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High-energy proton imaging for biomedical applications

Prall, M. and Durante, M. and Berger, T. and Przybyla, B. and Graeff, C. and Lang, P. M. and LaTessa, C. and Shestov, L. and Simoniello, P. and Danly, C. and Mariam, F. and Merrill, F. and Nedrow, P. and Wilde, C. and Varentsov, D. (2016) High-energy proton imaging for biomedical applications. Scientific Reports, 6 (27651). Nature Publishing Group. DOI: 10.1038/srep27651 ISSN 2045-2322

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Official URL: http://dx.doi.org/10.1038/srep27651

Abstract

The charged particle community is looking for techniques exploiting proton interactions instead of X-ray absorption for creating images of human tissue. Due to multiple Coulomb scattering inside the measured object it has shown to be highly non-trivial to achieve sufficient spatial resolution. We present imaging of biological tissue with a proton microscope. This device relies on magnetic optics, distinguishing it from most published proton imaging methods. For these methods reducing the data acquisition time to a clinically acceptable level has turned out to be challenging. In a proton microscope, data acquisition and processing are much simpler. This device even allows imaging in real time. The primary medical application will be image guidance in proton radiosurgery. Proton images demonstrating the potential for this application are presented. Tomographic reconstructions are included to raise awareness of the possibility of high-resolution proton tomography using magnetooptics.

Item URL in elib:https://elib.dlr.de/104668/
Document Type:Article
Title:High-energy proton imaging for biomedical applications
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Prall, M.GSI Helmholtzzentrum für Schwerionenforschung GmbH, Planckstraße 1, 64291 Darmstadt, Germany.UNSPECIFIED
Durante, M.GSI Helmholtzzentrum für Schwerionenforschung GmbH, Planckstraße 1, 64291 Darmstadt, Germany and Technische Universität Darmstadt, Schlossgartenstraße 9, 64289 Darmstadt, Germany.UNSPECIFIED
Berger, T.Deutsches Zentrum für Luft- und Raumfahrt (DLR), Lindner Höhe, 51147 Cologne, Germany.UNSPECIFIED
Przybyla, B.Deutsches Zentrum für Luft- und Raumfahrt (DLR), Lindner Höhe, 51147 Cologne, Germany.UNSPECIFIED
Graeff, C.GSI Helmholtzzentrum für Schwerionenforschung GmbH, Planckstraße 1, 64291 Darmstadt, Germany.UNSPECIFIED
Lang, P. M.GSI Helmholtzzentrum für Schwerionenforschung GmbH, Planckstraße 1, 64291 Darmstadt, Germany and Technische Universität Darmstadt, Schlossgartenstraße 9, 64289 Darmstadt, Germany.UNSPECIFIED
LaTessa, C.Brookhaven National Laboratory, P. O. Box 5000, Upton, NY 11973-5000, USA.UNSPECIFIED
Shestov, L.GSI Helmholtzzentrum für Schwerionenforschung GmbH, Planckstraße 1, 64291 Darmstadt, Germany and Technische Universität Darmstadt, Schlossgartenstraße 9, 64289 Darmstadt, Germany and Frankfurt Institute for Advanced Studies (FIAS), Frankfurt, Germany.UNSPECIFIED
Simoniello, P.GSI Helmholtzzentrum für Schwerionenforschung GmbH, Planckstraße 1, 64291 Darmstadt, Germany.UNSPECIFIED
Danly, C.Los Alamos National Laboratory, Los Alamos, NM 87545, USA.UNSPECIFIED
Mariam, F.Los Alamos National Laboratory, Los Alamos, NM 87545, USA.UNSPECIFIED
Merrill, F.Los Alamos National Laboratory, Los Alamos, NM 87545, USA.UNSPECIFIED
Nedrow, P.Los Alamos National Laboratory, Los Alamos, NM 87545, USA.UNSPECIFIED
Wilde, C.Los Alamos National Laboratory, Los Alamos, NM 87545, USA.UNSPECIFIED
Varentsov, D.GSI Helmholtzzentrum für Schwerionenforschung GmbH, Planckstraße 1, 64291 Darmstadt, Germany.UNSPECIFIED
Date:2016
Journal or Publication Title:Scientific Reports
Refereed publication:Yes
Open Access:Yes
Gold Open Access:Yes
In SCOPUS:Yes
In ISI Web of Science:Yes
Volume:6
DOI :10.1038/srep27651
Publisher:Nature Publishing Group
ISSN:2045-2322
Status:Published
Keywords:high-energy proton imaging, proton microscope, proton tomography of biological and medical samples, Matroshka phantom
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Strahlenbiologie
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Radiation Biology
Deposited By: Kopp, Kerstin
Deposited On:15 Jun 2016 10:08
Last Modified:08 Mar 2018 18:36

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