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Whey protein with potassium bicarbonate supplement attenuates the reduction in muscle oxidative capacity during 19 days bed rest

Bosutti, Alessandra and Salanova, Michele and Blottner, Dieter and Bühlmeier, Judith and Mulder, Edwin and Rittweger, Jörn and Yap, MH and Ganse, Bergita and Degens, Hans (2016) Whey protein with potassium bicarbonate supplement attenuates the reduction in muscle oxidative capacity during 19 days bed rest. Journal of Applied Physiology, 121 (4), pp. 838-848. American Physiological Society. DOI: 10.1152/japplphysiol.00936.2015 ISSN 8750-7587

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Abstract

The effectiveness of whey protein plus potassium bicarbonate-enriched diet (WP+KHCO3) in mitigating disuse-induced changes in muscle fiber oxidative capacity and capillarization was investigated in a 21-day crossover design bed rest study. Ten healthy men (31 ± 6 yr) once received WP+KHCO3 and once received a standardized isocaloric diet. Muscle biopsies were taken 2 days before and during the 19th day of bed rest (BR) from the soleus (SOL) and vastus lateralis (VL) muscle. Whole-body aerobic power (V̇o2 max), muscle fatigue, and isometric strength of knee extensor and plantar flexor muscles were monitored. Muscle fiber types and capillaries were identified by immunohistochemistry. Fiber oxidative capacity was determined as the optical density (OD) at 660 nm of succinate dehydrogenase (SDH)-stained sections. The product of fiber cross-sectional area and SDH-OD (integrated SDH) indicated the maximal oxygen consumption of that fiber. The maximal oxygen consumption supported by a capillary was calculated as the integrated SDH in its supply area. BR reduced isometric strength of knee extensor muscles (P < 0.05), and the fiber oxidative capacity (P < 0.001) and V̇o2 max (P = 0.042), but had no significant impact on muscle capillarization or fatigue resistance of thigh muscles. The maximal oxygen consumption supported by a capillary was reduced by 24% in SOL and 16% in VL (P < 0.001). WP+KHCO3 attenuated the disuse-induced reduction in fiber oxidative capacity in both muscles (P < 0.01). In conclusion, following 19 days of bed rest, the decrement in fiber oxidative capacity is proportionally larger than the loss of capillaries. WP+KHCO3 appears to attenuate disuse-induced reductions in fiber oxidative capacity.

Item URL in elib:https://elib.dlr.de/109134/
Document Type:Article
Title:Whey protein with potassium bicarbonate supplement attenuates the reduction in muscle oxidative capacity during 19 days bed rest
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Bosutti, Alessandradepartment of clinical, technological and morphological sciences, division of internal medicine, university triest, italienUNSPECIFIED
Salanova, Michelecharité - university medicine berlinUNSPECIFIED
Blottner, Dietercharité - university medicine berlinUNSPECIFIED
Bühlmeier, Judithuniversity of bonn, germanyUNSPECIFIED
Mulder, Edwingerman aerospace center (dlr), institute of aerospace medicine, space physiology, cologne, germanyUNSPECIFIED
Rittweger, Jörninstitute of aerospace medicine, deutsches zentrum für luft- und raumfahrt, dlr e.v., cologne, germany and medical faculty, university of cologne, cologne, germany; joern.rittweger (at) dlr.deUNSPECIFIED
Yap, MHSchool of Healthcare Science, Manchester Metropolitan University, Manchester, United KingdomUNSPECIFIED
Ganse, Bergitadivision space physiology, institute of aerospace medicine, german aerospace center, cologne, bergita.ganse (at) dlr.deUNSPECIFIED
Degens, Hansmanchester metropolitan universityUNSPECIFIED
Date:1 October 2016
Journal or Publication Title:Journal of Applied Physiology
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:121
DOI :10.1152/japplphysiol.00936.2015
Page Range:pp. 838-848
Publisher:American Physiological Society
ISSN:8750-7587
Status:Published
Keywords:bed rest; capillarization; microgravity; muscle atrophy; oxidative capacity; whey protein
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Integrative Studien (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Space Physiology
Deposited By: Becker, Christine
Deposited On:15 Dec 2016 17:17
Last Modified:06 Sep 2019 15:27

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