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DNA DAMAGE RESPONSE OF EX-VIVO PORCINE EYE LENSES IN ORGAN-CULTURE AND IN-VITRO CULTURED LENS EPITHELIAL CELLS TO IONIZING RADIATION.

Baumstark-Khan, Christa and Konda, Bikash and Spitta, Luis and Hellweg, Christine (2016) DNA DAMAGE RESPONSE OF EX-VIVO PORCINE EYE LENSES IN ORGAN-CULTURE AND IN-VITRO CULTURED LENS EPITHELIAL CELLS TO IONIZING RADIATION. 41st Scientific Assembly of the Committee on Space Research (COSPAR), 30. Juli - 7. August 2016, Istanbul, Turkey.

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Abstract

Astronauts on space missions, especially on long-term missions to Moon or Mars have a higher risk for the expression of radiation late effects such as cancer or sub-capsular cortical eye lens opacities. This is due to higher dose and different patterns of cellular energy deposition from high-linear-energy-transfer (LET) components of galactic cosmic radiation in space than that of terrestrial low-LET radiation on Earth. The eye lens is considered to be a radiation sensitive organ with radiation induced cataract to occur with a threshold absorbed dose of 0.5 Gy of sparsely ionizing radiation. For terrestrial occupational radiation lens exposure limit is set to yearly 20 mSv by the International Commission on Radiological Protection (1). Doses perceived by astronauts are much higher: in average 150 mSv per year on the International Space Station (ISS) and 1.2 to 1.4 mSv per day on Apollo and Skylab missions (2).

Item URL in elib:https://elib.dlr.de/109922/
Document Type:Conference or Workshop Item (Speech)
Title:DNA DAMAGE RESPONSE OF EX-VIVO PORCINE EYE LENSES IN ORGAN-CULTURE AND IN-VITRO CULTURED LENS EPITHELIAL CELLS TO IONIZING RADIATION.
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Baumstark-Khan, Christachrista.baumstark-khan (at) dlr.deUNSPECIFIED
Konda, Bikashbikash.konda (at) dlr.deUNSPECIFIED
Spitta, Luisluis.spitta (at) dlr.deUNSPECIFIED
Hellweg, Christinechristine.hellweg (at) dlr.deUNSPECIFIED
Date:2016
Refereed publication:Yes
Open Access:Yes
Gold Open Access:No
In SCOPUS:No
In ISI Web of Science:No
Status:Published
Keywords:DNA damage, Ionizing Radiation, IN-VITRO CULTURED LENS EPITHELIAL CELLS
Event Title:41st Scientific Assembly of the Committee on Space Research (COSPAR)
Event Location:Istanbul, Turkey
Event Type:international Conference
Event Dates:30. Juli - 7. August 2016
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Strahlenbiologie
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Radiation Biology
Deposited By: Kopp, Kerstin
Deposited On:04 Jan 2017 16:03
Last Modified:31 Jul 2019 20:07

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