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Meagre effects of disuse on the human fibula are not explained by bone size or geometry

Ireland, Alex and Capozza, R.F. and Nocciolino, L. M. and Rittweger, Jörn (2017) Meagre effects of disuse on the human fibula are not explained by bone size or geometry. Osteoporosis International, 28 (2), pp. 633-641. Springer. doi: 10.1007/s00198-016-3779-0. ISSN 0937-941X.

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Summary Fibula response to disuse is unknown; we assessed fibula bone in spinal cord injury (SCI) patients and able-bodied counterparts. Group differences were smaller than in the neighbouring tibia which could not be explained by bone geometry. Differential adaptation of the shank bones may indicate previously unknown mechanoadaptive behaviours of bone. Introduction The fibula supports only a small and highly variable proportion of shank compressive load (−8 to +19 %), and little is known about other kinds of stresses. Hence, whilst effects of habitual loading on tibia are well-known, fibula response to disuse is difficult to predict. Methods Therefore, we assessed fibular bone strength using peripheral quantitative computed tomography (pQCT) at 5 % increments from 5 to 90 % distal-proximal tibia length in nine participants with long-term spinal cord injury (SCI; age 39.2 ± 6.2 years, time since injury 17.8 ± 7.4 years), representing a cross-sectional model of long-term disuse and in nine able-bodied counterparts of similar age (39.6 ± 7.8 years), height and mass. Results There was no group difference in diaphyseal fibula total bone mineral content (BMC) (P = 0.22, 95 % CIs -7.4 % to -13.4 % and +10.9 % to +19.2 %). Site by group interactions (P < 0.001) revealed 27 and 22 % lower BMC in SCI at 5 and 90 % (epiphyseal) sites only. Cortical bone geometry differed at mid and distal diaphysis, with lower endocortical circumference and greater cortical thickness in SCI than able-bodied participants in this region only (interactions both P < 0.01). Tibia bone strength was also assessed; bone by group interactions showed smaller group differences in fibula than tibia for all bone parameters, with opposing effects on distal diaphysis geometry in the two bones (all Ps < 0.001). Conclusions These results suggest that the structure of the fibula diaphysis is not heavily influenced by compressive loading, and only mid and distal diaphysis are influenced by bending and/or torsional loads. The fibula is less influenced by disuse than the tibia, which cannot satisfactorily be explained by differences in bone geometry or relative changes in habitual loading in disuse. Biomechanical study of the shank loading environment may give new information pertaining to factors influencing bone mechanoadaptation.

Item URL in elib:https://elib.dlr.de/110989/
Document Type:Article
Title:Meagre effects of disuse on the human fibula are not explained by bone size or geometry
AuthorsInstitution or Email of AuthorsAuthor's ORCID iD
Ireland, Alexmanchester metropolitan universityUNSPECIFIED
Capozza, R.F.university of rosarioUNSPECIFIED
Nocciolino, L. M.cemfocUNSPECIFIED
Rittweger, Jörninstitute of aerospace medicine, deutsches zentrum für luft- und raumfahrt, dlr e.v., cologne, germany and medical faculty, university of cologne, cologne, germany; joern.rittweger (at) dlr.deUNSPECIFIED
Date:February 2017
Journal or Publication Title:Osteoporosis International
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In ISI Web of Science:Yes
DOI :10.1007/s00198-016-3779-0
Page Range:pp. 633-641
Keywords:Loading; Mechanoadaptation; pQCT
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - Vorhaben Integrative Studien (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Space Physiology
Deposited By: Becker, Christine
Deposited On:07 Feb 2017 10:59
Last Modified:06 Sep 2019 15:20

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