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Ground-Based Facilities at the DLR Institute of Aerospace Medicine for Studies in Gravitational Biology

Brungs, Sonja and Shinde, Vaibhav and Krause, Lars and Frett, Timo and Hauslage, Jens and Hescheler, Jürgen and Sachinidis, Apapios and Hemmersbach, Ruth (2015) Ground-Based Facilities at the DLR Institute of Aerospace Medicine for Studies in Gravitational Biology. 31st Annual Meeting of the American Society for Gravitational and Space Research (ASGSR) 2015, 10. -14. Nov. 2015, Alexandria, Virginia, USA.

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Official URL: https://www.asgsr.org/

Abstract

Our group provides experimental platforms to simulate the conditions of microgravity on ground. Clinostats, a Random Positioning Machine and a Rotating-Wall Vessel have been adapted to allow investigations employing a variety of different model organisms like larval fish, plants, algae, unicellular organisms as well as adherent or suspended cells in culture. Different types of clinostats have been developed which meet a broad variety of experimental applications such as parallel operation of up to ten sample containments in a defined environment, their fixation during rotation, direct microscopical observation of samples and bioluminescence kinetic measurements within cell cultures. Various centrifuge devices complete our experimental scenario, enabling hypergravity studies from cells to humans. Part of our ground-based data has already been validated in the course of experiments carried out under real microgravity. Currently, our studies focus on the effects of simulated microgravity and real microgravity on macrophage signalling as well as stem cell development and differentiation (embryonic stem cells). Our results support the necessity of a ground-based facility program, which - at low costs in comparison to space flight - give scientists the opportunity to intensively prepare their space experiments and get sufficient and statistically reliable and relevant data. Furthermore, our ground-based facilities build an excellent baseline in preparation of ISS experiments, e.g. for BIOLAB.

Item URL in elib:https://elib.dlr.de/102953/
Document Type:Conference or Workshop Item (Speech)
Title:Ground-Based Facilities at the DLR Institute of Aerospace Medicine for Studies in Gravitational Biology
Authors:
AuthorsInstitution or Email of AuthorsAuthors ORCID iD
Brungs, SonjaGerman Aerospace Centre (DLR), Institute of Aerospace Medicine, Gravitational Biology, Cologne, GermanyUNSPECIFIED
Shinde, VaibhavUniversity of Cologne, Institute of Neurophysiology and Center for Molecular Medicine Cologne (CMMC), Cologne, GermanyUNSPECIFIED
Krause, LarsGerman Aerospace Centre (DLR), Institute of Aerospace Medicine, Gravitational Biology, Cologne, GermanyUNSPECIFIED
Frett, TimoGerman Aerospace Center (DLR), Institute of Aerospace Medicine, Gravitational Biology, Cologne, GermanyUNSPECIFIED
Hauslage, JensGerman Aerospace Centre (DLR), Institute of Aerospace Medicine, Gravitational Biology, Cologne, GermanyUNSPECIFIED
Hescheler, JürgenUniversity of Cologne, Institute of Neurophysiology and Center for Molecular Medicine Cologne (CMMC), Cologne, GermanyUNSPECIFIED
Sachinidis, ApapiosUniversity of Cologne, Institute of Neurophysiology and Center for Molecular Medicine Cologne (CMMC), Cologne, GermanyUNSPECIFIED
Hemmersbach, RuthGerman Aerospace Center (DLR), Institute of Aerospace Medicine, Gravitational Biology, Cologne, GermanyUNSPECIFIED
Date:12 November 2015
Refereed publication:Yes
Open Access:No
Gold Open Access:No
In SCOPUS:No
In ISI Web of Science:No
Status:Published
Keywords:Microgravity, Hypergravity, Clinostat, Centrifuge, Random Positioning Machine, Rotating Wall Vessel
Event Title:31st Annual Meeting of the American Society for Gravitational and Space Research (ASGSR) 2015
Event Location:Alexandria, Virginia, USA
Event Type:international Conference
Event Dates:10. -14. Nov. 2015
Organizer:American Society for Gravitational and Space Research (ASGSR)
HGF - Research field:Aeronautics, Space and Transport
HGF - Program:Space
HGF - Program Themes:Research under Space Conditions
DLR - Research area:Raumfahrt
DLR - Program:R FR - Forschung unter Weltraumbedingungen
DLR - Research theme (Project):R - Vorhaben Biowissenschaftliche Nutzerunterstützung
Location: Köln-Porz
Institutes and Institutions:Institute of Aerospace Medicine > Biomedical Research
Deposited By: Duwe, Helmut
Deposited On:11 Feb 2016 08:57
Last Modified:10 May 2016 23:44

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