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Global sensitivity analysis of a model for venous valve dynamics

Keijsers, J.M.T. and Leguy, C.A.D. and Huberts, W. and Narracott, A.J. and Rittweger, J. and van de Vosse, F.N. (2016) Global sensitivity analysis of a model for venous valve dynamics. Journal of Biomechanics, 49 (13), pp. 2845-2853. Elsevier. doi: 10.1016/j.jbiomech.2016.06.029. ISSN 0021-9290.

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Chronic venous disease is defined as dysfunction of the venous system caused by incompetent venous valves with or without a proximal venous obstruction. Assessing the severity of the disease is challenging, since venous function is determined by various interacting hemodynamic factors. Mathematical models can relate these factors using physical laws and can thereby aid understanding of venous (patho-)physiology. To eventually use a mathematical model to support clinical decision making, first the model sensitivity needs to be determined. Therefore, the aim of this study is to assess the sensitivity of the venous valve model outputs to the relevant input parameters. Using a 1D pulse wave propagation model of the tibial vein including a venous valve, valve dynamics under head up tilt are simulated. A variance-based sensitivity analysis is performed based on generalized polynomial chaos expansion. Taking a global approach, individual parameter importance on the valve dynamics as well as importance of their interactions is determined. For the output related to opening state of the valve, the opening/closing pressure drop (dpvalve,0) is found to be the most important parameter. The venous radius (rvein,0) is related to venous filling volume and is consequently most important for the output describing venous filling time. Finally, it is concluded that improved assessment of rvein,0 and dpvalve,0 is most rewarding when simulating valve dynamics, as this results in the largest reduction in output uncertainty. In practice, this could be achieved using ultrasound imaging of the veins and fluid structure interaction simulations to characterize detailed valve dynamics, respectively.

Item URL in elib:https://elib.dlr.de/109137/
Document Type:Article
Title:Global sensitivity analysis of a model for venous valve dynamics
AuthorsInstitution or Email of AuthorsAuthor's ORCID iD
Keijsers, J.M.T.institute of aerospace medicine, german aerospace centerUNSPECIFIED
Leguy, C.A.D.institute of aerospace medicine, german aerospace centerUNSPECIFIED
Huberts, W.department of biomedical engineering, eindhoven university of technologyUNSPECIFIED
Narracott, A.J.medical physics group, department of cardiovascular science, university of sheffieldUNSPECIFIED
Rittweger, J.institute of aerospace medicine, deutsches zentrum für luft- und raumfahrt, dlr e.v., cologne, germany and medical faculty, university of cologne, cologne, germany; joern.rittweger (at) dlr.deUNSPECIFIED
van de Vosse, F.N.department of biomedical engineering, eindhoven university of technology,UNSPECIFIED
Date:6 September 2016
Journal or Publication Title:Journal of Biomechanics
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In ISI Web of Science:Yes
DOI :10.1016/j.jbiomech.2016.06.029
Page Range:pp. 2845-2853
EditorsEmailEditor's ORCID iD
Guilak, FarshidWashington University and St. Louis Shriners Hospital, St. Louis, MO, USAUNSPECIFIED
Keywords:Chronic venous disease; Generalized polynomial chaos expansion; Sensitivity analysis; Venous valves; Versatile valve model
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - Vorhaben Integrative Studien (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Space Physiology
Deposited By: Becker, Christine
Deposited On:15 Dec 2016 17:25
Last Modified:06 Sep 2019 15:19

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