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Recent Topics in Gravitational Biology Research at the DLR Institute of Aerospace Medicine

Brungs, Sonja and Liemersdorf, Christian and Acharya, Aviseka and Witke, Walter and Hescheler, Jürgen and Sachinidis, Apapios and Hemmersbach, Ruth (2016) Recent Topics in Gravitational Biology Research at the DLR Institute of Aerospace Medicine. 32. Annual Meeting Conference of the American Society for Gravitational and Space Research (ASGSR) 2016, 25. – 29. Okt. 2016, Cleveland, USA.

Full text not available from this repository.

Abstract

Ground-based facilities (GBFs) such as clinostats, Random Positioning Machines, centrifuges and others were utilized by European researchers during the ESA Ground-based Facility Program and projects and results were recently published. Here, we provide examples for the use of and experiences gained with GBFs at the Institute of Aerospace Medicine (DLR), department of Gravitational Biology. We discuss differences and limitations of various facilities in comparison to each other in respect to their ability to provide altered gravity from the view of the biosystem employed. Our results support the necessity of a ground-based program, which at low cost - in comparison to space flight - provides the opportunity to intensively prepare experiments for space. Finally, ground-based data should ideally be validated in real microgravity, which we performed to some extent using the drop tower in Bremen, parabolic flights and sounding rockets. Furthermore, we give an overview of our current research topics such as mouse neuronal development in hypergravity as well as mouse embryonic stem cell differentiation, demonstrating a distinct influence of (altered) gravity on the underlying mechanisms.

Item URL in elib:https://elib.dlr.de/108389/
Document Type:Conference or Workshop Item (Speech)
Title:Recent Topics in Gravitational Biology Research at the DLR Institute of Aerospace Medicine
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Brungs, Sonjagerman aerospace centre (dlr), institute of aerospace medicine, gravitational biology, cologne, germanyUNSPECIFIED
Liemersdorf, Christiangerman aerospace centre (dlr), institute of aerospace medicine, gravitational biology, cologne, germanyUNSPECIFIED
Acharya, AvisekaUniversity of Cologne, Institute of Neurophysiology, Center of Physiology and Pathophysiology, Cologne, GermanyUNSPECIFIED
Witke, WalterUniversity of Bonn, Institute of Genetics, Bonn, GermanyUNSPECIFIED
Hescheler, Jürgenuniversity of cologne, institute of neurophysiology and center for molecular medicine cologne (cmmc), cologne, germanyUNSPECIFIED
Sachinidis, Apapiosuniversity of cologne, institute of neurophysiology and center for molecular medicine cologne (cmmc), cologne, germanyUNSPECIFIED
Hemmersbach, Ruthgerman aerospace centre (dlr), institute of aerospace medicine, gravitational biology, cologne, germanyUNSPECIFIED
Date:25 October 2016
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In SCOPUS:No
In ISI Web of Science:No
Status:Published
Keywords:Microgravity, Hypergravity, Clinostat, Centrifuge, Random Positioning Machine, Stem Cells
Event Title:32. Annual Meeting Conference of the American Society for Gravitational and Space Research (ASGSR) 2016
Event Location:Cleveland, USA
Event Type:international Conference
Event Dates:25. – 29. Okt. 2016
Organizer:ASGBR
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Biowissenschaftliche Exp.-vorbereitung, R - Vorhaben Biowissenschaftliche Nutzerunterstützung
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Biomedical Research
Deposited By: Duwe, Helmut
Deposited On:29 Nov 2016 10:31
Last Modified:29 Nov 2016 10:31

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