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Serum sclerostin and DKK1 in relation to exercise against bone loss in experimental bed rest

Belavy, Daniel and Baecker, Natalie and Armbrecht, Gabriele and Beller, Gise and Buehlmeier, Judith and Frings-Meuthen, Petra and Rittweger, Jörn and Roth, H.J. and Heer, Martina and Felsenberg, Dieter (2016) Serum sclerostin and DKK1 in relation to exercise against bone loss in experimental bed rest. Journal of Bone and Mineral Metabolism, 34 (3), pp. 354-365. Springer. doi: 10.1007/s00774-015-0681-3. ISSN 0914-8779.

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The impact of effective exercise against bone loss during experimental bed rest appears to be associated with increases in bone formation rather than reductions of bone resorption. Sclerostin and dickkopf-1 are important inhibitors of osteoblast activity. We hypothesized that exercise in bed rest would prevent increases in sclerostin and dickkopf-1. Twenty-four male subjects performed resistive vibration exercise (RVE; n = 7), resistive exercise only (RE; n = 8), or no exercise (control n = 9) during 60 days of bed rest (2nd Berlin BedRest Study). We measured serum levels of BAP, CTX-I, iPTH, calcium, sclerostin, and dickkopf-1 at 16 time-points during and up to 1 year after bed rest. In inactive control, after an initial increase in both BAP and CTX-I, sclerostin increased. BAP then returned to baseline levels, and CTX-I continued to increase. In RVE and RE, BAP increased more than control in bed rest (p ≤ 0.029). Increases of CTX-I in RE and RVE did not differ significantly to inactive control. RE may have attenuated increases in sclerostin and dickkopf-1, but this was not statistically significant. In RVE there was no evidence for any impact on sclerostin and dickkopf-1 changes. Long-term recovery of bone was also measured and 6-24 months after bed rest, and proximal femur bone mineral content was still greater in RVE than control (p = 0.01). The results, while showing that exercise against bone loss in experimental bed rest results in greater bone formation, could not provide evidence that exercise impeded the rise in serum sclerostin and dickkopf-1 levels.

Item URL in elib:https://elib.dlr.de/107358/
Document Type:Article
Title:Serum sclerostin and DKK1 in relation to exercise against bone loss in experimental bed rest
AuthorsInstitution or Email of AuthorsAuthor's ORCID iD
Belavy, DanielCharite - University Medicine BerlinUNSPECIFIED
Armbrecht, GabrieleCharité Campus Benjamin FranklinUNSPECIFIED
Beller, GiseCharité Campus Benjamin FranklinUNSPECIFIED
Buehlmeier, JudithGerman Aerospace Center (DLR), Institute of Aerospace MedicineUNSPECIFIED
Frings-Meuthen, PetraGerman Aerospace Center (DLR), Institute of Aerospace Medicine, Space Physiology, Cologne, GermanyUNSPECIFIED
Rittweger, JörnInstitute of Aerospace Medicine, Deutsches Zentrum für Luft- und Raumfahrt, DLR e.V., Cologne, Germany and Medical Faculty, University of Cologne, Cologne, Germany; joern.rittweger (at) dlr.deUNSPECIFIED
Roth, H.J.Labor LimbachUNSPECIFIED
Heer, MartinaMartina.Heer (at) profil.comUNSPECIFIED
Felsenberg, DieterCharité Campus Benjamin FranklinUNSPECIFIED
Date:May 2016
Journal or Publication Title:Journal of Bone and Mineral Metabolism
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In ISI Web of Science:Yes
DOI :10.1007/s00774-015-0681-3
Page Range:pp. 354-365
EditorsEmailEditor's ORCID iD
Keywords:Bone mineral density; Immobilisation; Spaceflight; Training; pQCT
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Research under Space Conditions
DLR - Research theme (Project):R - Vorhaben Integrative Studien (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Space Physiology
Deposited By: Becker, Christine
Deposited On:09 Nov 2016 10:31
Last Modified:08 Mar 2018 18:37

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