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Towards human exploration of space: the THESEUS review series on muscle and bone research priorities

Lang, Thomas and van Loon, Jack and Bloomfield, Susan and Vico, Laurence and Chopard, Angele and Rittweger, Jörn and Kyparos, Antonios and Blottner, Dieter and Vuori, Ilkka and Gerzer, Rupert and Cavanagh, Peter R. (2017) Towards human exploration of space: the THESEUS review series on muscle and bone research priorities. npj Microgravity, 3 (8), pp. 1-10. Nature Publishing Group. DOI: 10.1038/s41526-017-0013-0 ISSN 2373-8065

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Abstract

Without effective countermeasures, the musculoskeletal system is altered by the microgravity environment of long-duration spaceflight, resulting in atrophy of bone and muscle tissue, as well as in deficits in the function of cartilage, tendons, and vertebral disks. While inflight countermeasures implemented on the International Space Station have evidenced reduction of bone and muscle loss on low-Earth orbit missions of several months in length, important knowledge gaps must be addressed in order to develop effective strategies for managing human musculoskeletal health on exploration class missions well beyond Earth orbit. Analog environments, such as bed rest and/or isolation environments, may be employed in conjunction with large sample sizes to understand sex differences in countermeasure effectiveness, as well as interaction of exercise with pharmacologic, nutritional, immune system, sleep and psychological countermeasures. Studies of musculoskeletal biomechanics, involving both human subject and computer simulation studies, are essential to developing strategies to avoid bone fractures or other injuries to connective tissue during exercise and extravehicular activities. Animal models may be employed to understand effects of the space environment that cannot be modeled using human analog studies. These include studies of radiation effects on bone and muscle, unraveling the effects of genetics on bone and muscle loss, and characterizing the process of fracture healing in the mechanically unloaded and immuno-compromised spaceflight environment. In addition to setting the stage for evidence-based management of musculoskeletal health in long-duration space missions, the body of knowledge acquired in the process of addressing this array of scientific problems will lend insight into the understanding of terrestrial health conditions such as age-related osteoporosis and sarcopenia.

Item URL in elib:https://elib.dlr.de/111162/
Document Type:Article
Title:Towards human exploration of space: the THESEUS review series on muscle and bone research priorities
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Lang, ThomasUniversity of California, CA, San Francisco, USAUNSPECIFIED
van Loon, Jackdepartment of oral cell biology, desc, acta-free university, amsterdam, the netherlandsUNSPECIFIED
Bloomfield, SusanDepartment of Health & Kinesiology, Texas A&M University, College Station, TX,UNSPECIFIED
Vico, LaurenceUniversity of St. Etienne, St. Etienne, FranceUNSPECIFIED
Chopard, AngeleUniversity of Montpellier 1, Montpellier, FranceUNSPECIFIED
Rittweger, Jörninstitute of aerospace medicine, deutsches zentrum für luft- und raumfahrt, dlr e.v., cologne, germany and medical faculty, university of cologne, cologne, germany; joern.rittweger (at) dlr.deUNSPECIFIED
Kyparos, AntoniosAristotle University of ThessalonikiUNSPECIFIED
Blottner, Dietercharité - university medicine berlinUNSPECIFIED
Vuori, Ilkka9UKK Institute for Health Promotion Research, Tampere, FinlandUNSPECIFIED
Gerzer, RupertSkoltech University, Moscow, RussiaUNSPECIFIED
Cavanagh, Peter R.University of Washington MedicalUNSPECIFIED
Date:2017
Journal or Publication Title:npj Microgravity
Refereed publication:Yes
Open Access:Yes
Gold Open Access:Yes
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:3
DOI :10.1038/s41526-017-0013-0
Page Range:pp. 1-10
Publisher:Nature Publishing Group
ISSN:2373-8065
Status:Published
Keywords:muscle; bone; musculoskeletal; countermeasures
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Integrative Studien (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Space Physiology
Deposited By: Becker, Christine
Deposited On:23 Feb 2017 12:06
Last Modified:17 Nov 2018 05:02

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