Marshall-Goebel, Karina and Ambarku, Khalid and Eklund, Anders and Malm, Jan and Mulder, Edwin and Gerlach, Darius and Bershad, Eric and Rittweger, Jörn (2016) Effects of short-term exposure to head down tilt on cerebral hemodynamics: A prospective evaluation of a space-flight analog using phase contrast MRI. Journal of Applied Physiology (120), pp. 1466-1473. American Physiological Society. doi: 10.1152/japplphysiol.00841.2015. ISSN 8750-7587.
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Official URL: http://www.jappl.org
Abstract
Alterations in cerebral hemodynamics in microgravity are hypothesized to occur during spaceflight and could be linked to the Visual Impairment and Intracranial Pressure syndrome. Head-down tilt (HDT) is frequently used as a ground-based analog to simulate cephalad fluid shifts in microgravity; however, its effects on cerebral hemodynamics have not been well studied with MRI techniques. Here, we evaluate the effects of 1) various HDT angles on cerebral arterial and venous hemodynamics; and 2) exposure to 1% CO2 during an intermediate HDT angle (-12°) as an additional space-related environmental factor. Blood flow, cross-sectional area (CSA), and blood flow velocity were measured with phase-contrast MRI in the internal jugular veins, as well as the vertebral and internal carotid arteries. Nine healthy male subjects were measured at baseline (supine, 0°) and after 4.5 h of HDT at -6°, -12° (with and without 1% CO2), and -18°. We found a decrease in total arterial blood flow from baseline during all angles of HDT. On the venous side, CSA increased with HDT, and outflow decreased during -12° HDT (P = 0.039). Moreover, the addition of 1% CO2 to -12° HDT caused an increase in total arterial blood flow (P = 0.016) and jugular venous outflow (P < 0.001) compared with -12° HDT with ambient atmosphere. Overall, the results indicate decreased cerebral blood flow during HDT, which may have implications for microgravity-induced cerebral hemodynamic changes.
Item URL in elib: | https://elib.dlr.de/105085/ | |||||||||||||||||||||||||||
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Document Type: | Article | |||||||||||||||||||||||||||
Title: | Effects of short-term exposure to head down tilt on cerebral hemodynamics: A prospective evaluation of a space-flight analog using phase contrast MRI | |||||||||||||||||||||||||||
Authors: |
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Date: | 2016 | |||||||||||||||||||||||||||
Journal or Publication Title: | Journal of Applied Physiology | |||||||||||||||||||||||||||
Refereed publication: | Yes | |||||||||||||||||||||||||||
Open Access: | No | |||||||||||||||||||||||||||
Gold Open Access: | No | |||||||||||||||||||||||||||
In SCOPUS: | Yes | |||||||||||||||||||||||||||
In ISI Web of Science: | Yes | |||||||||||||||||||||||||||
DOI : | 10.1152/japplphysiol.00841.2015 | |||||||||||||||||||||||||||
Page Range: | pp. 1466-1473 | |||||||||||||||||||||||||||
Publisher: | American Physiological Society | |||||||||||||||||||||||||||
ISSN: | 8750-7587 | |||||||||||||||||||||||||||
Status: | Published | |||||||||||||||||||||||||||
Keywords: | visual impairment and intracranial pressure; microgravity; cerebral blood flow; head-down tilt; MRI | |||||||||||||||||||||||||||
HGF - Research field: | Aeronautics, Space and Transport | |||||||||||||||||||||||||||
HGF - Program: | Space | |||||||||||||||||||||||||||
HGF - Program Themes: | Research under Space Conditions | |||||||||||||||||||||||||||
DLR - Research area: | Raumfahrt | |||||||||||||||||||||||||||
DLR - Program: | R FR - Research under Space Conditions | |||||||||||||||||||||||||||
DLR - Research theme (Project): | R - Vorhaben Integrative Studien (old) | |||||||||||||||||||||||||||
Location: | Köln-Porz | |||||||||||||||||||||||||||
Institutes and Institutions: | Institute of Aerospace Medicine > Space Physiology | |||||||||||||||||||||||||||
Deposited By: | Becker, Christine | |||||||||||||||||||||||||||
Deposited On: | 06 Jul 2016 12:30 | |||||||||||||||||||||||||||
Last Modified: | 06 Sep 2019 15:27 |
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