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Circadian variation of metabotropic glutamate receptor 5 availability in the rat brain

Elmenhorst, D. and Mertens, K. and Kroll, T. and Oskamp, A. and Ermert, J. and Elmenhorst, Eva-Maria and Wedekind, F. and Beer, S. and Coenen, H.H. and Bauer, A. (2016) Circadian variation of metabotropic glutamate receptor 5 availability in the rat brain. Journal of Sleep Research. Wiley. DOI: doi: 10.1111/jsr.12432 ISSN 0962-1105 (In Press)

Full text not available from this repository.

Official URL: https://www.ncbi.nlm.nih.gov/pubmed/27357735

Abstract

The metabotropic subtype 5 glutamate receptor (mGluR5) plays a critical role in synaptic plasticity besides its involvement in numerous neurological disorders like depression. As mGluR5 availability in humans is altered in sleep deprivation we hypothesized that mGluR5 availability underlies a circadian variation. To investigate whether mGluR5 underlies potential circadian changes we measured its density in a randomized fashion at 6 different daytimes in 11 adult Sprague Dawley rats. mGluR5 density was quantified by positron emission tomography (PET) using the radioactive ligand [11C]ABP688. [11C]ABP688 uptake was quantified in nine regions of interest with a reference tissue model. Significant differences in the binding potential (BPND) and therefore mGluR5 availability between the different circadian times were found in cortex, cingulate cortex, amygdala, caudate putamen and nucleus accumbens. Further post hoc statistical analysis (Tukey-Kramer test) of the different time points revealed significant changes in BPND between 7am (start of light-on phase) and 3pm (last time point of the light-on phase) in the caudate putamen. This study shows that mGluR5 availability is increased during the light-on or sleep phase of rodents by about 10%. Given that altered mGluR5 densities play a role in psychiatric disorders further investigation are warranted to evaluate their circadian involvement in mood changes in humans.

Item URL in elib:https://elib.dlr.de/108453/
Document Type:Article
Title:Circadian variation of metabotropic glutamate receptor 5 availability in the rat brain
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Elmenhorst, D.UNSPECIFIEDUNSPECIFIED
Mertens, K.UNSPECIFIEDUNSPECIFIED
Kroll, T.UNSPECIFIEDUNSPECIFIED
Oskamp, A.UNSPECIFIEDUNSPECIFIED
Ermert, J.UNSPECIFIEDUNSPECIFIED
Elmenhorst, Eva-Mariaeva-maria.elmenhorst (at) dlr.dehttps://orcid.org/0000-0003-0336-6705
Wedekind, F.UNSPECIFIEDUNSPECIFIED
Beer, S.UNSPECIFIEDUNSPECIFIED
Coenen, H.H.UNSPECIFIEDUNSPECIFIED
Bauer, A.UNSPECIFIEDUNSPECIFIED
Date:2016
Journal or Publication Title:Journal of Sleep Research
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In SCOPUS:Yes
In ISI Web of Science:Yes
DOI :doi: 10.1111/jsr.12432
Publisher:Wiley
ISSN:0962-1105
Status:In Press
Keywords:Positron emission tomography; rat; circadian rhythm; metabotropic glutamate receptor; [11C]ABP688
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Aeronautics
HGF - Program Themes:air traffic management and operations
DLR - Research area:Aeronautics
DLR - Program:L AO - Air Traffic Management and Operation
DLR - Research theme (Project):L - Human factors and safety in Aeronautics
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Flight Physiology
Deposited By: Sender, Alina
Deposited On:29 Nov 2016 10:23
Last Modified:06 Sep 2019 15:19

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