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Greater loss in muscle mass and function but smaller metabolic alterations in older compared with younger men following 2 wk of bed rest and recovery

Pisot, R. and Marusic, U and Biolo, G. and Mazzuco, S and Lazzer, S and Grassi, B. and Reggiani, C and Toniolo, L and di Prampero, P. and Pessaro, A and Narici, M.V. and Mohammed, S and Rittweger, J. and Gasparini, M and Gabrielcic Blenkus, M and Simunic, B (2016) Greater loss in muscle mass and function but smaller metabolic alterations in older compared with younger men following 2 wk of bed rest and recovery. Journal of Applied Physiology, 120 (8), pp. 922-929. American Physiological Society. DOI: 10.1152/japplphysiol.00858.2015 ISSN 8750-7587

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Abstract

This investigation aimed to compare the response of young and older adult men to bed rest (BR) and subsequent rehabilitation (R). Sixteen older (OM, age 55-65 yr) and seven young (YM, age 18-30 yr) men were exposed to a 14-day period of BR followed by 14 days of R. Quadriceps muscle volume (QVOL), force (QF), and explosive power (QP) of leg extensors; single-fiber isometric force (Fo); peak aerobic power (V̇o2peak); gait stride length; and three metabolic parameters, Matsuda index of insulin sensitivity, postprandial lipid curve, and homocysteine plasma level, were measured before and after BR and after R. Following BR, QVOL was smaller in OM (-8.3%) than in YM (-5.7%,P= 0.031); QF (-13.2%,P= 0.001), QP (-12.3%,P= 0.001), and gait stride length (-9.9%,P= 0.002) were smaller only in OM. Fo was significantly smaller in both YM (-32.0%) and OM (-16.4%) without significant differences between groups. V̇o2peakdecreased more in OM (-15.3%) than in YM (-7.6%,P< 0.001). Instead, the Matsuda index fell to a greater extent in YM than in OM (-46.0% vs. -19.8%, respectively,P= 0.003), whereas increases in postprandial lipid curve (+47.2%,P= 0.013) and homocysteine concentration (+26.3%,P= 0.027) were observed only in YM. Importantly, after R, the recovery of several parameters, among them QVOL, QP, and V̇o2peak, was not complete in OM, whereas Fo did not recover in either age group. The results show that the effect of inactivity on muscle mass and function is greater in OM, whereas metabolic alterations are greater in YM. Furthermore, these findings show that the recovery of preinactivity conditions is slower in OM.

Item URL in elib:https://elib.dlr.de/107359/
Document Type:Article
Title:Greater loss in muscle mass and function but smaller metabolic alterations in older compared with younger men following 2 wk of bed rest and recovery
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Pisot, R.University of Primorska, SloveniaUNSPECIFIED
Marusic, UUniversity of Trieste, ItalyUNSPECIFIED
Biolo, G.University of Trieste, ItalyUNSPECIFIED
Mazzuco, SUniversity of Trieste, ItalyUNSPECIFIED
Lazzer, SUniversity of Udine, ItalyUNSPECIFIED
Grassi, B.University of Udine, ItalyUNSPECIFIED
Reggiani, CUniversity of Padua, ItalyUNSPECIFIED
Toniolo, LUniversity of Padua, ItalyUNSPECIFIED
di Prampero, P.University of Udine, ItalyUNSPECIFIED
Pessaro, AUniversity of Ferrara, ItalyUNSPECIFIED
Narici, M.V.University of Nottingham, Nottingham, UKUNSPECIFIED
Mohammed, SUniversity of Nottingham, Derby Royal Hospital, United KingdomUNSPECIFIED
Rittweger, J.Institute of Aerospace Medicine, Deutsches Zentrum für Luft- und Raumfahrt, DLR e.V., Cologne, Germany and Medical Faculty, University of Cologne, Cologne, Germany; joern.rittweger (at) dlr.deUNSPECIFIED
Gasparini, MGeneral Hospital Izola, SloveniaUNSPECIFIED
Gabrielcic Blenkus, MNational Institute of Public Health of the Republic of Slovenia, Ljubljana, SloveniaUNSPECIFIED
Simunic, BUniversity of Primorska, SloveniaUNSPECIFIED
Date:15 April 2016
Journal or Publication Title:Journal of Applied Physiology
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:120
DOI :10.1152/japplphysiol.00858.2015
Page Range:pp. 922-929
Editors:
EditorsEmail
Wagner, Peter D.University of California, San Diego in La Jolla
Bates, Jason H. T.University of Vermont, Burlington
Publisher:American Physiological Society
ISSN:8750-7587
Status:Published
Keywords:aging; functional decline; prolonged physical inactivity; reconditioning
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Integrative Studien (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Space Physiology
Deposited By: Becker, Christine
Deposited On:09 Nov 2016 10:38
Last Modified:06 Sep 2019 15:27

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