elib
DLR-Header
DLR-Logo -> http://www.dlr.de
DLR Portal Home | Impressum | Datenschutz | Kontakt | English
Schriftgröße: [-] Text [+]

Meagre effects of disuse on the human fibula are not explained by bone size or geometry

Ireland, Alex und Capozza, R.F. und Nocciolino, L. M. und Rittweger, Jörn (2017) Meagre effects of disuse on the human fibula are not explained by bone size or geometry. Osteoporosis International, 28 (2), Seiten 633-641. Springer. doi: 10.1007/s00198-016-3779-0. ISSN 0937-941X.

Dieses Archiv kann nicht den Volltext zur Verfügung stellen.

Kurzfassung

Summary Fibula response to disuse is unknown; we assessed fibula bone in spinal cord injury (SCI) patients and able-bodied counterparts. Group differences were smaller than in the neighbouring tibia which could not be explained by bone geometry. Differential adaptation of the shank bones may indicate previously unknown mechanoadaptive behaviours of bone. Introduction The fibula supports only a small and highly variable proportion of shank compressive load (−8 to +19 %), and little is known about other kinds of stresses. Hence, whilst effects of habitual loading on tibia are well-known, fibula response to disuse is difficult to predict. Methods Therefore, we assessed fibular bone strength using peripheral quantitative computed tomography (pQCT) at 5 % increments from 5 to 90 % distal-proximal tibia length in nine participants with long-term spinal cord injury (SCI; age 39.2 ± 6.2 years, time since injury 17.8 ± 7.4 years), representing a cross-sectional model of long-term disuse and in nine able-bodied counterparts of similar age (39.6 ± 7.8 years), height and mass. Results There was no group difference in diaphyseal fibula total bone mineral content (BMC) (P = 0.22, 95 % CIs -7.4 % to -13.4 % and +10.9 % to +19.2 %). Site by group interactions (P < 0.001) revealed 27 and 22 % lower BMC in SCI at 5 and 90 % (epiphyseal) sites only. Cortical bone geometry differed at mid and distal diaphysis, with lower endocortical circumference and greater cortical thickness in SCI than able-bodied participants in this region only (interactions both P < 0.01). Tibia bone strength was also assessed; bone by group interactions showed smaller group differences in fibula than tibia for all bone parameters, with opposing effects on distal diaphysis geometry in the two bones (all Ps < 0.001). Conclusions These results suggest that the structure of the fibula diaphysis is not heavily influenced by compressive loading, and only mid and distal diaphysis are influenced by bending and/or torsional loads. The fibula is less influenced by disuse than the tibia, which cannot satisfactorily be explained by differences in bone geometry or relative changes in habitual loading in disuse. Biomechanical study of the shank loading environment may give new information pertaining to factors influencing bone mechanoadaptation.

elib-URL des Eintrags:https://elib.dlr.de/110989/
Dokumentart:Zeitschriftenbeitrag
Titel:Meagre effects of disuse on the human fibula are not explained by bone size or geometry
Autoren:
AutorenInstitution oder E-Mail-AdresseAutoren-ORCID-iDORCID Put Code
Ireland, Alexmanchester metropolitan universityNICHT SPEZIFIZIERTNICHT SPEZIFIZIERT
Capozza, R.F.university of rosarioNICHT SPEZIFIZIERTNICHT SPEZIFIZIERT
Nocciolino, L. M.cemfocNICHT SPEZIFIZIERTNICHT SPEZIFIZIERT
Rittweger, Jörninstitute of aerospace medicine, deutsches zentrum für luft- und raumfahrt, dlr e.v., cologne, germany and medical faculty, university of cologne, cologne, germany; joern.rittweger (at) dlr.deNICHT SPEZIFIZIERTNICHT SPEZIFIZIERT
Datum:Februar 2017
Erschienen in:Osteoporosis International
Referierte Publikation:Ja
Open Access:Nein
Gold Open Access:Nein
In SCOPUS:Ja
In ISI Web of Science:Ja
Band:28
DOI:10.1007/s00198-016-3779-0
Seitenbereich:Seiten 633-641
Verlag:Springer
ISSN:0937-941X
Status:veröffentlicht
Stichwörter:Loading; Mechanoadaptation; pQCT
HGF - Forschungsbereich:Luftfahrt, Raumfahrt und Verkehr
HGF - Programm:Raumfahrt
HGF - Programmthema:Forschung unter Weltraumbedingungen
DLR - Schwerpunkt:Raumfahrt
DLR - Forschungsgebiet:R FR - Forschung unter Weltraumbedingungen
DLR - Teilgebiet (Projekt, Vorhaben):R - Vorhaben Integrative Studien (alt)
Standort: Köln-Porz
Institute & Einrichtungen:Institut für Luft- und Raumfahrtmedizin > Weltraumphysiologie
Hinterlegt von: Becker, Christine
Hinterlegt am:07 Feb 2017 10:59
Letzte Änderung:06 Sep 2019 15:20

Nur für Mitarbeiter des Archivs: Kontrollseite des Eintrags

Blättern
Suchen
Hilfe & Kontakt
Informationen
electronic library verwendet EPrints 3.3.12
Gestaltung Webseite und Datenbank: Copyright © Deutsches Zentrum für Luft- und Raumfahrt (DLR). Alle Rechte vorbehalten.