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On the combined effects of normobaric hypoxia and bed rest upon bone and mineral metabolism: Results from the PlanHab study

Rittweger, J. and Debevec, T. and Frings-Meuthen, P. and Lau, P. and Mittag, U. and Ganse, B. and Ferstl, P.G. and Simpson, E.J. and Macdonald, I.A. and Eiken, O and Mekjavic, I. (2016) On the combined effects of normobaric hypoxia and bed rest upon bone and mineral metabolism: Results from the PlanHab study. Bone, 91, pp. 130-138. Elsevier. DOI: 10.1016/j.bone.2016.07.013 ISSN 8756-3282

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Abstract

Abstract Bone losses are common as a consequence of unloading and also in patients with chronic obstructive pulmonary disease (COPD). Although hypoxia has been implicated as an important factor to drive bone loss, its interaction with unloading remains unresolved. The objective therefore was to assess whether human bone loss caused by unloading could be aggravated by chronic hypoxia. In a cross-over designed study, 14 healthy young men underwent 21-day interventions of bed rest in normoxia (NBR), bed rest in hypoxia (HBR), and hypoxic ambulatory confinement (HAmb). Hypoxic conditions were equivalent to 4000m altitude. Bone metabolism (NTX, P1NP, sclerostin, DKK1) and phospho-calcic homeostasis (calcium and phosphate serum levels and urinary excretion, PTH) were assessed from regular blood samples and 24-hour urine collections, and tibia and femur bone mineral content was assessed by peripheral quantitative computed tomography (pQCT). Urinary NTX excretion increased (P<0.001) to a similar extent in NBR and HBR (P=0.69) and P1NP serum levels decreased (P=0.0035) with likewise no difference between NBR and HBR (P=0.88). Serum total calcium was increased during bed rest by 0.059 (day D05, SE 0.05mM) to 0.091mM (day D21, P<0.001), with no additional effect by hypoxia during bed rest (P=0.199). HAmb led, at least temporally, to increased total serum calcium, to reduced serum phosphate, and to reduced phosphate and calcium excretion. In conclusion, hypoxia did not aggravate bed rest-induced bone resorption, but led to changes in phospho-calcic homeostasis likely caused by hyperventilation. Whether hyperventilation could have mitigated the effects of hypoxia in this study remains to be established.

Item URL in elib:https://elib.dlr.de/107463/
Document Type:Article
Title:On the combined effects of normobaric hypoxia and bed rest upon bone and mineral metabolism: Results from the PlanHab study
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Rittweger, J.Institute of Aerospace Medicine, Deutsches Zentrum für Luft- und Raumfahrt, DLR e.V., Cologne, Germany and Medical Faculty, University of Cologne, Cologne, Germany; joern.rittweger (at) dlr.deUNSPECIFIED
Debevec, T.Department of Automation, Biocybernetics and Robotics, Jozef Stefan Institute, Ljubljana, SloveniaUNSPECIFIED
Frings-Meuthen, P.German Aerospace Center (DLR), Institute of Aerospace Medicine, Space Physiology, Cologne, GermanyUNSPECIFIED
Lau, P.German Aerospace Center (DLR), Institute of Aerospace Medicine, Space Physiology, Cologne, GermanyUNSPECIFIED
Mittag, U.German Aerospace Center (DLR), Institute of Aerospace Medicine, Division of Space Physiology, Cologne, GermanyUNSPECIFIED
Ganse, B.Division Space Physiology, Institute of Aerospace Medicine, German Aerospace Center, Cologne, bergita.ganse (at) dlr.deUNSPECIFIED
Ferstl, P.G.Medizinische Klinik I, University of Frankfurt, Frankfurt, GermanyUNSPECIFIED
Simpson, E.J.MRC/Arthritis UK Centre for Musculoskeletal Aging Research, University of Nottingham Medical SchoolUNSPECIFIED
Macdonald, I.A.MRC/Arthritis UK Centre for Musculoskeletal Aging Research, University of Nottingham Medical SchoolUNSPECIFIED
Eiken, ODepartment of Environmental Physiology, Swedish Aerospace Physiology Centre, Royal Institute of Technology, Stockholm, SwedenUNSPECIFIED
Mekjavic, I.Jozef Stefan InstituteUNSPECIFIED
Date:19 October 2016
Journal or Publication Title:Bone
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:91
DOI :10.1016/j.bone.2016.07.013
Page Range:pp. 130-138
Editors:
EditorsEmail
Khosla, SundeepMayo Clinic, Rochester, MN, USA
Publisher:Elsevier
ISSN:8756-3282
Status:Published
Keywords:DKK1; Human physiology; Immobilization; Respiration; Sclerostin
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Integrative Studien (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Space Physiology
Deposited By: Becker, Christine
Deposited On:11 Jan 2017 10:03
Last Modified:11 Jan 2017 10:03

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