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Interindividual variabilities in cognitive performance degradation after alcohol consuption and sleep loss are related

Elmenhorst, Eva-Maria and Benderoth, S. and Vejvoda, M. and Wenzel, J. and Aeschbach, D. (2016) Interindividual variabilities in cognitive performance degradation after alcohol consuption and sleep loss are related. International Symposium on Somnolence, Vigilance and Safety, 22.-23.02.2016, Brüssel. (Unpublished)

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Abstract

Introduction The sleep inducing effects of alcohol as well as the increase in sleep propensity and sleepiness after sleep loss have been linked to the adenosinergic system in the brain. While the performance impairing effects of ethanol have partly been related to the inhibitory effects of cerebral adenosine, sleep loss has been found to increase adenosine receptor density. The interindividual variability of cognitive performance impairments after alcohol intake as well as after sleep loss is extensive. Thus, we examined in humans whether performance degradations resulting from sleep loss and alcohol consumption are related. Methods Performance in a 10-min Psychomotor Vigilance Task (PVT) was tested in 47 healthy volunteers (mean age 27 ± 5 (SD) years, 21 females) at 6 pm 1) after an 8 hour control night, 2) after alcohol consumption (aiming at a blood alcohol concentration (BAC) of 0.08%), and 3) after 35 hours of total sleep deprivation. After alcohol intake, 35 of the participants reached a BAC of more than 0.06% prior to the performance testing (mean BAC 0.074%, SD 0.009%, min. 0.063%, max. 0.095%) and were included in the analyses. Two recovery nights were scheduled between conditions. Results Performance impairments due to acute alcohol intake and due to 35 hours of sustained wakefulness were calculated as differences from performance under control conditions. The degree in performance degradation correlated highly between both conditions (i.e. 10% slowest reaction times: Pearson’s r=0.73, p<0.0001; standard deviation of reaction times: r=0.75, p<0.0001; mean reaction time: r=0.59, p=0.0002). Conclusions Participants whose PVT performance proved to be vulnerable to the effects of alcohol consumption were also vulnerable to sleep loss, whereas individuals who were resilient against the effects of alcohol were also less susceptible to the impact of sleep deprivation. These results suggest that the effects of alcohol and sleep deprivation on performance are mediated – at least in part – by a common pathway that may involve the adenosinergic system in the brain.

Item URL in elib:https://elib.dlr.de/108435/
Document Type:Conference or Workshop Item (Speech)
Title:Interindividual variabilities in cognitive performance degradation after alcohol consuption and sleep loss are related
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Elmenhorst, Eva-Mariaeva-maria.elmenhorst (at) dlr.dehttps://orcid.org/0000-0003-0336-6705
Benderoth, S.sibylle.benderoth (at) dlr.deUNSPECIFIED
Vejvoda, M.martin.vejvoda (at) dlr.deUNSPECIFIED
Wenzel, J.juergen.wenzel (at) dlr.deUNSPECIFIED
Aeschbach, D.daniel.aeschbach (at) dlr.deUNSPECIFIED
Date:2016
Refereed publication:Yes
Open Access:Yes
Gold Open Access:No
In SCOPUS:No
In ISI Web of Science:No
Status:Unpublished
Keywords:sleep deprivation, performance, PVT, inter-individual differences, ethanol, adenosine
Event Title:International Symposium on Somnolence, Vigilance and Safety
Event Location:Brüssel
Event Type:international Conference
Event Dates:22.-23.02.2016
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Aeronautics
HGF - Program Themes:air traffic management and operations
DLR - Research area:Aeronautics
DLR - Program:L AO - Air Traffic Management and Operation
DLR - Research theme (Project):L - Human factors and safety in Aeronautics, V - no assignment
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Flight Physiology
Deposited By: Sender, Alina
Deposited On:29 Nov 2016 12:01
Last Modified:31 Jul 2019 20:05

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