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Circadien gene variants influence sleep and the sleep electroencephalogram in humans

Chang, A.-M. and Bjonnes, A.C. and Aeschbach, D. and Buxton, O.M. and Gooley, J.J. and Anderson, C. and Van Reen, E. and Cain, S.W. and Czeisler, C.A. and Duffy, J. F. and Lockley, S.W. and Shea, S.A. and Scheer, F.A.J.L. and Saxena, R. (2016) Circadien gene variants influence sleep and the sleep electroencephalogram in humans. Chronobiology International, 33 (5), pp. 561-573. Taylor & Francis. DOI: 10.3109/07420528.2016.1167078 ISSN 0742-0528

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Abstract

The sleep electroencephalogram (EEG) is highly heritable in humans and yet little is known about the genetic basis of inter-individual differences in sleep architecture. The aim of this study was to identify associations between candidate circadian gene variants and the polysomnogram, recorded under highly controlled laboratory conditions during a baseline, overnight, 8 h sleep opportunity. A candidate gene approach was employed to analyze single-nucleotide polymorphisms from five circadian-related genes in a two-phase analysis of 84 healthy young adults (28 F; 23.21 ± 2.97 years) of European ancestry. A common variant in Period2 (PER2) was associated with 20 min less slow-wave sleep (SWS) in carriers of the minor allele than in noncarriers, representing a 22% reduction in SWS duration. Moreover, spectral analysis in a subset of participants (n = 37) showed the same PER2 polymorphism was associated with reduced EEG power density in the low delta range (0.25–1.0 Hz) during non-REM sleep and lower slow-wave activity (0.75–4.5 Hz) in the early part of the sleep episode. These results indicate the involvement of PER2 in the homeostatic process of sleep. Additionally, a rare variant in Melatonin Receptor 1B was associated with longer REM sleep latency, with minor allele carriers exhibiting an average of 65 min (87%) longer latency from sleep onset to REM sleep, compared to noncarriers. These findings suggest that circadianrelated genes can modulate sleep architecture and the sleep EEG, including specific parameters previously implicated in the homeostatic regulation of sleep.

Item URL in elib:https://elib.dlr.de/108371/
Document Type:Article
Title:Circadien gene variants influence sleep and the sleep electroencephalogram in humans
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Chang, A.-M.UNSPECIFIEDUNSPECIFIED
Bjonnes, A.C.UNSPECIFIEDUNSPECIFIED
Aeschbach, D.daniel.aeschbach (at) dlr.deUNSPECIFIED
Buxton, O.M.UNSPECIFIEDUNSPECIFIED
Gooley, J.J.UNSPECIFIEDUNSPECIFIED
Anderson, C.UNSPECIFIEDUNSPECIFIED
Van Reen, E.UNSPECIFIEDUNSPECIFIED
Cain, S.W.UNSPECIFIEDUNSPECIFIED
Czeisler, C.A.UNSPECIFIEDUNSPECIFIED
Duffy, J. F.UNSPECIFIEDUNSPECIFIED
Lockley, S.W.UNSPECIFIEDUNSPECIFIED
Shea, S.A.UNSPECIFIEDUNSPECIFIED
Scheer, F.A.J.L.UNSPECIFIEDUNSPECIFIED
Saxena, R.UNSPECIFIEDUNSPECIFIED
Date:2016
Journal or Publication Title:Chronobiology International
Refereed publication:Yes
Open Access:Yes
Gold Open Access:No
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:33
DOI :10.3109/07420528.2016.1167078
Page Range:pp. 561-573
Publisher:Taylor & Francis
ISSN:0742-0528
Status:Published
Keywords:Sleep, Circadian Genes, Electroencephalogram
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Aeronautics
HGF - Program Themes:air traffic management and operations
DLR - Research area:Aeronautics
DLR - Program:L AO - Air Traffic Management and Operation
DLR - Research theme (Project):L - Human factors and safety in Aeronautics
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Flight Physiology
Deposited By: Sender, Alina
Deposited On:29 Nov 2016 09:40
Last Modified:06 Sep 2019 15:16

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