich, CHhttps://orcid.org/0000-0001-5670-286X
Bloch, WilhelmGerman Sport University Colognehttps://orcid.org/0000-0003-1786-8853
Rittweger, JörnDLRhttps://orcid.org/0000-0002-2223-8963
Date:16 February 2017
Journal or Publication Title:PLoS One
Refereed publication:Yes
Open Access:Yes
Gold Open Access:Yes
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:12
DOI :10.1371/journal.pone.0171562
Page Range:e0171562
Publisher:Public Library of Science (PLoS)
ISSN:1932-6203
Status:Published
Keywords:Orthese, Muskelentlastung, Muskelabbau, Kraftverlust
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Systemphysiologie
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Space Physiology
Deposited By: Zange, Dr.rer.nat. Jochen
Deposited On:23 Feb 2017 12:10
Last Modified:08 Mar 2018 18:49

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