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Effects of short-term exposure to head down tilt on cerebral hemodynamics: A prospective evaluation of a space-flight analog using phase contrast MRI

Marshall-Goebel, Karina and Ambarku, Khalid and Eklund, Anders and Malm, Jan and Mulder, Edwin and Gerlach, Darius and Bershad, Eric and Rittweger, Jörn (2016) Effects of short-term exposure to head down tilt on cerebral hemodynamics: A prospective evaluation of a space-flight analog using phase contrast MRI. Journal of Applied Physiology (120), pp. 1466-1473. American Physiological Society. DOI: 10.1152/japplphysiol.00841.2015 ISSN 8750-7587

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Official URL: http://www.jappl.org

Abstract

Alterations in cerebral hemodynamics in microgravity are hypothesized to occur during spaceflight and could be linked to the Visual Impairment and Intracranial Pressure syndrome. Head-down tilt (HDT) is frequently used as a ground-based analog to simulate cephalad fluid shifts in microgravity; however, its effects on cerebral hemodynamics have not been well studied with MRI techniques. Here, we evaluate the effects of 1) various HDT angles on cerebral arterial and venous hemodynamics; and 2) exposure to 1% CO2 during an intermediate HDT angle (-12°) as an additional space-related environmental factor. Blood flow, cross-sectional area (CSA), and blood flow velocity were measured with phase-contrast MRI in the internal jugular veins, as well as the vertebral and internal carotid arteries. Nine healthy male subjects were measured at baseline (supine, 0°) and after 4.5 h of HDT at -6°, -12° (with and without 1% CO2), and -18°. We found a decrease in total arterial blood flow from baseline during all angles of HDT. On the venous side, CSA increased with HDT, and outflow decreased during -12° HDT (P = 0.039). Moreover, the addition of 1% CO2 to -12° HDT caused an increase in total arterial blood flow (P = 0.016) and jugular venous outflow (P < 0.001) compared with -12° HDT with ambient atmosphere. Overall, the results indicate decreased cerebral blood flow during HDT, which may have implications for microgravity-induced cerebral hemodynamic changes.

Item URL in elib:https://elib.dlr.de/105085/
Document Type:Article
Title:Effects of short-term exposure to head down tilt on cerebral hemodynamics: A prospective evaluation of a space-flight analog using phase contrast MRI
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Marshall-Goebel, KarinaInstitute of Aerospace Medicine, German Aerospace Center (DLR)UNSPECIFIED
Ambarku, KhalidDepartment of Radiation Sciences, Umeå University, Umeå, Sweden;UNSPECIFIED
Eklund, AndersDepartment of Radiation Sciences, Umeå University, Umeå, SwedenUNSPECIFIED
Malm, JanDepartment of Pharmacology and Clinical Neuroscience, UmeåUNSPECIFIED
Mulder, EdwinGerman Aerospace Center (DLR), Institute of Aerospace Medicine, Space Physiology, Cologne, GermanyUNSPECIFIED
Gerlach, DariusDarius.Gerlach (at) dlr.dehttps://orcid.org/0000-0001-7044-6065
Bershad, EricDepartment of Neurology, Baylor College of Medicine, Houston, TexasUNSPECIFIED
Rittweger, JörnInstitute of Aerospace Medicine, Deutsches Zentrum für Luft- und Raumfahrt, DLR e.V., Cologne, Germany and Medical Faculty, University of Cologne, Cologne, Germany; joern.rittweger (at) dlr.deUNSPECIFIED
Date:2016
Journal or Publication Title:Journal of Applied Physiology
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In SCOPUS:Yes
In ISI Web of Science:Yes
DOI :10.1152/japplphysiol.00841.2015
Page Range:pp. 1466-1473
Publisher:American Physiological Society
ISSN:8750-7587
Status:Published
Keywords:visual impairment and intracranial pressure; microgravity; cerebral blood flow; head-down tilt; MRI
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Integrative Studien (old)
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Space Physiology
Deposited By: Becker, Christine
Deposited On:06 Jul 2016 12:30
Last Modified:06 Sep 2019 15:27

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